K01649


Help to interpret the results

Three outputs have been generated:
General: this result contains the description and frequency of the selected Kegg Orthologs K01649, of which KO pathways and KO modules it is part. Additionally, its occurence in the database is reported.
Proteins list: list of occurences of the Kegg Orthologs within the database. 7 occurences are identified. The table reports the orthogroup, the organism in which each occurrence has been found, and the locus tag enriched by start and stop position, strand, gene name and product.
Clicking on the Ortohgroup name or locus you will be redirected to further info.
Profiles: Phylogenetic tree annotated with
- the presence of the Kegg Ortholog(s) of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Kegg Orthologs has been clustered.
In red the Kegg Orthologs with positive hit(s) in the corresponding genome.
In green the discrepencies between orthogroup clustering and Kegg Orthologs prediction. Green homologs (same orthogroup) are not positive hit(s) for the considered Kegg Orthologs.

Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Kegg Orthologs prediction.

Description

External link K01649
KO K01649
Description 2-isopropylmalate synthase [EC:2.3.3.13]

KO part of 6 pathways

Valine, leucine and isoleucine biosynthesis
Pyruvate metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
2-Oxocarboxylic acid metabolism
Biosynthesis of amino acids

KO part of 1 modules

M00432 Branched-chain amino acid metabolism Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate

Occurence in the database

K01649 is associated with 7 different proteins (see tab "Protein list" and "Profile")
The 7 proteins are classified into 1 different orthogroup(s)
# Orthogroup Locus Start Stop S. Gene Product Organism
0 group_869 PMI_RS10265 2250396 2251955 1 leuA 2-isopropylmalate synthase Proteus mirabilis HI4320
1 group_869 FBDBKF_04410 74654 76267 1 leuA 2-isopropylmalate synthase Morganella morganii S1
2 group_869 EHELCC_05700 134111 135724 1 leuA 2-isopropylmalate synthase Morganella morganii S2
3 group_869 NLDBIP_06020 175176 176789 1 leuA 2-isopropylmalate synthase Morganella morganii S4
4 group_869 LHKJJB_02900 152700 154313 1 leuA 2-isopropylmalate synthase Morganella morganii S3
5 group_869 HKOGLL_06375 74564 76177 1 leuA 2-isopropylmalate synthase Morganella morganii S5
6 group_869 F4V73_RS08855 1835788 1837374 1 leuA 2-isopropylmalate synthase Morganella psychrotolerans