K00287


Help to interpret the results

Three outputs have been generated:
General: this result contains the description and frequency of the selected Kegg Orthologs K00287, of which KO pathways and KO modules it is part. Additionally, its occurence in the database is reported.
Proteins list: list of occurences of the Kegg Orthologs within the database. 8 occurences are identified. The table reports the orthogroup, the organism in which each occurrence has been found, and the locus tag enriched by start and stop position, strand, gene name and product.
Clicking on the Ortohgroup name or locus you will be redirected to further info.
Profiles: Phylogenetic tree annotated with
- the presence of the Kegg Ortholog(s) of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Kegg Orthologs has been clustered.
In red the Kegg Orthologs with positive hit(s) in the corresponding genome.
In green the discrepencies between orthogroup clustering and Kegg Orthologs prediction. Green homologs (same orthogroup) are not positive hit(s) for the considered Kegg Orthologs.

Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Kegg Orthologs prediction.

Description

External link K00287
KO K00287
Description dihydrofolate reductase [EC:1.5.1.3]

KO part of 5 pathways

One carbon pool by folate
Folate biosynthesis
Metabolic pathways
Biosynthesis of cofactors
Antifolate resistance

KO part of 2 modules

M00126 Cofactor and vitamin metabolism Tetrahydrofolate biosynthesis, GTP => THF
M00840 Cofactor and vitamin metabolism Tetrahydrofolate biosynthesis, mediated by ribA and trpF, GTP => THF

Occurence in the database

K00287 is associated with 8 different proteins (see tab "Protein list" and "Profile")
The 8 proteins are classified into 1 different orthogroup(s)
# Orthogroup Locus Start Stop S. Gene Product Organism
0 group_283 PMI_RS11560 2549655 2550140 -1 folA type 3 dihydrofolate reductase Proteus mirabilis HI4320
1 group_283 FBDBKF_06280 88639 89133 -1 folA type 3 dihydrofolate reductase Morganella morganii S1
2 group_283 EHELCC_09325 89211 89705 -1 folA type 3 dihydrofolate reductase Morganella morganii S2
3 group_283 NLDBIP_09705 89211 89705 -1 folA type 3 dihydrofolate reductase Morganella morganii S4
4 group_283 LHKJJB_08050 127533 128027 1 folA type 3 dihydrofolate reductase Morganella morganii S3
5 group_283 HKOGLL_07600 127533 128027 1 folA type 3 dihydrofolate reductase Morganella morganii S5
6 group_283 F4V73_RS17885 19299 19784 -1 dihydrofolate reductase Morganella psychrotolerans
7 group_283 F4V73_RS15640 124958 125452 1 folA type 3 dihydrofolate reductase Morganella psychrotolerans