VFG004061


Help to interpret the results

Three outputs have been generated:
General: this tab contains the description, occurence in the database and other information related to the selected Virulence factor VFG004061
Protein list: lists the 7 occurences of the Virulence factor within the database. The table reports information on each occurence.
Profile: phylogenetic tree annotated with
- the presence of the Virulence factor of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Virulence factor has been clustered.
Orthogroups are shown in red if they are annotated with that particular Virulence factor in a given genome , in green otherwise, i.e. if there is a discrepency between orthogroup clustering and Virulence factor prediction.
Green homologs (same orthogroup) are not positive hit(s) for the considered Virulence factor.
Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Virulence factor prediction.

Description

Protein two-component system response regulator PhoP
VF ID VF0111
Category Regulation
Protein ID WP_001766960
Function Activated by low divalent cations magnesium and calcium levels; control expression of more than 40 genes; required for intracellular survival, cationic antimicrobial peptides (CAMPs) resistance, stimulation of cytokine secretion
Mechanism PhoQ contains distinct binding sites for Mg2+ and Ca2+, and is maximally repressed in the presence of both cations. PhoP-PO4 activates expression of pags (for PhoP-activated genes), including cation transporter, outer membrane proteins, nonspecific acid phosphatase, enzymes important for LPS modification, and pmrAB (a second two-component system that are activated in response to mildly acidic environment. PmrAB leads to an increased substitution of phosphates with 4-amino-4-deoxy-L-arabinose in both the core oligosaccharide and the lipid A components of LPS, these cations stabilize the outer membrane by neutralizing the negative charge of phosphate groups, PmrAB induced modification of LPS composition may be vital to maintenance of outer membrane integrity); represses transcription of prgs (for PhoP-repressed genes) required for epithelial cell invasion, including hilA, prgHIJKorgA operon; regulate acid tolerance response (ATR)
Vf_category_id VFC0301

Occurence in the database

VFG004061 is associated with 7 different proteins
The 7 proteins are classified into 1 different orthogroup(s)
Orthogroup Locus Start Stop S. Gene Product Organism
0 group_1980 FBDBKF_14575 9613 10287 1 phoP two-component system response regulator PhoP Morganella morganii S1
1 group_1980 EHELCC_15380 39689 40363 1 phoP two-component system response regulator PhoP Morganella morganii S2
2 group_1980 NLDBIP_15910 39689 40363 1 phoP two-component system response regulator PhoP Morganella morganii S4
3 group_1980 LHKJJB_15930 76323 76997 -1 phoP two-component system response regulator PhoP Morganella morganii S3
4 group_1980 HKOGLL_15050 75535 76209 -1 phoP two-component system response regulator PhoP Morganella morganii S5
5 group_1980 F4V73_RS07370 1537853 1538527 1 phoP two-component system response regulator PhoP Morganella psychrotolerans
6 group_1980 PMI_RS04350 977653 978327 -1 phoP two-component system response regulator PhoP Proteus mirabilis HI4320