K00287


Help to interpret the results

Three outputs have been generated:
General: this tab contains the description, occurence in the database and other information related to the selected Kegg Ortholog K00287
Protein list: lists the 8 occurences of the Kegg Ortholog within the database. The table reports information on each occurence.
Profile: phylogenetic tree annotated with
- the presence of the Kegg Ortholog of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Kegg Ortholog has been clustered.
Orthogroups are shown in red if they are annotated with that particular Kegg Ortholog in a given genome , in green otherwise, i.e. if there is a discrepency between orthogroup clustering and Kegg Ortholog prediction.
Green homologs (same orthogroup) are not positive hit(s) for the considered Kegg Ortholog.
Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Kegg Ortholog prediction.

Description

External link K00287
KO K00287
Description dihydrofolate reductase [EC:1.5.1.3]

KO part of 6 pathways

One carbon pool by folate
Folate biosynthesis
Metabolic pathways
Biosynthesis of cofactors
Antifolate resistance
Folate transport and metabolism

KO part of 2 modules

M00126 Cofactor and vitamin metabolism Tetrahydrofolate biosynthesis, GTP => THF
M00840 Cofactor and vitamin metabolism Tetrahydrofolate biosynthesis, mediated by ribA and trpF, GTP => THF

Occurence in the database

K00287 is associated with 8 different proteins
The 8 proteins are classified into 1 different orthogroup(s)
Orthogroup Locus Start Stop S. Gene Product Organism
0 group_258 FBDBKF_06280 88639 89133 -1 folA type 3 dihydrofolate reductase Morganella morganii S1
1 group_258 EHELCC_09325 89211 89705 -1 folA type 3 dihydrofolate reductase Morganella morganii S2
2 group_258 NLDBIP_09705 89211 89705 -1 folA type 3 dihydrofolate reductase Morganella morganii S4
3 group_258 LHKJJB_08050 127533 128027 1 folA type 3 dihydrofolate reductase Morganella morganii S3
4 group_258 HKOGLL_07600 127533 128027 1 folA type 3 dihydrofolate reductase Morganella morganii S5
5 group_258 F4V73_RS15640 124958 125452 1 folA type 3 dihydrofolate reductase Morganella psychrotolerans
6 group_258 F4V73_RS17885 19299 19784 -1 dihydrofolate reductase Morganella psychrotolerans
7 group_258 PMI_RS11560 2549655 2550140 -1 folA type 3 dihydrofolate reductase Proteus mirabilis HI4320