Homologs in group_2473

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6 homologs were identified in 6 genomes with OrthoFinder.
The following table displays the locus tag of each homolog, the organism to which it belongs, the gene name and product.

Locus tag Identity Source Gene Product
FBDBKF_20345 FBDBKF_20345 100.0 Morganella morganii S1 birA bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA
EHELCC_19685 EHELCC_19685 100.0 Morganella morganii S2 birA bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA
NLDBIP_19670 NLDBIP_19670 100.0 Morganella morganii S4 birA bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA
HKOGLL_19550 HKOGLL_19550 100.0 Morganella morganii S5 birA bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA
F4V73_RS18870 F4V73_RS18870 88.7 Morganella psychrotolerans birA bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA
PMI_RS16095 PMI_RS16095 65.6 Proteus mirabilis HI4320 birA bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA

Distribution of the homologs in the orthogroup group_2473

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Number of homologs in each genome (first column) and amino-acid identity of the closest homolog (second column).

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Phylogeny of the RefSeq best hits of group_2473

Swissprot accession Eval Score ID (%) N gaps Alignment length Annot score Gene Description Organism
P37416 3.35e-154 437 66 0 317 3 birA Bifunctional ligase/repressor BirA Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
P06709 2.47e-149 425 64 0 317 1 birA Bifunctional ligase/repressor BirA Escherichia coli (strain K12)
P46363 3.79e-58 192 35 7 312 3 birA Bifunctional ligase/repressor BirA Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
E0U174 7.63e-33 127 32 10 315 3 birA Bifunctional ligase/repressor BirA Bacillus spizizenii (strain ATCC 23059 / NRRL B-14472 / W23)
P0CI75 4.89e-32 125 32 10 315 1 birA Bifunctional ligase/repressor BirA Bacillus subtilis (strain 168)
Q9JWI7 9.3e-21 96 29 11 279 3 birA/coaX Bifunctional enzyme BirA/CoaX Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)
P29906 1.33e-20 92 32 7 225 3 birA Biotin--[acetyl-CoA-carboxylase] ligase Paracoccus denitrificans
Q9JXF1 3.01e-19 91 29 10 277 3 birA/coaX Bifunctional enzyme BirA/CoaX Neisseria meningitidis serogroup B (strain ATCC BAA-335 / MC58)
Q5F5C8 5.77e-18 88 28 10 274 3 birA/coaX Bifunctional enzyme BirA/CoaX Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
I6YFP0 4.27e-15 77 29 8 244 1 birA Biotin--[acetyl-CoA-carboxylase] ligase Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
F4I4W2 1.66e-13 73 28 6 193 2 HCS2 Biotin--protein ligase 2 Arabidopsis thaliana
Q9SL92 3.71e-13 72 27 7 210 1 HCS1 Biotin--protein ligase 1, chloroplastic Arabidopsis thaliana
Q59014 7.41e-09 58 26 8 210 1 MJ1619 Putative biotin ligase Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
O14353 9.55e-08 57 25 13 257 3 bpl1 Biotin--protein ligase Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P50747 2.34e-06 52 33 5 109 1 HLCS Biotin--protein ligase Homo sapiens
Q920N2 0.000329 46 31 5 110 1 Hlcs Biotin--protein ligase Mus musculus

  • Number of RefSeq hits:

General

Source Morganella morganii S3
Locus tag LHKJJB_19630
Feature type CDS
Gene birA
Product bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA
Location 1555 - 2535 (strand: 1)
Length 981 (nucleotides) / 326 (amino acids)
In genomic island -

Contig

Accession ZDB_396
Length 4582 nucleotides
Topology linear
Plasmid False

Orthology

Orthogroup group_2473
Orthogroup size 7
N. genomes 7

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Genomic region

Domains

PF02237 Biotin protein ligase C terminal domain
PF03099 Biotin/lipoate A/B protein ligase family
PF08279 HTH domain

COG entry Annotation(s)

ID Function(s) descr. Function(s) cat. Description
COG0340 Coenzyme transport and metabolism (H) H Biotin-(acetyl-CoA carboxylase) ligase

Kegg Ortholog Annotation(s)

KO Description Pathways Modules
K03524 BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15] Biotin metabolism
Metabolic pathways		 -

Protein Sequence

MKDYSVPLTLIGILSDGEFHSGEQLGDKLGMTRAAVNKHIRTLREMGIEMETVTGKGYRLFAPMNLLQPDVIRTLLPGRNVEVLPVIGSTNQHMMDKVGELTSGDACVAEYQYAGRGRRGRQWISPFGRNLYLSLYWRLEQGPAAAIGLSLVVGIVLAETLHELGATGVKVKWPNDLYLDDKKLAGILVELQGKTGDAAHVVIGIGINLTMESSGTDQIGQQWINLQQSGIQIDRNILSAEFIKHLTDALHLFEKSGLTPFIERWYAFDNYLNREVKLIIGEREVFGVSRGINGQGALLLDQFGEITPYIGGEISLRGVNSKNKPA

Flanking regions ( +/- flanking 50bp)

GTCCGTTTTATCGGCACGGACGGTGAAATCTGTGCCACAGAGGCTATTGCATGAAAGATTACAGTGTACCGCTGACGCTGATCGGCATTTTATCCGACGGTGAGTTCCATTCCGGTGAACAACTCGGCGATAAGCTGGGGATGACCCGGGCCGCAGTTAATAAGCATATCCGCACATTACGCGAGATGGGTATAGAAATGGAAACGGTCACCGGTAAGGGTTACCGCCTCTTTGCACCGATGAATCTGTTACAGCCCGATGTTATCCGCACGCTGCTGCCCGGGCGAAATGTTGAAGTGCTGCCGGTCATCGGCTCCACCAATCAGCATATGATGGATAAAGTGGGGGAATTGACATCTGGTGATGCCTGTGTGGCGGAATACCAGTATGCCGGACGCGGTCGCCGCGGGCGGCAGTGGATCTCTCCGTTTGGCCGCAATCTGTATCTTTCTCTGTACTGGCGCCTTGAGCAGGGACCCGCAGCGGCTATCGGGCTGAGTCTGGTAGTCGGTATTGTGCTTGCTGAGACACTGCATGAGCTGGGTGCGACCGGTGTAAAAGTCAAATGGCCGAATGACTTATATCTGGATGACAAAAAACTGGCCGGGATCCTGGTCGAACTTCAGGGAAAAACCGGGGATGCCGCGCATGTGGTTATCGGGATCGGGATTAACCTGACCATGGAAAGTAGTGGTACAGATCAGATTGGCCAGCAGTGGATCAATCTGCAGCAATCCGGTATTCAGATTGACCGTAATATATTATCTGCAGAGTTTATTAAACATCTGACAGATGCGTTGCACTTGTTCGAAAAAAGCGGACTGACCCCGTTTATTGAACGCTGGTATGCTTTTGATAATTACCTTAATCGTGAAGTAAAACTGATTATTGGTGAGCGTGAGGTCTTTGGCGTTTCCAGAGGGATAAACGGGCAGGGTGCTTTGTTATTAGATCAGTTTGGTGAAATTACCCCCTATATCGGCGGAGAAATATCACTTCGTGGTGTGAATTCAAAAAATAAACCGGCCTGATCCGGTTTATTTTTAACAGAAAAACTGATTATTTCCGCAGTTTCACATTG