VFG004061
Help to interpret the results
Three outputs have been generated:
General: this tab contains the description, occurence in the database and other information related to the selected Virulence factor VFG004061
Protein list: lists the 7 occurences of the Virulence factor within the database. The table reports information on each occurence.
Profile: phylogenetic tree annotated with
- the presence of the Virulence factor of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Virulence factor has been clustered.
Orthogroups are shown in red if they are annotated with that particular Virulence factor in a given genome , in green otherwise, i.e. if there is a discrepency between orthogroup clustering and Virulence factor prediction.
Green homologs (same orthogroup) are not positive hit(s) for the considered Virulence factor.
Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Virulence factor prediction.
Description
Protein |
two-component system response regulator PhoP |
VF ID |
VF0111 |
Category |
Regulation |
Protein ID |
WP_001766960 |
Function |
Activated by low divalent cations magnesium and calcium levels; control expression of more than 40 genes; required for intracellular survival, cationic antimicrobial peptides (CAMPs) resistance, stimulation of cytokine secretion |
Mechanism |
PhoQ contains distinct binding sites for Mg2+ and Ca2+, and is maximally repressed in the presence of both cations. PhoP-PO4 activates expression of pags (for PhoP-activated genes), including cation transporter, outer membrane proteins, nonspecific acid phosphatase, enzymes important for LPS modification, and pmrAB (a second two-component system that are activated in response to mildly acidic environment. PmrAB leads to an increased substitution of phosphates with 4-amino-4-deoxy-L-arabinose in both the core oligosaccharide and the lipid A components of LPS, these cations stabilize the outer membrane by neutralizing the negative charge of phosphate groups, PmrAB induced modification of LPS composition may be vital to maintenance of outer membrane integrity); represses transcription of prgs (for PhoP-repressed genes) required for epithelial cell invasion, including hilA, prgHIJKorgA operon; regulate acid tolerance response (ATR) |
Vf_category_id |
VFC0301 |
Occurence in the database
VFG004061 is associated with 7 different
proteins
|
The 7 proteins are classified into 1 different orthogroup(s)
|
|
Orthogroup |
Locus |
Start |
Stop |
S. |
Gene |
Product |
Organism |
0 |
group_1980 |
FBDBKF_14575 |
9613 |
10287 |
1 |
phoP |
two-component system response regulator PhoP |
Morganella morganii S1 |
1 |
group_1980 |
EHELCC_15380 |
39689 |
40363 |
1 |
phoP |
two-component system response regulator PhoP |
Morganella morganii S2 |
2 |
group_1980 |
NLDBIP_15910 |
39689 |
40363 |
1 |
phoP |
two-component system response regulator PhoP |
Morganella morganii S4 |
3 |
group_1980 |
LHKJJB_15930 |
76323 |
76997 |
-1 |
phoP |
two-component system response regulator PhoP |
Morganella morganii S3 |
4 |
group_1980 |
HKOGLL_15050 |
75535 |
76209 |
-1 |
phoP |
two-component system response regulator PhoP |
Morganella morganii S5 |
5 |
group_1980 |
F4V73_RS07370 |
1537853 |
1538527 |
1 |
phoP |
two-component system response regulator PhoP |
Morganella psychrotolerans |
6 |
group_1980 |
PMI_RS04350 |
977653 |
978327 |
-1 |
phoP |
two-component system response regulator PhoP |
Proteus mirabilis HI4320 |