Homologs in group_1913

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6 homologs were identified in 6 genomes with OrthoFinder.
The following table displays the locus tag of each homolog, the organism to which it belongs, the gene name and product.

Locus tag Identity Source Gene Product
FBDBKF_14250 FBDBKF_14250 100.0 Morganella morganii S1 folC bifunctional tetrahydrofolate synthase/dihydrofolate synthase
EHELCC_08030 EHELCC_08030 100.0 Morganella morganii S2 folC bifunctional tetrahydrofolate synthase/dihydrofolate synthase
NLDBIP_08355 NLDBIP_08355 100.0 Morganella morganii S4 folC bifunctional tetrahydrofolate synthase/dihydrofolate synthase
LHKJJB_05910 LHKJJB_05910 100.0 Morganella morganii S3 folC bifunctional tetrahydrofolate synthase/dihydrofolate synthase
F4V73_RS02660 F4V73_RS02660 91.2 Morganella psychrotolerans folC bifunctional tetrahydrofolate synthase/dihydrofolate synthase
PMI_RS08760 PMI_RS08760 64.4 Proteus mirabilis HI4320 folC bifunctional tetrahydrofolate synthase/dihydrofolate synthase

Distribution of the homologs in the orthogroup group_1913

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Number of homologs in each genome (first column) and amino-acid identity of the closest homolog (second column).

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Phylogeny of the RefSeq best hits of group_1913

Swissprot accession Eval Score ID (%) N gaps Alignment length Annot score Gene Description Organism
P08192 1.5e-162 468 57 2 428 1 folC Dihydrofolate synthase/folylpolyglutamate synthase Escherichia coli (strain K12)
P43775 6.85e-124 370 46 5 437 3 folC Dihydrofolate synthase/folylpolyglutamate synthase Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Q8K9X3 3.03e-104 319 40 5 410 3 folC Dihydrofolate synthase/folylpolyglutamate synthase Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
P57265 1.16e-98 304 41 6 414 3 folC Dihydrofolate synthase/folylpolyglutamate synthase Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)
Q89AT2 3.14e-93 291 38 4 418 3 folC Dihydrofolate synthase/folylpolyglutamate synthase Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Q9HS44 1.4e-44 169 33 12 408 3 folP Probable bifunctional folylpolyglutamate synthase/dihydropteroate synthase Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
P15925 5.09e-38 146 28 6 391 1 fpgS Folylpolyglutamate synthase Lacticaseibacillus casei
D4GW05 4.23e-35 142 31 11 427 3 folCP Probable bifunctional folylpolyglutamate synthase/dihydropteroate synthase Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)
Q05865 1.04e-34 137 27 10 408 3 folC Dihydrofolate synthase/folylpolyglutamate synthase Bacillus subtilis (strain 168)
A6H751 1.11e-32 134 31 16 384 2 FPGS Folylpolyglutamate synthase, mitochondrial Bos taurus
Q05932 3.76e-32 132 30 14 382 1 FPGS Folylpolyglutamate synthase, mitochondrial Homo sapiens
Q8W035 1.43e-31 129 35 11 290 1 FPGS3 Folylpolyglutamate synthase Arabidopsis thaliana
I6Y0R5 1.56e-31 129 30 8 365 1 folC Dihydrofolate synthase/folylpolyglutamate synthase Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Q924L9 2.52e-30 127 30 14 375 2 FPGS Folylpolyglutamate synthase, mitochondrial Cricetulus griseus
Q9UTD0 3.69e-30 124 26 10 424 3 fol3 Probable dihydrofolate synthetase Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q09509 9.65e-30 124 32 8 300 3 F25B5.6 Putative folylpolyglutamate synthase Caenorhabditis elegans
F4JYE9 1.7e-29 124 27 14 462 1 DHFS Dihydrofolate synthetase Arabidopsis thaliana
P48760 6e-29 122 29 14 375 1 Fpgs Folylpolyglutamate synthase, mitochondrial Mus musculus
Q12676 4.42e-28 118 26 16 442 1 FOL3 Dihydrofolate synthetase Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F4J2K2 3.62e-26 115 38 3 180 1 FPGS2 Folylpolyglutamate synthase Arabidopsis thaliana
F4K2A1 1.03e-25 113 29 10 341 1 FPGS1 Folylpolyglutamate synthase Arabidopsis thaliana
O74742 9.05e-25 110 31 10 276 2 met7 Probable folylpolyglutamate synthase Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q9Y893 1.46e-24 109 28 11 292 3 MET7 Folylpolyglutamate synthase Candida albicans
Q54CY5 2.34e-24 109 35 4 182 3 folC Putative folylpolyglutamate synthase Dictyostelium discoideum
E7NMM0 5.77e-19 92 27 11 309 3 MET7 Folylpolyglutamate synthase Saccharomyces cerevisiae (strain FostersO)
E7Q9C7 1.13e-18 92 33 6 192 3 MET7 Folylpolyglutamate synthase Saccharomyces cerevisiae (strain FostersB)
E7KIA3 1.13e-18 92 33 6 192 3 MET7 Folylpolyglutamate synthase Saccharomyces cerevisiae (strain AWRI796)
E7QKX4 1.17e-18 92 33 6 192 3 MET7 Folylpolyglutamate synthase Saccharomyces cerevisiae (strain Zymaflore VL3)
Q08645 1.17e-18 92 33 6 192 1 MET7 Folylpolyglutamate synthase Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E7KUJ4 1.17e-18 92 33 6 192 3 MET7 Folylpolyglutamate synthase Saccharomyces cerevisiae (strain Lalvin QA23)
C8ZGZ3 1.17e-18 92 33 6 192 3 MET7 Folylpolyglutamate synthase Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse)
A6ZP80 1.17e-18 92 33 6 192 3 MET7 Folylpolyglutamate synthase Saccharomyces cerevisiae (strain YJM789)
B3LJR0 1.17e-18 92 33 6 192 3 MET7 Folylpolyglutamate synthase Saccharomyces cerevisiae (strain RM11-1a)
B5VSC3 1.21e-18 92 33 6 192 3 MET7 Folylpolyglutamate synthase Saccharomyces cerevisiae (strain AWRI1631)
O13492 8.85e-17 86 32 6 183 1 met-6 Folylpolyglutamate synthase Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q72R81 0.000416 46 22 16 337 3 murE UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)
Q8F4J4 0.00043 46 22 16 337 3 murE UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)

  • Number of RefSeq hits:

General

Source Morganella morganii S5
Locus tag HKOGLL_05005
Feature type CDS
Gene folC
Product bifunctional tetrahydrofolate synthase/dihydrofolate synthase
Location 50873 - 52225 (strand: 1)
Length 1353 (nucleotides) / 450 (amino acids)

Contig

Accession ZDB_682
Length 259781 nucleotides
Topology linear
Plasmid False

Orthology

Orthogroup group_1913
Orthogroup size 7
N. genomes 7

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Genomic region

Domains

PF02875 Mur ligase, glutamate ligase domain
PF08245 Mur ligase middle domain

COG entry Annotation(s)

ID Function(s) descr. Function(s) cat. Description
COG0285 Coenzyme transport and metabolism (H) H Folylpolyglutamate synthase/Dihydropteroate synthase

Kegg Ortholog Annotation(s)

KO Description Pathways Modules
K11754 dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17] Folate biosynthesis
Metabolic pathways
Biosynthesis of cofactors		 Tetrahydrofolate biosynthesis, GTP => THF
Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF

Protein Sequence

MNLIPTYLLKQRLMSKNTMSDKRERPTAASSMMTWLSYLGDLHTQVIDMGLGRVGAVADIMNLRYPAPKVITVSGTNGKGTTCHTLESILLAAGLRVGVYSSPHLVNYTERVRIQGQNPPEADFCRVFADIDAQRGDITLTYFEAGTLAALQLFREANLDVVILEVGLGGRLDATNIVDSHITAITSIALDHTDWLGADREHIAREKAGIFRPHCVAVIGEPDAPYTIADVANKLETSLFCRADDWSYKEQGDHWTWQCEDETLDNLPLPNVPLANAATALAVIHNLRQVKDKTGRAITREAIDTGLRQAQLPGRFQIVSQQPLTVLDVAHNPHAAGYLVSKLAQLPRTEQSRVRAVIGMLGDKDIKGTLAVLGEQVTDWYVAPLTELRGAPAEQLAEHLTNPQQFADVESAWEQARRDASPEDIVVVCGSFHTVAHVMDVLAKEGTGGQ

Flanking regions ( +/- flanking 50bp)

GAACTATCAGTTCCCGCAGGAAGGTGAAATCATTGAAATCCTGACCGCGGATGAACCTGATTCCGACTTATCTTCTGAAACAGAGACTGATGTCAAAAAACACGATGTCTGATAAGCGAGAAAGACCGACAGCCGCGTCATCGATGATGACGTGGCTTTCTTATCTGGGTGATCTGCATACGCAGGTTATTGATATGGGACTGGGACGTGTCGGTGCGGTGGCGGATATCATGAATCTGCGCTATCCCGCCCCGAAAGTCATTACCGTTTCCGGAACCAACGGCAAAGGCACCACCTGCCATACACTCGAATCCATCCTGCTGGCCGCAGGGTTGCGGGTCGGCGTGTACAGTTCCCCGCATCTGGTGAATTACACCGAACGGGTGCGGATCCAGGGGCAAAACCCGCCGGAAGCGGATTTCTGCCGTGTCTTTGCTGATATTGACGCGCAGCGCGGCGATATCACACTGACCTATTTTGAAGCGGGCACTCTGGCAGCACTGCAGCTGTTCCGCGAAGCCAACCTTGATGTGGTGATTCTGGAAGTCGGCCTCGGCGGGCGTCTGGATGCCACCAATATCGTCGATTCTCATATCACGGCTATCACCAGTATCGCGCTGGATCACACCGACTGGCTCGGCGCTGACCGCGAGCATATCGCCCGCGAGAAAGCCGGAATTTTCCGCCCGCACTGTGTGGCGGTGATCGGTGAGCCGGATGCGCCTTATACCATCGCTGACGTGGCAAACAAGCTGGAAACCTCGCTGTTCTGCCGTGCCGATGACTGGTCTTACAAAGAGCAGGGTGACCACTGGACGTGGCAGTGTGAGGATGAAACCCTCGACAATCTGCCGCTGCCGAATGTGCCGCTGGCAAATGCCGCGACTGCCCTTGCAGTGATCCACAATCTGCGTCAGGTGAAAGACAAAACCGGCCGCGCCATCACCCGTGAGGCGATTGATACCGGGCTGCGTCAGGCACAACTGCCGGGCCGTTTTCAGATTGTCTCACAGCAACCGCTGACCGTGCTGGATGTGGCGCATAACCCGCATGCTGCCGGTTATCTGGTCTCAAAACTGGCACAGCTGCCGCGCACTGAGCAGAGCCGTGTCCGTGCCGTGATTGGTATGCTGGGCGACAAAGATATCAAAGGCACCCTGGCGGTGCTGGGTGAGCAGGTGACGGACTGGTATGTCGCGCCGCTGACCGAACTGCGCGGAGCCCCGGCCGAACAGCTGGCGGAGCATCTGACCAACCCGCAGCAGTTTGCCGATGTGGAAAGTGCCTGGGAACAGGCGCGCCGTGATGCCTCACCGGAGGATATCGTGGTGGTGTGCGGGTCATTCCACACAGTGGCTCATGTTATGGATGTTTTAGCGAAGGAAGGTACGGGTGGCCAGTAAATTTCAGAATCGCTTAGTCGGAACCATTATCCTGGTGGCGGTGGGTGTGA