K00873


Help to interpret the results

Three outputs have been generated:
General: this result contains the description and frequency of the selected Kegg Orthologs K00873, of which KO pathways and KO modules it is part. Additionally, its occurence in the database is reported.
Proteins list: list of occurences of the Kegg Orthologs within the database. 15 occurences are identified. The table reports the orthogroup, the organism in which each occurrence has been found, and the locus tag enriched by start and stop position, strand, gene name and product.
Clicking on the Ortohgroup name or locus you will be redirected to further info.
Profiles: Phylogenetic tree annotated with
- the presence of the Kegg Ortholog(s) of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Kegg Orthologs has been clustered.
In red the Kegg Orthologs with positive hit(s) in the corresponding genome.
In green the discrepencies between orthogroup clustering and Kegg Orthologs prediction. Green homologs (same orthogroup) are not positive hit(s) for the considered Kegg Orthologs.

Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Kegg Orthologs prediction.

Description

External link K00873
KO K00873
Description pyruvate kinase [EC:2.7.1.40]

KO part of 12 pathways

Glycolysis / Gluconeogenesis
Pyruvate metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Carbon metabolism
Biosynthesis of amino acids
Glucagon signaling pathway
Type II diabetes mellitus
Human papillomavirus infection
Viral carcinogenesis
Central carbon metabolism in cancer

KO part of 2 modules

M00001 Central carbohydrate metabolism Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
M00002 Central carbohydrate metabolism Glycolysis, core module involving three-carbon compounds

Occurence in the database

K00873 is associated with 15 different proteins (see tab "Protein list" and "Profile")
The 15 proteins are classified into 2 different orthogroup(s)
# Orthogroup Locus Start Stop S. Gene Product Organism
0 group_240 PMI_RS05575 1215704 1217146 -1 pyk pyruvate kinase Proteus mirabilis HI4320
1 group_1027 PMI_RS06795 1482432 1483844 1 pykF pyruvate kinase PykF Proteus mirabilis HI4320
2 group_240 PMI_RS11920 2634314 2635765 1 pyk pyruvate kinase Proteus mirabilis HI4320
3 group_240 FBDBKF_02100 108274 109716 -1 pyk pyruvate kinase Morganella morganii S1
4 group_240 EHELCC_02570 496094 497536 -1 pyk pyruvate kinase Morganella morganii S2
5 group_240 NLDBIP_00890 182600 184042 1 pyk pyruvate kinase Morganella morganii S4
6 group_240 LHKJJB_01145 208643 210085 -1 pyk pyruvate kinase Morganella morganii S3
7 group_240 HKOGLL_01185 214154 215596 -1 pyk pyruvate kinase Morganella morganii S5
8 group_1027 FBDBKF_05790 160399 161811 1 pykF pyruvate kinase PykF Morganella morganii S1
9 group_1027 EHELCC_11800 19683 21095 -1 pykF pyruvate kinase PykF Morganella morganii S2
10 group_1027 NLDBIP_12140 19638 21050 -1 pykF pyruvate kinase PykF Morganella morganii S4
11 group_1027 LHKJJB_12000 19683 21095 -1 pykF pyruvate kinase PykF Morganella morganii S3
12 group_1027 HKOGLL_10615 19683 21095 -1 pykF pyruvate kinase PykF Morganella morganii S5
13 group_1027 F4V73_RS03535 755674 757086 -1 pykF pyruvate kinase PykF Morganella psychrotolerans
14 group_240 F4V73_RS04465 944460 945902 -1 pyk pyruvate kinase Morganella psychrotolerans