Help to interpret the results
The page contains two contents:
General: this table lists the KO entries and their description specific to this pathway, and provides their frequencies in Proteus mirabilis HI4320 and in the whole dataset.
Profile + homologs: the distribution of the Kegg entries of One carbon pool by folate Kegg pathway is displayed here. Given a Kegg entry and a genome, a red box indicates that one or more loci have been annotated with, while a green box indicates that no locus/loci has(have) been annotated with it, but it/they is/are part of an Orthologous group in which other members have been annotated with that Kegg entry, so it is likely that this copy(ies) also performs this Kegg function.
Check the composition of the One carbon pool by folate pathway
| KO | Description | #in this genome | All occurrences |
|---|---|---|---|
| K00108 | choline dehydrogenase [EC:1.1.99.1] | 1 | 1 |
| K00130 | betaine-aldehyde dehydrogenase [EC:1.2.1.8] | 1 | 1 |
| K00281 | glycine cleavage system P protein (glycine dehydrogenase) [EC:1.4.4.2] | 1 | 7 |
| K00282 | glycine cleavage system P protein (glycine dehydrogenase) subunit 1 [EC:1.4.4.2] | 0 | 0 |
| K00283 | glycine cleavage system P protein (glycine dehydrogenase) subunit 2 [EC:1.4.4.2] | 0 | 0 |
| K00287 | dihydrofolate reductase [EC:1.5.1.3] | 1 | 8 |
| K00288 | methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3] | 0 | 0 |
| K00289 | formyltetrahydrofolate dehydrogenase [EC:1.5.1.6] | 0 | 0 |
| K00295 | methylenetetrahydrofolate dehydrogenase (NAD+) [EC:1.5.1.15] | 0 | 0 |
| K00297 | methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54] | 1 | 7 |
| K00300 | methylenetetrahydrofolate/methylenetetrahydromethanopterin dehydrogenase (NADP+) [EC:1.5.1.5 1.5.1.-] | 0 | 0 |
| K00309 | dimethylglycine oxidase [EC:1.5.3.10] | 0 | 0 |
| K00314 | sarcosine dehydrogenase [EC:1.5.8.3] | 0 | 0 |
| K00315 | dimethylglycine dehydrogenase [EC:1.5.8.4] | 0 | 0 |
| K00382 | dihydrolipoyl dehydrogenase [EC:1.8.1.4] | 1 | 7 |
| K00499 | choline monooxygenase [EC:1.14.15.7] | 0 | 0 |
| K00544 | betaine-homocysteine S-methyltransferase [EC:2.1.1.5] | 0 | 0 |
| K00547 | homocysteine S-methyltransferase [EC:2.1.1.10] | 0 | 0 |
| K00548 | 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13] | 1 | 7 |
| K00552 | glycine N-methyltransferase [EC:2.1.1.20] | 0 | 0 |
| K00560 | thymidylate synthase [EC:2.1.1.45] | 1 | 8 |
| K00600 | glycine hydroxymethyltransferase [EC:2.1.2.1] | 1 | 7 |
| K00601 | phosphoribosylglycinamide formyltransferase [EC:2.1.2.2] | 0 | 0 |
| K00602 | phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10] | 1 | 7 |
| K00603 | glutamate formiminotransferase / 5-formyltetrahydrofolate cyclo-ligase [EC:2.1.2.5 6.3.3.2] | 0 | 0 |
| K00605 | glycine cleavage system T protein (aminomethyltransferase) [EC:2.1.2.10] | 1 | 7 |
| K00789 | S-adenosylmethionine synthetase [EC:2.5.1.6] | 1 | 7 |
| K01251 | adenosylhomocysteinase [EC:3.13.2.1] | 0 | 6 |
| K01433 | formyltetrahydrofolate deformylase [EC:3.5.1.10] | 1 | 7 |
| K01491 | methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9] | 1 | 7 |
| K01492 | phosphoribosylglycinamide/phosphoribosylaminoimidazolecarboxamide formyltransferase [EC:2.1.2.2 2.1.2.3] | 0 | 0 |
| K01500 | methenyltetrahydrofolate cyclohydrolase [EC:3.5.4.9] | 0 | 0 |
| K01697 | cystathionine beta-synthase [EC:4.2.1.22] | 0 | 0 |
| K01746 | formiminotetrahydrofolate cyclodeaminase [EC:4.3.1.4] | 0 | 0 |
| K01758 | cystathionine gamma-lyase [EC:4.4.1.1] | 0 | 0 |
| K01934 | 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2] | 1 | 7 |
| K01938 | formate--tetrahydrofolate ligase [EC:6.3.4.3] | 1 | 1 |
| K02437 | glycine cleavage system H protein | 1 | 7 |
| K03465 | thymidylate synthase (FAD) [EC:2.1.1.148] | 0 | 0 |
| K10150 | cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase [EC:2.5.1.47 2.5.1.65 4.2.1.22] | 0 | 0 |
| K11175 | phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2] | 1 | 7 |
| K11440 | choline dehydrogenase [EC:1.1.1.1] | 0 | 0 |
| K11787 | phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.4.13 2.1.2.2 6.3.3.1] | 0 | 0 |
| K13402 | monofunctional C1-tetrahydrofolate synthase, mitochondrial [EC:6.3.4.3] | 0 | 0 |
| K13403 | methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.15 3.5.4.9] | 0 | 0 |
| K13938 | dihydromonapterin reductase / dihydrofolate reductase [EC:1.5.1.50 1.5.1.3] | 0 | 0 |
| K13990 | glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase [EC:2.1.2.5 4.3.1.4] | 0 | 0 |
| K13998 | dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45] | 0 | 0 |
| K14085 | aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3] | 0 | 0 |
| K17217 | cystathionine gamma-lyase / homocysteine desulfhydrase [EC:4.4.1.1 4.4.1.2] | 0 | 0 |
| K17755 | choline oxidase [EC:1.1.3.17] | 0 | 0 |
| K18589 | dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] | 0 | 5 |
| K18590 | dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] | 0 | 4 |
| K18591 | dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] | 0 | 0 |
| K19643 | dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] | 0 | 0 |
| K19644 | dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] | 0 | 0 |
| K19645 | dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] | 0 | 0 |
| K24042 | methionine synthase / methylenetetrahydrofolate reductase (NADH) [EC:2.1.1.13 1.5.1.54] | 0 | 0 |
| K25004 | methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.53] | 0 | 0 |
| K25007 | methylenetetrahydrofolate reductase (NADH) small subunit | 0 | 0 |
| K25008 | ion-translocating oxidoreductase complex subunit C [EC:7.-.-.-] | 0 | 0 |
| K25009 | methylenetetrahydrofolate reductase [NAD(P)H] [EC:1.5.1.20] | 0 | 0 |
| K25221 | [methyl-Co(III) glycine betaine-specific corrinoid protein]---tetrahydrofolate methyltransferase [EC:2.1.1.378] | 0 | 0 |
| K25915 | [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]---tetrahydrofolate methyltransferase [EC:2.1.1.385] | 0 | 0 |
| K26930 | [methyl-Co(III) quaternary-amine-specific corrinoid protein]---tetrahydrofolate methyltransferase [EC:2.1.1.389] | 0 | 0 |