Homologs in group_3133

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5 homologs were identified in 1 genome with OrthoFinder.
The following table displays the locus tag of each homolog, the organism to which it belongs, the gene name and product.

Locus tag Identity Source Gene Product
PMI_RS00020 PMI_RS00020 27.9 Proteus mirabilis HI4320 - calcium-binding protein
PMI_RS01360 PMI_RS01360 33.2 Proteus mirabilis HI4320 - M10 family metallopeptidase
PMI_RS01365 PMI_RS01365 33.1 Proteus mirabilis HI4320 - M10 family metallopeptidase C-terminal domain-containing protein
PMI_RS01370 PMI_RS01370 34.4 Proteus mirabilis HI4320 - M10 family metallopeptidase C-terminal domain-containing protein
PMI_RS01375 PMI_RS01375 33.2 Proteus mirabilis HI4320 - M10 family metallopeptidase C-terminal domain-containing protein

Distribution of the homologs in the orthogroup group_3133

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Number of homologs in each genome (first column) and amino-acid identity of the closest homolog (second column).

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Phylogeny of the RefSeq best hits of group_3133

Swissprot accession Eval Score ID (%) N gaps Alignment length Annot score Gene Description Organism
Q9KS12 0.0 2316 53 18 2128 1 rtxA Multifunctional-autoprocessing repeats-in-toxin Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Q9KS12 0.0 1719 48 37 2086 1 rtxA Multifunctional-autoprocessing repeats-in-toxin Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Q9KS12 4.45e-138 493 39 9 706 1 rtxA Multifunctional-autoprocessing repeats-in-toxin Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
A0A2S3R7M0 0.0 1724 48 31 2033 1 CRN52_02910 Multifunctional-autoprocessing repeats-in-toxin Vibrio vulnificus
A0A2S3R7M0 0.0 1517 63 6 1126 1 CRN52_02910 Multifunctional-autoprocessing repeats-in-toxin Vibrio vulnificus
A0A2S3R7M0 0.0 833 44 10 949 1 CRN52_02910 Multifunctional-autoprocessing repeats-in-toxin Vibrio vulnificus
A0A2S3R7M0 2.68e-145 518 40 8 710 1 CRN52_02910 Multifunctional-autoprocessing repeats-in-toxin Vibrio vulnificus
Q6IRP4 1.27e-08 63 32 2 92 2 abhd13 Protein ABHD13 Xenopus laevis
Q08C93 6.98e-08 62 29 3 119 2 abhd12 Lysophosphatidylserine lipase ABHD12 Danio rerio
P08715 3.22e-07 60 33 8 165 1 hlyA Hemolysin, plasmid Escherichia coli
Q7Z5M8 5.81e-07 58 28 3 121 1 ABHD12B Protein ABHD12B Homo sapiens
Q32LS6 7.54e-07 58 28 2 92 2 abhd13 Protein ABHD13 Danio rerio
T0D3N5 2.02e-06 58 24 10 245 1 tcsL Cytotoxin-L Paraclostridium sordellii (strain ATCC 9714 / DSM 2141 / JCM 3814 / LMG 15708 / NCIMB 10717 / 211)
Q46342 2.21e-06 58 24 10 245 1 tcsL Cytotoxin-L Paraclostridium sordellii
P54069 3.03e-06 56 23 6 202 2 bem46 Protein bem46 Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q6AY17 3.39e-06 55 29 4 141 1 Abhd17b Alpha/beta hydrolase domain-containing protein 17B Rattus norvegicus
Q7M759 3.39e-06 55 29 4 141 1 Abhd17b Alpha/beta hydrolase domain-containing protein 17B Mus musculus
Q5ZJL8 4.93e-06 55 25 2 93 2 ABHD13 Protein ABHD13 Gallus gallus
Q5VST6 4.99e-06 55 29 4 141 1 ABHD17B Alpha/beta hydrolase domain-containing protein 17B Homo sapiens
Q7ZVZ7 5.43e-06 55 33 2 92 2 abhd17c Alpha/beta hydrolase domain-containing protein 17C Danio rerio
Q5XIJ5 5.47e-06 55 30 6 153 1 Abhd17a Alpha/beta hydrolase domain-containing protein 17A Rattus norvegicus
Q99JW1 5.47e-06 55 30 6 153 1 Abhd17a Alpha/beta hydrolase domain-containing protein 17A Mus musculus
B4F753 5.75e-06 55 28 3 124 2 abhd12 Lysophosphatidylserine lipase ABHD12 Xenopus tropicalis
Q80UX8 1.29e-05 54 24 2 93 2 Abhd13 Protein ABHD13 Mus musculus
Q99LR1 1.64e-05 54 26 3 124 1 Abhd12 Lysophosphatidylserine lipase ABHD12 Mus musculus
Q6AYT7 1.77e-05 54 26 3 124 2 Abhd12 Lysophosphatidylserine lipase ABHD12 Rattus norvegicus
Q5ZIN0 2.11e-05 53 27 4 136 2 ABHD12 Lysophosphatidylserine lipase ABHD12 Gallus gallus
P9WLC7 2.22e-05 53 33 1 86 1 Rv2307c Uncharacterized protein Rv2307c Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WLC6 2.22e-05 53 33 1 86 4 MT2364 Uncharacterized protein MT2364 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Q6DCC5 2.56e-05 53 31 3 112 2 abhd17b Alpha/beta hydrolase domain-containing protein 17B Xenopus laevis
Q4R766 2.6e-05 53 26 3 124 2 ABHD12 Lysophosphatidylserine lipase ABHD12 Macaca fascicularis
Q6GL10 2.67e-05 53 33 2 92 2 abhd17c Alpha/beta hydrolase domain-containing protein 17C Xenopus tropicalis
Q8N2K0 2.81e-05 53 26 3 124 1 ABHD12 Lysophosphatidylserine lipase ABHD12 Homo sapiens
Q96GS6 3.13e-05 53 32 3 112 1 ABHD17A Alpha/beta hydrolase domain-containing protein 17A Homo sapiens
Q5ZJX1 3.16e-05 53 32 2 94 2 ABHD17C Alpha/beta hydrolase domain-containing protein 17C Gallus gallus
P16462 3.38e-05 54 26 9 229 1 ltxA Leukotoxin Aggregatibacter actinomycetemcomitans
Q5ZJ01 3.87e-05 52 29 4 141 2 ABHD17B Alpha/beta hydrolase domain-containing protein 17B Gallus gallus
B5DFK7 4.41e-05 52 31 2 94 1 Abhd17c Alpha/beta hydrolase domain-containing protein 17C Rattus norvegicus
Q8VCV1 4.41e-05 52 31 2 94 1 Abhd17c Alpha/beta hydrolase domain-containing protein 17C Mus musculus
Q6PCB6 4.62e-05 52 31 2 94 1 ABHD17C Alpha/beta hydrolase domain-containing protein 17C Homo sapiens
A5PKD9 4.62e-05 52 31 2 94 2 ABHD17C Alpha/beta hydrolase domain-containing protein 17C Bos taurus
Q5UP55 5.88e-05 52 24 5 178 4 MIMI_R595 Uncharacterized protein R595 Acanthamoeba polyphaga mimivirus
Q6DD70 6.76e-05 52 32 2 92 2 abhd17c Alpha/beta hydrolase domain-containing protein 17C Xenopus laevis
Q5UQK4 6.96e-05 51 31 1 91 3 MIMI_L404 Putative alpha/beta hydrolase L404 Acanthamoeba polyphaga mimivirus
Q2HJ19 8.1e-05 51 28 6 153 2 ABHD17A Alpha/beta hydrolase domain-containing protein 17A Bos taurus
Q7L211 8.8e-05 52 27 2 87 1 ABHD13 Protein ABHD13 Homo sapiens
Q21221 8.83e-05 52 28 1 108 1 aho-3 Alpha/beta hydrolase domain-containing protein aho-3 Caenorhabditis elegans
Q08DW9 9.87e-05 52 25 3 124 2 ABHD12 Lysophosphatidylserine lipase ABHD12 Bos taurus
Q6DEY3 0.000158 50 28 4 141 2 abhd17b Alpha/beta hydrolase domain-containing protein 17B Xenopus tropicalis
P42840 0.000314 49 29 2 105 1 YNL320W Uncharacterized membrane protein YNL320W Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P0DKX7 0.000757 50 30 8 210 1 cya Bifunctional hemolysin/adenylate cyclase Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
J7QLC0 0.000757 50 30 8 210 1 cya Bifunctional hemolysin/adenylate cyclase Bordetella pertussis (strain ATCC 9797 / DSM 5571 / CCUG 30873 / LMG 14455 / NCTC 10739 / 18323)
P09983 0.000811 49 32 7 164 1 hlyA Hemolysin, chromosomal Escherichia coli

  • Number of RefSeq hits:

General

Source Proteus mirabilis HI4320
Locus tag PMI_RS10070
Feature type CDS
Gene rtxA
Product MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin RtxA
Location 2185086 - 2198945 (strand: 1)
Length 13860 (nucleotides) / 4619 (amino acids)

Contig

Accession NC_010554
Length 4063606 nucleotides
Topology circular
Plasmid False

Orthology

Orthogroup group_3133
Orthogroup size 6
N. genomes 1

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Genomic region

Domains

PF07634 RtxA repeat
PF11647 Membrane Localization Domain
PF11713 Peptidase C80 family
PF12146 Serine aminopeptidase, S33

COG entry Annotation(s)

ID Function(s) descr. Function(s) cat. Description
COG1073 Signal transduction mechanisms (T) T Fermentation-respiration switch esterase FrsA, DUF1100 family

Kegg Ortholog Annotation(s)

Protein Sequence

MSKILKDLEFTFTGKRYGTDGNDDIDAIGFGGIIYAGKGHDTITVGTFAVTAYTGDGHDFVRGGSAYLKIIDENGDLDVRGLNAWGEIEKSGHGDLKYVGASAAIKINHTGYEYGNINYSGAAIANIITRKGAISNINYQGAGGYNQIWHETNTGNMTFKGGGGYNKLVRTWFNSYQNSKGNINFEGLGGGNGIFSRVETGDIKFTGGGLENVLIREGKSGDIFMYGAGANNRLTRISRNTDTYKETSGNIYFSGGGGYNHIYSNIAQGNITFYGAGAYNEIIRTTQVHPHNDLLVEYTKAENIFLTSAYMLNLDLDKSINFLTSDNKQNFESGKPVEVKAIKSLREPNTYLFKTPGPGDTNLFISDYGRRDYTFNKVKIYNDPETGKLQYDSELWRITPDSGDIRNIRFDKKNFEDTYNLSVVNNCWNTLEKQEIIESPRFTKINADSHYQLSNLKVFQHINTEQIQRKSLETIKLGVAQELFKDDNSAECSGDINFTGGGAGNVIKSDVTQGDINFTGGGIANVIKHNSNYGNTNFTGGGAANIIVKKGQRGDLTFDGGGLANVLLHQSKEGRMNINATGATNVLIRIGDGEYKAHLTALGNVSIHKGQGDSHITMLGGLNTHTQIDSHQRDKALWRALGGLNVMTQVGAGTITSLLGGGGNVLTKMGEGDLSSIMLGGANIITHISNNKIKSNTYTITLGGLNILTKKGQGDILAIMGGGGNVLTHIGNGNIHGVMLGGANILTKVGNGDLSGIMLGIGNVLTHVGDGQTLGIMGAVGNIFTKVGNGTSMGAMVGGGNIFTHIGNGEAWALMGGLGNVYTKIGNGNTLALMIAKGNVFTHVGDGMSVALMLAIGNIATKVGDGMTLAAMIGSANIFTHIGHEETFAAMVGKGNVLTKVGNGLTLGLMLGVANIYTHVGDGISIGLFSGKANIMTKVGNGTTLSAMFGKANIMTHIGDGITGILALGQANIITKVGDGIAGIIAGAKGNIVTHVGDGITAAILGGKANILTKVGDGLTVGLLISKVGNIMTHIGNSTTIGFAKGNANIITKVGYGLGINAAWGKANIFTHIGDGERYNFAKGNANIITKVGNGQETSVVKGNINIITHVGSGNNYTGAWGNGNVVTQIGDGRQVALAKGHANIVTMLGKGDNYGIVWGKANISTKVGNGTQVTIAKGQANITTTVGDGLGVTVTYGNANINTKVGNGVSVNVAWGKYNVSTKVGDGLNVSVMKGTANANIHVGNGLGINASYAKNNVIVKIGNGDIYSLSVASSNTQSNKLATFFGNIKQSVLGVVGSQAINYLVQGDDVTTSGSRKGKGAIHLIEKSSIDGFKMNKIDEVKSNIDINLKGHITEVETPSLSDVNTDESNLTNNSPNLIINGDFKHGFKPVTEGWNIAYTQDKITAISQYGHRASIDTPTNTNNKDYWDGGLIAEYKEEYEPNIAIYQDISGLMQNEVIELSFEYERQDNTPTENKLSVIWNGEVVFTSSSDDKSIAWQQQQIKLTANAENNRLIFTIPGSDGLQGNNYRLRNIVAKSAVANINKHISDSDATKNALADKKKADANRQKLTDEKQRLLDHISTTQTELESTDHLALEKNGHRERDAILEEANSVTHNLTTVGQTLEVLSEYSQDAPPSDQPWSEPFAEGILKDVQKSLINTKKIVSVPVNNIKTQYVANLTKVKKSIKKSEYGVIQSEEHCQEVQLDTSKAKNDADKRYSDAIDKKNSAQMAEKKASTMVEDARSRGDTEQKTATSISDKAQKEAKSVQLKESDKPNRHRAHGSGLSGEAAYVEGADDNPSSYIKPISTKKNDGRFNNKLTTFNQELLDDAQQAINRLSINAGIRQKSANVLPSFTSDLNGDDVATYQQPSLRSGNLQYHKIGAIAVNLSGLGESPIFETLKQKFNVKIKNRNTYFTFILEKNSGRIQKNIYLDNINDPTQQKIIEHFILANYSNFEAMPNELHLENDKIKSSHNNKDRILAEYVEHKWQMLTDSKVMSVDELHKVASVKGKIQGESYKSIITTLSEYHEKESNTNCLPIEKLRVLAQLRNQIDGYLLGHPDSERNDGLKQLQTQVNTRYKHASALIQDSHTINADSSFSRLYDSLSNANLKRSKHIYIDINGHFVTEGKNNLQGKNRLTSGKEVIERVKNAVEKEYGAPIANKVFSQFANNEFAENGEGIDVSGLKKIHRAIERELSPHSATLYIWKPSNHSNLGHATLQIGQGRLLLNTEDAQNNHKENYISWWPNKAKSYFDVMGVPSQPKESLASDVAAEENDGFGLNYKYKELNRYDRLMNIAKGETVTTADDLSLADAKNILTIPNYIENSKIPRTIGQPFIDEWVITQKKLNNIATNFLEAVQGKFSGNTITINGAMILLTEPTLLSKRKIPLSVAQPFIEQWDNIKTQQEDISIQLLKAMKTWIQEGKDPTLTKKRIALVENEFAEQKQKSIDRFKTSLPDEGRVFRINLEGLDVAAMQAEWQRIKNSPNGRYHLLTQNCSSIVAKILKAGGADELIGYNWQPKYNIWTPNQMFAFAQELQEAQMARQQSRMIPPNLHALSGSENIRQELENTSPLISAEQKLNIVFSEQETGFLLTQASDETNEKFIYIKNGDNQEQQKIMSNFILTHYRDFDSIPEQLYFLDNTIVSLDKNHSRILSEKVGENWQPVAYSNLMTADELTSAAEVTGKARGENYKAIIQSLRDYELQSTNTNNTPIDIFQQLSTLRIQINSYLLKHPDSKRNEALQQLRDQVDIRYKHASILLSNSQQVDSNNTFSYLYEIFSNANLKINKHIYLDENGNFVTKGKNNLQNQDKLISGKNAITSIKRLVEKEYGSEITNQVFNQFTENEFAQNGHGIDLSGLKKIHQAIEQQVSPISSTLYIWKPSKHSRLGHAALQIGSGRLQLDSDSVQDNHDNNYVSWWPAGSKSLANPLNITTEKNPDLKLRWYDLSQPVSRSTNFMTLQIDIQEEEKTNFKLNKDEGENDRQLKEFRDKTNLTRGLENITPEIAGLLLKAPHLIPETLIPPEISHPFIKQWKSPNSNLLEVSTNFSIAVKNWLKVAFPTAMINQTFALEIKKIKEIEDRKTENFKTSVADDTNDGVVFRINLEGLDAAAMQKEWKRINSQSDPRYQLLTKNCSSIVARILKAGGADQLIGHHWKPRFGIWTPNELYKFSQKIQEARLAQIAVQQGKPIHSNLQALSDHNKVAIDNDGTSPNERKNLSPLTRFFNDHFFGSYERRRDMTTVMRIKNEEKITLKGDAGRLTGSYYRGNDNIPEATDKKVVLFLHGSNSPTEKQSSSFYHYYNQQGIDMLAINMRGFGESDGSPTEQGMYADAQTMFRYLVNDKGIDPKNIIIHGYSMGAPIAAKLASDISANGQHIAGLFLDRPMPSMSKAIESYDEYSLKKLTGQLAKKINGQFSVEKNLQGFSKDIPIILLTDCGELGIGGEKMRTKLLDKGYLVKGERTDVSHLESLKLMNQYGKQIISSLLSPEYVNNTNHRNALDSIQNPIKKNKVTDWGMVYVKPNDNGGDSRFDSQIIIQTEDDPIVAQAASALAAKHAKNSIVVQLDADGHYRVAYGDPAQLSGKIRWQLVGHGRETTENNHLRLSNYNADELSNQLVKFNTVFSKENNINTTPEHISIVGCSLISNDKQAGFAHQFINALDQQGIRSSVSARVTEVAVDSNGHKYTKDNNGEWVAKQTQNKVVLDWNKEGKITTEFEQIHNGVAEGDIDLTKVGASADNKVRGAIADNNEVFTAPKKGKKSTKQSSSGSDNSSLSYSGNIQVSVGDGEFTTVNWGTSNLGIKVGTGGFKSLVFGDNNVMVHVGNGDSKHSVDIAGYQAFEGMQLFVGTRNVSFNLGRSNDLIVMLEKSIPTPPLINPFDGAARITKVLESIACSGENNDNDWLSVQNDQWTLAGAKKFAIDMSGIDQTSNVDYKTLTDLNSQNKRSSRGLKSDLEATLNKKYNQWLGGSGNNNEMGKISRAEQLRQLDSKIAFNFAIGGQGADIQVTAGNWNLMFGDNIQSIIDTNLGSLFGLMTQQFTATGMVETTFTYTPQNLPTKLKNKLLGRLASVSSDTTLGDIFGVDSTTDGKIISRNGEPIDVVAILKDMLAVVTEFGGEKLSAFTDPTKLLDNLQSSINLGKDGIISFAESHGLKEKATEDQQNESEVSINAQTPITTSQTENSKITEENDRPFGFNSLNIPNLFATIFNKDKQTDMRDLAENLKENLAADVLNMEKKTLDFLRNSGHLKGDGDIHVSLGNYNFNWGGDGNDLGAYLGDNNNFWGGRGSDTFYATGISNIFTGGYGNDLGVLMGRSNMMFGGDGDDTAIIAGRINNVYLGDGLDKAFVFGEGGEIHTNAGNDYVVTTGNYNRIFSGSEQDFVVTIGNHNQISLEEGNDFAKIFGNYNRLNGGGGDDEIQLMGYHAVVDGGDGNDQLIAASFSKFSLLNGNTGNDIIILGGYQNHFKGGNGIDSFLINNNVIDCYIDDISQEDNIVLGDIDWNKLWFERSGYDLKISHIRFPQNTGEQATFERIGSTTFTDYFNGNQAKIVIAMTDKDHSDQREYTALSSNALAIQIQAMSTFPMKAGASGFFDNISDEAKQMIAVAWTDTISGKGILV

Flanking regions ( +/- flanking 50bp)

TATTTAAAAATTACTGTACTTTTTATTAAAAATAAGTTTGAGGGAAAATGATGTCAAAAATTTTAAAAGATTTAGAGTTTACTTTTACAGGAAAACGTTATGGTACAGATGGAAATGACGATATTGATGCCATAGGTTTTGGAGGGATCATTTATGCAGGAAAGGGACACGATACAATCACAGTCGGAACATTTGCAGTTACCGCTTACACCGGAGACGGGCACGATTTTGTCAGAGGGGGAAGTGCTTATCTTAAGATTATTGATGAGAACGGTGATTTAGATGTCAGAGGATTAAATGCATGGGGAGAAATTGAAAAGTCCGGTCATGGCGATCTGAAATATGTTGGTGCTTCTGCCGCGATTAAGATTAATCATACTGGATATGAATATGGAAATATCAATTATTCAGGAGCTGCTATTGCAAATATCATCACCCGTAAAGGCGCAATTAGTAATATCAACTACCAAGGTGCTGGCGGTTACAATCAAATTTGGCATGAAACCAATACTGGCAATATGACGTTTAAAGGGGGGGGAGGCTATAATAAATTGGTTCGTACTTGGTTTAATAGCTATCAAAATTCAAAAGGAAATATTAATTTTGAAGGATTAGGCGGAGGCAACGGAATCTTCTCTCGCGTTGAAACAGGTGATATTAAATTTACCGGAGGTGGCTTAGAAAACGTCTTAATACGCGAAGGTAAATCAGGCGATATCTTTATGTATGGAGCAGGAGCCAATAATAGGCTTACACGTATCAGCCGAAATACTGATACCTATAAAGAAACAAGTGGCAATATCTATTTTTCGGGGGGGGGAGGTTATAATCATATCTATTCCAATATAGCACAAGGCAATATCACATTTTATGGAGCTGGGGCTTACAATGAGATCATTCGTACAACTCAAGTTCATCCTCATAATGATTTATTAGTTGAATATACGAAAGCTGAAAATATTTTTCTAACAAGTGCTTATATGTTAAATCTAGACTTAGATAAAAGTATTAATTTTCTAACAAGTGATAATAAGCAAAATTTCGAATCCGGTAAACCTGTTGAAGTAAAAGCGATTAAATCATTGCGAGAACCAAATACTTATTTGTTTAAAACACCGGGCCCAGGGGATACCAATTTATTCATATCAGACTATGGTCGTCGAGATTATACCTTTAATAAAGTCAAAATTTACAATGATCCTGAAACGGGAAAACTTCAATACGATTCCGAACTTTGGCGTATAACGCCTGATAGTGGGGACATTAGGAACATACGTTTTGATAAAAAAAATTTTGAGGATACCTATAATCTTAGTGTGGTCAATAATTGTTGGAATACATTAGAAAAACAAGAAATTATCGAATCACCACGTTTCACAAAAATAAATGCTGATAGCCACTATCAATTATCTAATTTAAAAGTATTTCAACACATTAATACAGAACAAATCCAAAGAAAGTCTCTAGAAACAATCAAGTTGGGCGTAGCACAAGAACTTTTTAAAGACGATAATTCTGCTGAATGCTCTGGTGATATCAATTTCACAGGTGGTGGCGCTGGTAATGTCATTAAATCTGATGTTACACAAGGTGATATCAATTTTACAGGTGGCGGCATAGCAAATGTAATAAAACATAACTCTAATTATGGTAATACCAACTTTACTGGTGGAGGCGCAGCCAACATCATTGTAAAAAAAGGTCAAAGAGGAGACCTAACATTTGATGGAGGAGGATTAGCAAATGTCTTACTACATCAAAGTAAAGAAGGAAGAATGAACATTAATGCTACTGGTGCCACGAATGTATTAATCCGAATTGGTGACGGTGAATATAAAGCACATCTTACGGCATTAGGGAATGTTTCTATTCACAAAGGACAAGGTGATAGTCATATCACAATGTTAGGAGGATTAAATACCCATACCCAGATTGATAGTCATCAGCGTGATAAGGCTTTATGGCGAGCATTAGGCGGACTTAATGTCATGACACAAGTCGGTGCTGGTACTATTACATCTTTACTCGGCGGCGGTGGAAATGTCCTGACTAAAATGGGTGAAGGCGACCTAAGTAGCATCATGTTAGGTGGTGCTAATATCATTACACATATCAGCAATAACAAAATAAAATCAAATACTTACACTATCACCCTAGGTGGATTAAATATTTTAACAAAAAAAGGTCAAGGTGATATTTTAGCCATAATGGGGGGAGGTGGCAATGTCCTAACACATATCGGAAACGGTAACATACATGGCGTTATGCTTGGAGGTGCCAATATCTTAACTAAAGTAGGTAATGGTGATCTTTCAGGCATTATGCTAGGTATTGGTAATGTACTAACACATGTTGGCGATGGGCAAACCCTAGGTATAATGGGCGCTGTGGGGAATATTTTCACTAAAGTCGGTAATGGAACCAGTATGGGTGCCATGGTCGGTGGTGGCAATATATTCACCCATATAGGTAATGGTGAAGCTTGGGCACTAATGGGAGGTTTAGGCAACGTCTATACCAAAATAGGCAATGGGAATACTTTGGCACTAATGATCGCCAAAGGGAATGTGTTCACTCATGTGGGTGATGGAATGTCGGTTGCTCTAATGTTAGCGATAGGCAATATAGCCACAAAAGTGGGCGATGGCATGACATTAGCTGCAATGATTGGCAGTGCTAATATTTTTACTCACATTGGGCATGAAGAAACCTTTGCTGCAATGGTGGGTAAAGGTAATGTCCTTACCAAAGTTGGCAATGGATTAACATTGGGATTAATGCTAGGTGTGGCTAATATTTATACCCATGTCGGTGATGGCATTAGTATTGGGCTGTTTTCTGGTAAAGCAAATATCATGACCAAAGTGGGTAATGGAACCACATTATCAGCGATGTTTGGCAAAGCCAATATTATGACCCATATCGGTGATGGGATAACTGGCATACTTGCATTAGGCCAAGCCAATATCATAACAAAAGTGGGTGATGGCATTGCGGGAATCATTGCTGGTGCGAAAGGAAATATCGTTACTCATGTAGGTGATGGAATAACCGCTGCGATCCTCGGCGGAAAAGCGAATATTTTAACAAAAGTGGGTGATGGGCTCACCGTAGGTCTGCTGATTTCAAAGGTGGGAAATATTATGACCCATATTGGTAATAGCACCACGATTGGTTTTGCCAAAGGCAACGCCAATATCATCACAAAAGTAGGCTATGGTTTAGGCATTAATGCGGCATGGGGTAAAGCTAATATTTTCACTCATATCGGCGATGGTGAACGATATAACTTCGCCAAAGGAAATGCCAACATCATTACCAAAGTAGGTAATGGACAAGAAACCTCTGTTGTTAAAGGTAATATCAATATTATTACACACGTAGGTAGTGGAAATAATTATACTGGTGCATGGGGCAATGGGAATGTTGTAACACAAATTGGTGATGGTCGTCAGGTCGCCTTAGCAAAAGGTCATGCAAATATTGTCACTATGCTCGGAAAAGGTGACAACTATGGCATAGTTTGGGGTAAAGCCAATATTTCGACAAAAGTAGGTAATGGCACGCAAGTCACCATAGCAAAAGGCCAAGCAAATATTACAACAACCGTAGGTGATGGCCTAGGTGTTACCGTTACATACGGCAACGCAAATATCAATACTAAAGTGGGGAATGGTGTATCTGTAAACGTTGCTTGGGGGAAATATAACGTAAGTACCAAAGTGGGTGACGGCTTAAATGTTTCGGTCATGAAAGGTACCGCTAATGCAAATATCCATGTTGGTAACGGTTTAGGTATTAACGCCTCTTACGCAAAAAACAATGTCATCGTTAAAATTGGCAATGGTGATATCTACAGCTTATCGGTTGCTTCTAGTAATACTCAAAGTAATAAACTCGCTACTTTCTTCGGCAATATAAAACAGAGTGTACTTGGTGTGGTCGGGAGTCAGGCTATTAACTATTTAGTACAAGGTGATGATGTAACCACTTCCGGCTCCCGCAAAGGCAAAGGCGCTATTCATTTAATTGAAAAATCTTCAATCGACGGTTTCAAAATGAACAAAATCGACGAAGTGAAGAGTAACATTGATATAAATTTAAAAGGTCATATCACAGAGGTAGAAACCCCTAGTTTAAGTGATGTTAATACAGATGAATCCAACTTAACCAATAACAGTCCGAATTTGATCATAAATGGTGACTTTAAACATGGATTTAAACCTGTAACAGAAGGTTGGAATATTGCATATACTCAGGATAAAATTACAGCAATTAGCCAATATGGACATAGAGCCTCTATTGATACACCAACTAATACTAATAATAAAGATTATTGGGATGGTGGACTTATAGCAGAATACAAGGAAGAATATGAACCAAATATCGCTATATATCAAGATATTAGTGGTTTAATGCAAAATGAGGTGATTGAATTAAGTTTTGAGTATGAACGACAAGATAATACGCCAACAGAGAATAAATTAAGTGTTATCTGGAATGGTGAGGTTGTCTTCACTTCATCAAGTGATGATAAGTCAATAGCATGGCAACAACAACAAATTAAATTAACCGCAAATGCAGAAAATAATCGTCTTATTTTTACCATTCCAGGCTCTGATGGCTTGCAAGGAAATAATTACAGACTAAGAAATATTGTCGCTAAATCAGCTGTAGCAAATATAAACAAGCATATCTCAGATTCTGATGCGACAAAAAATGCCCTCGCTGACAAAAAGAAGGCAGATGCCAATCGTCAAAAACTAACTGATGAAAAACAACGCCTATTAGACCACATCTCTACCACACAGACTGAACTTGAATCGACCGATCACCTTGCACTGGAGAAAAACGGCCATAGAGAACGCGATGCCATTCTTGAAGAAGCTAATTCAGTAACACACAATTTGACCACAGTTGGTCAAACACTGGAAGTACTCAGCGAATATTCACAAGATGCCCCCCCCTCAGATCAACCATGGAGTGAGCCATTCGCGGAAGGAATTTTAAAGGATGTACAGAAGAGCTTAATTAATACTAAAAAAATTGTTTCAGTGCCTGTTAATAATATTAAAACTCAGTATGTTGCAAACCTTACAAAGGTGAAAAAATCGATAAAAAAATCGGAATATGGCGTTATTCAAAGTGAAGAACATTGTCAAGAAGTGCAACTCGATACTTCCAAAGCAAAAAATGATGCAGATAAAAGATACTCAGACGCGATAGATAAAAAAAATAGTGCTCAAATGGCAGAGAAAAAAGCATCAACCATGGTGGAAGATGCGAGATCACGAGGAGATACGGAGCAAAAAACAGCGACTAGCATATCGGATAAAGCACAAAAAGAAGCTAAATCTGTTCAACTGAAAGAAAGTGATAAACCTAATCGTCACAGGGCGCATGGTAGCGGTTTATCCGGAGAAGCGGCCTATGTAGAGGGGGCTGATGATAATCCATCCAGTTATATCAAACCAATATCAACTAAAAAAAATGATGGTCGTTTCAATAATAAACTGACAACATTTAATCAGGAATTACTTGATGATGCTCAGCAAGCCATTAATCGTTTAAGCATTAATGCTGGGATCCGACAAAAATCGGCAAACGTTCTTCCCTCTTTTACATCAGACCTTAATGGAGATGACGTAGCAACCTATCAACAACCTTCTCTTCGTTCAGGCAATCTTCAATATCACAAAATAGGAGCTATCGCGGTCAATCTTTCTGGATTAGGCGAAAGCCCCATTTTTGAAACGCTAAAACAAAAATTCAATGTAAAAATTAAGAATAGAAATACTTACTTTACTTTTATTTTGGAAAAAAATAGTGGTCGTATCCAAAAAAATATTTATTTGGATAACATCAATGATCCCACTCAGCAAAAAATAATAGAACACTTTATTTTAGCTAATTATTCAAATTTTGAAGCAATGCCTAATGAACTTCATTTAGAAAATGACAAAATTAAATCAAGTCATAACAACAAAGATAGGATACTTGCAGAATACGTAGAACATAAATGGCAAATGCTAACTGATTCAAAAGTCATGTCAGTTGATGAACTACATAAAGTTGCAAGTGTTAAAGGCAAAATACAAGGCGAAAGTTATAAATCAATCATTACAACTCTCTCGGAATACCATGAAAAAGAATCGAATACAAACTGCTTACCAATAGAGAAATTGAGAGTGCTAGCTCAGTTGCGAAACCAAATTGATGGTTACCTATTAGGACACCCCGACTCTGAACGCAATGATGGATTGAAACAGTTACAAACTCAAGTCAATACACGTTATAAACACGCATCGGCTTTAATACAAGATAGTCACACCATCAACGCTGATAGCAGCTTTAGTCGCTTATACGATTCACTTTCAAATGCCAATTTAAAAAGAAGTAAACACATTTATATTGATATTAACGGACACTTTGTCACTGAAGGAAAAAACAATCTGCAAGGGAAAAATAGACTAACCAGCGGAAAAGAAGTGATTGAGCGAGTAAAAAATGCCGTAGAAAAAGAATATGGCGCACCGATTGCCAATAAAGTCTTCAGTCAATTTGCAAATAATGAATTCGCTGAAAACGGCGAGGGTATTGATGTTTCAGGGTTAAAAAAAATTCACAGAGCTATTGAGCGGGAACTATCTCCTCATAGTGCAACCTTATATATCTGGAAACCAAGCAATCATAGTAATTTGGGACACGCCACACTACAAATAGGTCAAGGTCGCTTACTGTTAAACACAGAAGACGCACAAAATAATCATAAAGAAAACTACATCAGTTGGTGGCCTAACAAGGCGAAGTCATATTTTGATGTGATGGGAGTCCCCTCACAACCAAAAGAGTCGTTAGCATCGGATGTTGCAGCAGAAGAAAATGATGGCTTTGGTTTAAATTACAAATATAAAGAACTAAACAGATATGACCGACTCATGAATATTGCGAAAGGTGAAACGGTCACCACTGCAGATGATTTATCTCTTGCAGACGCAAAAAATATATTGACGATCCCAAATTATATAGAAAATTCAAAAATACCGCGAACAATTGGACAGCCTTTTATTGATGAATGGGTAATAACTCAGAAAAAACTCAACAACATCGCCACAAATTTTCTAGAAGCTGTACAAGGTAAATTTAGTGGAAATACCATAACTATAAATGGTGCCATGATACTATTGACAGAGCCCACGTTACTATCAAAAAGAAAAATCCCACTTTCTGTTGCACAGCCTTTTATTGAACAATGGGATAATATAAAAACACAACAAGAAGATATATCTATTCAATTATTAAAAGCGATGAAGACTTGGATACAAGAAGGTAAGGATCCAACGTTAACGAAAAAACGAATTGCTTTAGTAGAAAACGAATTTGCTGAGCAAAAACAAAAAAGTATTGACAGATTTAAAACCAGCTTACCTGATGAAGGACGAGTATTCCGTATTAATTTAGAGGGGTTAGACGTTGCTGCTATGCAAGCTGAATGGCAACGAATTAAAAATTCACCTAATGGTCGTTATCATTTATTAACCCAAAATTGTTCGAGTATCGTAGCGAAAATTTTAAAAGCGGGTGGCGCAGATGAACTGATTGGCTATAACTGGCAACCTAAATATAATATTTGGACACCAAATCAAATGTTCGCATTTGCTCAAGAGTTACAAGAAGCGCAAATGGCACGACAACAAAGTAGAATGATTCCACCTAACTTACACGCGTTGTCAGGTTCTGAAAATATCCGTCAAGAGCTAGAAAACACCTCCCCTCTTATTTCTGCTGAACAAAAGCTCAATATTGTTTTTAGTGAACAGGAAACGGGTTTTCTACTGACACAAGCATCAGATGAAACGAATGAAAAATTTATTTATATAAAAAATGGAGATAATCAAGAACAACAAAAAATAATGAGTAATTTTATACTCACTCATTATCGTGATTTTGACTCTATCCCTGAGCAACTTTATTTCTTAGATAATACAATCGTGTCACTCGATAAAAACCATTCACGAATATTATCAGAAAAAGTCGGTGAAAATTGGCAACCTGTTGCCTATTCGAATCTAATGACTGCTGATGAATTAACCTCCGCTGCAGAGGTGACAGGAAAAGCACGCGGTGAAAATTATAAAGCGATCATTCAATCGCTTAGAGATTATGAATTACAAAGTACAAATACAAACAACACACCAATAGATATATTTCAGCAACTATCCACATTACGTATACAAATTAATAGTTATCTGCTTAAACACCCTGATTCAAAACGTAACGAAGCATTGCAACAATTACGCGACCAAGTTGATATACGTTATAAACATGCTTCTATCTTATTAAGTAATAGCCAGCAAGTTGATTCAAATAATACTTTTAGTTATTTATATGAGATTTTTTCAAATGCTAACTTAAAAATCAACAAACATATTTATCTTGATGAAAACGGCAACTTTGTTACAAAAGGGAAAAATAATTTACAAAACCAAGACAAACTTATCAGTGGTAAAAATGCAATCACAAGCATTAAAAGATTGGTCGAAAAAGAGTATGGCAGTGAAATTACCAATCAGGTATTTAATCAATTTACAGAAAATGAATTTGCCCAAAATGGCCATGGTATTGACCTGTCAGGATTGAAAAAAATTCACCAAGCAATTGAACAACAAGTTTCACCAATCAGTTCTACACTATATATCTGGAAGCCCAGCAAACATAGTCGCTTGGGGCATGCTGCGCTACAAATAGGTTCTGGGCGCTTACAATTAGATAGCGATAGTGTGCAGGATAACCATGATAATAATTATGTCAGTTGGTGGCCTGCCGGGAGCAAATCGCTCGCAAACCCACTGAATATTACAACAGAAAAAAATCCTGATTTAAAATTACGCTGGTATGATTTAAGCCAACCAGTGAGTCGCTCAACAAATTTCATGACTTTACAAATTGATATTCAAGAAGAGGAAAAGACGAATTTCAAATTAAATAAAGATGAAGGGGAAAATGACAGACAGTTAAAAGAATTTAGAGATAAAACGAATCTTACCCGAGGTCTCGAAAATATTACACCTGAAATCGCAGGCTTACTGTTGAAAGCTCCTCATTTGATACCAGAAACACTTATCCCACCTGAAATTTCACACCCCTTTATTAAACAGTGGAAAAGCCCAAATAGTAATCTACTTGAAGTATCAACAAACTTTTCAATCGCAGTGAAAAACTGGCTAAAAGTCGCCTTTCCAACAGCGATGATTAACCAAACCTTTGCATTGGAAATCAAGAAAATTAAAGAAATTGAAGACCGAAAAACAGAAAATTTCAAAACAAGTGTCGCTGATGATACAAATGATGGCGTGGTGTTTCGCATTAATCTAGAGGGACTTGATGCCGCCGCCATGCAAAAAGAGTGGAAGCGCATTAATAGCCAGTCTGATCCTCGTTACCAATTATTAACCAAGAACTGTTCTAGTATTGTTGCTAGAATATTAAAAGCAGGCGGAGCAGATCAACTGATTGGTCATCATTGGAAACCTCGATTTGGCATATGGACACCAAATGAGTTGTATAAATTTTCTCAAAAGATACAGGAAGCACGCTTAGCCCAAATTGCGGTACAACAAGGCAAACCTATACATTCTAATTTACAAGCATTATCAGACCACAATAAAGTGGCTATTGATAATGACGGTACATCACCAAACGAGAGAAAAAATCTTAGCCCATTAACACGTTTTTTTAATGATCATTTTTTCGGCAGCTATGAACGTCGTAGAGACATGACAACGGTGATGAGAATAAAAAATGAAGAAAAAATAACATTAAAAGGGGATGCAGGCCGTCTTACAGGATCATATTACAGAGGAAACGACAATATTCCAGAAGCTACCGATAAGAAAGTAGTACTATTTTTACATGGTTCAAATTCCCCTACCGAAAAACAATCCTCTAGTTTTTATCATTATTATAACCAACAAGGCATCGATATGTTAGCGATTAACATGAGAGGGTTTGGCGAAAGCGATGGCTCGCCAACAGAGCAAGGAATGTATGCTGATGCACAAACCATGTTCCGTTATCTCGTTAATGATAAAGGTATCGATCCTAAAAATATTATTATTCATGGTTATTCCATGGGGGCACCAATTGCGGCTAAATTAGCCAGCGATATTTCAGCTAACGGTCAGCATATAGCTGGGCTATTCTTAGATAGACCAATGCCAAGTATGTCAAAAGCAATTGAATCTTATGATGAATATAGCCTTAAGAAATTGACTGGACAACTCGCAAAAAAAATCAATGGCCAATTCTCCGTAGAAAAAAATCTACAGGGTTTCTCAAAAGATATCCCCATTATATTGCTCACTGACTGTGGCGAGCTGGGCATTGGTGGTGAAAAAATGCGCACTAAATTACTTGATAAAGGATATCTAGTTAAAGGAGAAAGAACCGATGTTTCTCATTTAGAGAGCCTTAAGTTGATGAATCAATACGGTAAACAAATAATATCAAGTTTACTATCCCCAGAGTATGTAAATAACACCAATCACAGAAATGCGTTAGATTCGATACAAAACCCGATAAAAAAGAATAAGGTGACTGATTGGGGGATGGTATATGTAAAACCCAATGATAATGGGGGTGATAGTCGTTTTGATAGCCAGATTATTATCCAAACAGAGGATGATCCGATAGTCGCTCAAGCAGCTTCGGCACTTGCCGCTAAACATGCCAAAAATAGTATCGTGGTACAATTGGATGCCGATGGTCATTACCGCGTAGCTTATGGCGACCCAGCACAACTTTCAGGTAAAATACGTTGGCAGCTTGTTGGCCATGGTCGTGAAACAACCGAAAATAATCATTTACGCCTTAGCAACTACAATGCTGATGAGCTTTCCAATCAATTGGTTAAATTCAATACCGTATTCAGCAAAGAAAATAATATCAATACAACTCCTGAACATATCAGTATTGTCGGTTGTTCATTAATAAGTAATGACAAGCAGGCAGGATTTGCCCACCAGTTTATCAATGCATTAGATCAACAAGGCATTCGTAGTAGCGTTTCTGCTCGAGTAACAGAGGTCGCCGTTGATAGCAATGGTCACAAATACACCAAAGATAACAACGGAGAGTGGGTAGCCAAACAAACCCAAAACAAGGTAGTGTTAGATTGGAATAAAGAAGGCAAAATCACGACTGAATTTGAGCAAATACATAATGGTGTTGCTGAAGGTGATATTGATTTGACTAAAGTAGGTGCTTCAGCTGACAACAAAGTACGTGGCGCAATTGCAGATAATAATGAAGTCTTTACCGCCCCCAAAAAAGGTAAAAAATCAACCAAACAAAGCTCATCAGGAAGTGATAATTCATCACTAAGCTATTCTGGCAATATCCAAGTCAGTGTGGGTGACGGCGAGTTTACAACGGTTAATTGGGGAACCTCTAATCTTGGGATCAAAGTAGGTACTGGCGGATTTAAATCACTGGTTTTCGGTGATAACAATGTGATGGTACACGTTGGTAATGGTGATAGTAAACATAGTGTTGATATTGCTGGCTATCAAGCTTTCGAAGGTATGCAATTATTTGTTGGTACACGTAACGTCAGCTTTAATCTGGGGCGTAGTAATGATCTTATTGTGATGTTAGAAAAATCAATTCCAACCCCTCCACTGATCAACCCTTTTGATGGTGCTGCTAGAATCACCAAAGTTCTAGAGTCAATCGCATGCTCAGGTGAAAATAATGATAATGATTGGTTGTCGGTACAAAACGATCAGTGGACACTCGCTGGCGCTAAAAAATTTGCCATAGATATGTCAGGAATAGACCAAACGAGCAATGTTGACTATAAAACACTGACTGATCTGAATTCACAGAATAAGCGTAGTAGCCGTGGATTAAAGAGTGATCTAGAAGCCACACTAAACAAAAAATATAACCAGTGGTTAGGTGGTAGTGGCAATAACAACGAGATGGGAAAAATCAGCCGAGCTGAGCAACTTCGTCAACTAGATAGTAAAATCGCTTTTAATTTCGCCATTGGTGGTCAAGGTGCTGATATTCAAGTTACTGCCGGGAATTGGAACTTGATGTTTGGTGATAATATCCAGTCTATTATAGACACTAATCTTGGCTCATTATTTGGCTTAATGACGCAGCAATTTACAGCAACTGGTATGGTGGAAACCACCTTTACTTATACCCCCCAAAACTTACCAACTAAGTTAAAAAATAAATTGCTAGGTCGGTTAGCCAGCGTGAGTTCAGACACGACTCTGGGGGATATTTTTGGAGTAGACTCTACCACAGATGGAAAAATAATCTCTCGTAATGGTGAGCCCATTGATGTTGTCGCTATTTTGAAAGATATGCTCGCTGTAGTGACTGAGTTTGGAGGTGAAAAACTGTCCGCATTTACTGATCCGACTAAATTATTAGATAACCTCCAATCATCTATTAATCTGGGCAAGGATGGTATTATTTCATTTGCTGAAAGCCATGGTTTAAAAGAAAAAGCGACAGAAGATCAACAAAATGAATCTGAAGTTTCAATTAATGCCCAAACACCAATAACAACGAGTCAAACTGAAAATAGCAAGATCACAGAGGAAAATGATCGCCCTTTCGGCTTCAATTCGCTAAATATCCCCAATCTATTTGCCACAATCTTTAATAAAGATAAACAAACAGATATGCGTGATCTCGCAGAAAACCTCAAAGAAAATTTAGCAGCTGATGTACTGAACATGGAGAAGAAAACGCTCGATTTCTTGCGTAATAGTGGTCATTTAAAAGGCGATGGTGACATACATGTCTCTCTTGGCAACTATAATTTCAACTGGGGGGGAGATGGTAATGATCTCGGCGCTTACCTAGGAGATAATAATAATTTTTGGGGTGGGCGTGGTTCAGATACTTTCTATGCAACGGGGATCTCAAATATTTTTACTGGGGGTTACGGAAATGATCTCGGCGTCTTGATGGGGCGCTCAAACATGATGTTTGGAGGCGATGGAGATGACACTGCTATTATCGCCGGTCGGATCAATAATGTCTATTTAGGTGACGGACTCGATAAAGCATTTGTCTTTGGGGAAGGCGGTGAAATTCACACTAATGCAGGTAATGACTATGTTGTCACTACCGGTAACTACAATCGCATTTTCAGTGGTAGTGAACAAGATTTTGTTGTCACAATTGGTAACCACAACCAAATATCCTTAGAAGAAGGCAATGATTTTGCCAAAATTTTTGGTAACTACAATAGGTTGAATGGAGGGGGCGGTGATGACGAAATTCAACTAATGGGTTATCACGCCGTAGTTGATGGAGGCGATGGAAATGATCAACTAATTGCAGCTTCATTCTCGAAATTTAGCCTTCTTAATGGTAATACAGGTAATGATATTATCATATTAGGTGGATATCAGAACCACTTCAAAGGTGGAAACGGTATCGATAGCTTCCTGATTAATAATAATGTGATTGATTGTTATATAGACGATATTAGCCAAGAAGATAATATTGTACTTGGAGATATTGATTGGAATAAATTATGGTTTGAACGCAGTGGCTATGATTTAAAGATCTCACATATTCGCTTCCCACAAAATACAGGGGAACAAGCCACATTTGAGCGCATTGGCTCAACTACTTTTACTGATTATTTCAATGGTAATCAGGCAAAAATCGTTATCGCAATGACTGATAAAGATCACTCTGATCAGCGCGAATATACGGCTTTATCAAGCAATGCACTCGCTATTCAAATTCAGGCCATGAGTACATTTCCTATGAAGGCAGGCGCATCCGGATTTTTCGATAATATAAGTGATGAGGCTAAACAAATGATAGCCGTAGCTTGGACAGATACAATTTCAGGAAAAGGCATATTAGTGTAGTTTAGCCATACTCTATAACTATAATAAATCCTCTCCGTTGGATGTGAACT