K11754


Help to interpret the results

Three outputs have been generated:
General: this result contains the description and frequency of the selected Kegg Orthologs K11754, of which KO pathways and KO modules it is part. Additionally, its occurence in the database is reported.
Proteins list: list of occurences of the Kegg Orthologs within the database. 7 occurences are identified. The table reports the orthogroup, the organism in which each occurrence has been found, and the locus tag enriched by start and stop position, strand, gene name and product.
Clicking on the Ortohgroup name or locus you will be redirected to further info.
Profiles: Phylogenetic tree annotated with
- the presence of the Kegg Ortholog(s) of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Kegg Orthologs has been clustered.
In red the Kegg Orthologs with positive hit(s) in the corresponding genome.
In green the discrepencies between orthogroup clustering and Kegg Orthologs prediction. Green homologs (same orthogroup) are not positive hit(s) for the considered Kegg Orthologs.

Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Kegg Orthologs prediction.

Description

External link K11754
KO K11754
Description dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17]

KO part of 3 pathways

Folate biosynthesis
Metabolic pathways
Biosynthesis of cofactors

KO part of 2 modules

M00126 Cofactor and vitamin metabolism Tetrahydrofolate biosynthesis, GTP => THF
M00841 Cofactor and vitamin metabolism Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF

Occurence in the database

K11754 is associated with 7 different proteins (see tab "Protein list" and "Profile")
The 7 proteins are classified into 1 different orthogroup(s)
# Orthogroup Locus Start Stop S. Gene Product Organism
0 group_1913 PMI_RS08760 1915680 1916978 -1 folC bifunctional tetrahydrofolate synthase/dihydrofolate synthase Proteus mirabilis HI4320
1 group_1913 FBDBKF_14250 49351 50703 -1 folC bifunctional tetrahydrofolate synthase/dihydrofolate synthase Morganella morganii S1
2 group_1913 EHELCC_08030 66282 67634 1 folC bifunctional tetrahydrofolate synthase/dihydrofolate synthase Morganella morganii S2
3 group_1913 NLDBIP_08355 66282 67634 1 folC bifunctional tetrahydrofolate synthase/dihydrofolate synthase Morganella morganii S4
4 group_1913 LHKJJB_05910 189525 190877 -1 folC bifunctional tetrahydrofolate synthase/dihydrofolate synthase Morganella morganii S3
5 group_1913 HKOGLL_05005 50873 52225 1 folC bifunctional tetrahydrofolate synthase/dihydrofolate synthase Morganella morganii S5
6 group_1913 F4V73_RS02660 559884 561185 1 folC bifunctional tetrahydrofolate synthase/dihydrofolate synthase Morganella psychrotolerans