Homologs in group_1307

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6 homologs were identified in 6 genomes with OrthoFinder.
The following table displays the locus tag of each homolog, the organism to which it belongs, the gene name and product.

Locus tag Identity Source Gene Product
FBDBKF_08005 FBDBKF_08005 63.5 Morganella morganii S1 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
EHELCC_13835 EHELCC_13835 63.5 Morganella morganii S2 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
NLDBIP_14280 NLDBIP_14280 63.5 Morganella morganii S4 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
LHKJJB_08570 LHKJJB_08570 63.5 Morganella morganii S3 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
HKOGLL_08120 HKOGLL_08120 63.5 Morganella morganii S5 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
F4V73_RS12980 F4V73_RS12980 65.4 Morganella psychrotolerans folK 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase

Distribution of the homologs in the orthogroup group_1307

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Number of homologs in each genome (first column) and amino-acid identity of the closest homolog (second column).

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Phylogeny of the RefSeq best hits of group_1307

Swissprot accession Eval Score ID (%) N gaps Alignment length Annot score Gene Description Organism
P26281 1.66e-63 195 62 2 157 1 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Escherichia coli (strain K12)
P43777 8.06e-49 157 51 1 137 1 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Q9HV71 1.8e-48 157 54 2 159 3 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Q8P151 1.3e-34 122 40 1 155 3 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Streptococcus pyogenes serotype M18 (strain MGAS8232)
P0DB11 2.45e-34 121 40 1 155 3 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Streptococcus pyogenes serotype M3 (strain SSI-1)
P0DB10 2.45e-34 121 40 1 155 3 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
P0C0G2 2.75e-34 121 40 1 155 3 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Streptococcus pyogenes
P0C0G3 2.75e-34 121 40 1 155 3 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Streptococcus pyogenes serotype M1
Q5XCA6 2.33e-33 119 40 1 155 3 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
P71512 8.37e-32 114 38 2 158 3 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)
P29252 4.81e-30 110 44 1 133 3 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Bacillus subtilis (strain 168)
P72736 5.37e-28 105 37 2 148 3 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Q4LB35 6.6e-28 111 35 1 164 1 fol1 Folic acid synthesis protein fol1 Schizosaccharomyces pombe (strain 972 / ATCC 24843)
O87790 2.52e-24 94 51 2 118 3 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (Fragment) Pseudomonas putida
Q8GJP4 2.87e-24 99 38 1 132 3 folKE Bifunctional protein FolKE Lactococcus lactis subsp. cremoris (strain MG1363)
O66550 2.58e-23 92 35 2 137 3 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Aquifex aeolicus (strain VF5)
P29251 4.16e-22 95 37 2 150 1 fol1 Folic acid synthesis protein fol1 Pneumocystis carinii
Q1ENB6 6.34e-20 88 38 2 132 1 CytHPPK/DHPS Folate synthesis bifunctional protein Arabidopsis thaliana
Q9SZV3 8.19e-20 88 39 2 133 2 MitHPPK/DHPS Folate synthesis bifunctional protein, mitochondrial Arabidopsis thaliana
P59657 2.74e-19 85 32 3 149 1 sulD Bifunctional folate synthesis protein Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
P22291 2.83e-19 85 32 3 149 1 sulD Bifunctional folate synthesis protein Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
O04862 3.7e-19 86 38 2 134 1 MitHPPK/DHPS Folate synthesis bifunctional protein, mitochondrial Pisum sativum
Q9ZM35 3.42e-16 74 32 0 131 3 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Helicobacter pylori (strain J99 / ATCC 700824)
Q54YD9 4.31e-16 77 32 2 137 3 fol1 Folic acid synthesis protein FOL1 Dictyostelium discoideum
O25680 7.43e-16 73 32 0 131 3 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Helicobacter pylori (strain ATCC 700392 / 26695)
Q9CGE3 7.58e-16 76 36 1 132 3 folKE Bifunctional protein FolKE Lactococcus lactis subsp. lactis (strain IL1403)
P53848 1.01e-14 73 32 4 155 1 FOL1 Folic acid synthesis protein FOL1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P0C936 3.11e-14 68 34 3 136 3 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
B2RI92 3.11e-14 68 34 3 136 3 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)
P82602 2.11e-13 70 30 5 163 3 folKP Folate synthesis bifunctional protein Chlamydia muridarum (strain MoPn / Nigg)
P9WNC7 3.91e-13 67 33 4 143 1 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WNC6 3.91e-13 67 33 4 143 3 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
P64144 3.91e-13 67 33 4 143 3 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
O84619 3.39e-12 66 27 5 163 3 folKP Folate synthesis bifunctional protein Chlamydia trachomatis serovar D (strain ATCC VR-885 / DSM 19411 / UW-3/Cx)
Q821E2 1.23e-11 65 31 5 148 3 folKP Folate synthesis bifunctional protein Chlamydia caviae (strain ATCC VR-813 / DSM 19441 / 03DC25 / GPIC)
O69528 7.18e-11 61 32 7 161 3 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Mycobacterium leprae (strain TN)
Q9PJ54 1.26e-10 59 28 1 126 3 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Q9Z7E8 8.67e-08 53 29 3 147 3 folKP Folate synthesis bifunctional protein Chlamydia pneumoniae

  • Number of RefSeq hits:

General

Source Proteus mirabilis HI4320
Locus tag PMI_RS00950
Feature type CDS
Gene folK
Product 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase
Location 233537 - 234034 (strand: -1)
Length 498 (nucleotides) / 165 (amino acids)

Contig

Accession NC_010554
Length 4063606 nucleotides
Topology circular
Plasmid False

Orthology

Orthogroup group_1307
Orthogroup size 7
N. genomes 7

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Genomic region

Domains

PF01288 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)

COG entry Annotation(s)

ID Function(s) descr. Function(s) cat. Description
COG0801 Coenzyme transport and metabolism (H) H 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (folate biosynthesis)

Kegg Ortholog Annotation(s)

KO Description Pathways Modules
K00950 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3] Folate biosynthesis
Metabolic pathways
Biosynthesis of cofactors		 Tetrahydrofolate biosynthesis, GTP => THF

Protein Sequence

MSKQQQRVYIILGSNLNSPEQQVKSAIKAISEIPNTTLIAQSPWYRTRPMGPQDQPDYLNMAVAVDTTLAPEELLDHTQAIELAHGRERKAGNRWGPRTLDLDIMLFGDQVIQTERLTVPHYGLKVREFMLYPLADLAPELCFPDDGERLADRLALVPKNGMEKW

Flanking regions ( +/- flanking 50bp)

TCCTCGTCACCCTAATGCAAAAAATAATGCACCAAGACAAGAGAACAAACATGAGTAAGCAACAACAGCGTGTGTATATTATTCTGGGCAGTAATTTAAACTCACCAGAACAGCAAGTAAAATCGGCGATAAAAGCGATTAGTGAAATCCCTAATACTACACTGATTGCCCAATCACCTTGGTATCGCACACGCCCTATGGGACCTCAAGATCAACCCGATTATCTCAATATGGCTGTCGCCGTTGATACTACTTTAGCCCCAGAAGAGTTGCTCGACCATACACAAGCAATTGAACTTGCCCATGGTCGTGAAAGAAAAGCAGGTAACCGTTGGGGACCTCGTACCCTTGATTTAGATATCATGTTATTTGGTGATCAAGTTATACAGACCGAACGTTTAACTGTGCCTCATTATGGACTTAAGGTGCGTGAATTTATGCTTTATCCATTGGCGGATTTAGCACCTGAACTTTGTTTCCCTGATGACGGAGAACGATTAGCAGACAGATTAGCGCTCGTACCTAAAAATGGTATGGAAAAGTGGTGATACCACATAATAAGCGTGTTTGATGTTAATGGTTGATGCTGTTGACTGAC