Homologs in group_2473

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6 homologs were identified in 6 genomes with OrthoFinder.
The following table displays the locus tag of each homolog, the organism to which it belongs, the gene name and product.

Locus tag Identity Source Gene Product
FBDBKF_20345 FBDBKF_20345 65.6 Morganella morganii S1 birA bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA
EHELCC_19685 EHELCC_19685 65.6 Morganella morganii S2 birA bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA
NLDBIP_19670 NLDBIP_19670 65.6 Morganella morganii S4 birA bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA
LHKJJB_19630 LHKJJB_19630 65.6 Morganella morganii S3 birA bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA
HKOGLL_19550 HKOGLL_19550 65.6 Morganella morganii S5 birA bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA
F4V73_RS18870 F4V73_RS18870 66.6 Morganella psychrotolerans birA bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA

Distribution of the homologs in the orthogroup group_2473

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Number of homologs in each genome (first column) and amino-acid identity of the closest homolog (second column).

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Phylogeny of the RefSeq best hits of group_2473

Swissprot accession Eval Score ID (%) N gaps Alignment length Annot score Gene Description Organism
P37416 2.89e-158 447 65 0 319 3 birA Bifunctional ligase/repressor BirA Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
P06709 5.01e-153 434 63 0 319 1 birA Bifunctional ligase/repressor BirA Escherichia coli (strain K12)
P46363 2.74e-57 190 36 7 310 3 birA Bifunctional ligase/repressor BirA Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
P0CI75 5.33e-29 116 27 4 309 1 birA Bifunctional ligase/repressor BirA Bacillus subtilis (strain 168)
E0U174 3.53e-28 114 27 4 309 3 birA Bifunctional ligase/repressor BirA Bacillus spizizenii (strain ATCC 23059 / NRRL B-14472 / W23)
Q9JWI7 1.44e-22 101 33 7 218 3 birA/coaX Bifunctional enzyme BirA/CoaX Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)
Q9JXF1 2.31e-22 100 33 7 218 3 birA/coaX Bifunctional enzyme BirA/CoaX Neisseria meningitidis serogroup B (strain ATCC BAA-335 / MC58)
P29906 1.06e-19 89 28 6 237 3 birA Biotin--[acetyl-CoA-carboxylase] ligase Paracoccus denitrificans
Q5F5C8 1.56e-18 89 31 7 217 3 birA/coaX Bifunctional enzyme BirA/CoaX Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
I6YFP0 5.28e-15 77 28 8 234 1 birA Biotin--[acetyl-CoA-carboxylase] ligase Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Q59014 1.63e-14 75 29 8 207 1 MJ1619 Putative biotin ligase Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
F4I4W2 2.33e-14 75 32 5 159 2 HCS2 Biotin--protein ligase 2 Arabidopsis thaliana
Q9SL92 4.46e-13 72 27 7 215 1 HCS1 Biotin--protein ligase 1, chloroplastic Arabidopsis thaliana
O14353 3.75e-09 61 27 12 283 3 bpl1 Biotin--protein ligase Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P50747 4.1e-07 55 26 8 182 1 HLCS Biotin--protein ligase Homo sapiens
Q920N2 4.31e-06 52 29 9 179 1 Hlcs Biotin--protein ligase Mus musculus

  • Number of RefSeq hits:

General

Source Proteus mirabilis HI4320
Locus tag PMI_RS16095
Feature type CDS
Gene birA
Product bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA
Location 3576871 - 3577833 (strand: 1)
Length 963 (nucleotides) / 320 (amino acids)
In genomic island -

Contig

Accession NC_010554
Length 4063606 nucleotides
Topology circular
Plasmid False

Orthology

Orthogroup group_2473
Orthogroup size 7
N. genomes 7

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Genomic region

Domains

PF02237 Biotin protein ligase C terminal domain
PF03099 Biotin/lipoate A/B protein ligase family
PF08279 HTH domain

COG entry Annotation(s)

ID Function(s) descr. Function(s) cat. Description
COG0340 Coenzyme transport and metabolism (H) H Biotin-(acetyl-CoA carboxylase) ligase

Kegg Ortholog Annotation(s)

KO Description Pathways Modules
K03524 BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15] Biotin metabolism
Metabolic pathways		 -

Protein Sequence

MKETSTPLLLINILADGELHSGEQLGESLGMTRAGINKHIKTLRSWGIDIHTVAGQGYQLDAPMNLLNSERVNRGIQGAPARVIPVIDSTNQYMIQRISELTSGDVCIAEYQSAGRGRRGRQWISPFGRNLYLSMYWKLDQGPAAAIGLSLVVGVILAEVLQQFGANGVKVKWPNDLYLNDKKLSGILVELTGKTGDVAHIVTGIGINIAMSNNQKDAINQQWINLEQVGIKIDRNQLACEITNALRKAFVQFEKQGLSAFIERWKSLDNFIDRRVKLIIGDKEIFGIAKGINEQGALLLEQNNKIVPYIGGEISLRSAP

Flanking regions ( +/- flanking 50bp)

GTGCGTTTTATTGGACGGCATGGCGAGATTAACGCGGTGGATGCTATTTCATGAAAGAGACATCAACTCCTCTATTACTCATCAATATCCTTGCTGATGGTGAGCTCCATTCAGGAGAACAATTAGGCGAAAGTTTGGGGATGACACGGGCAGGGATTAATAAGCATATCAAGACATTGCGTAGCTGGGGTATCGACATTCATACAGTGGCAGGTCAGGGTTATCAGCTAGATGCACCGATGAACCTGTTAAACAGTGAACGTGTCAATCGAGGCATTCAAGGTGCACCAGCTCGTGTGATACCGGTTATTGATTCAACTAACCAGTATATGATACAGCGTATTAGTGAATTAACCTCCGGTGATGTTTGTATTGCTGAATATCAATCTGCAGGGCGTGGGCGTAGAGGGCGGCAATGGATCTCTCCTTTTGGTCGTAATCTATATCTCAGTATGTATTGGAAATTGGATCAAGGACCTGCTGCCGCAATCGGGCTAAGTTTAGTTGTTGGTGTGATCCTTGCTGAAGTTTTACAGCAATTTGGTGCGAATGGTGTCAAAGTTAAATGGCCAAACGATCTTTACTTAAATGATAAAAAATTATCTGGGATCTTGGTTGAATTAACGGGAAAAACAGGTGATGTTGCGCATATTGTTACTGGCATTGGTATTAATATCGCCATGAGTAACAATCAAAAAGATGCAATAAACCAACAATGGATTAATTTAGAGCAGGTAGGGATAAAAATAGATAGGAATCAGTTGGCTTGTGAAATCACCAATGCGCTAAGAAAAGCATTTGTACAATTTGAAAAACAGGGGTTATCTGCTTTTATTGAACGTTGGAAAAGTTTAGATAATTTTATTGATAGGCGTGTTAAATTAATTATTGGTGACAAAGAGATCTTTGGTATCGCTAAAGGTATTAATGAGCAAGGGGCGTTACTTTTAGAACAAAACAATAAAATAGTACCCTATATTGGTGGTGAGATCTCGCTACGAAGTGCACCATAATTGGTTTATTTTGCTGCAATTTTCATATTAAAATATGCTCTCTAAAATAG