Homologs in group_3667

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3 homologs were identified in 3 genomes with OrthoFinder.
The following table displays the locus tag of each homolog, the organism to which it belongs, the gene name and product.

Locus tag Identity Source Gene Product
FBDBKF_20150 FBDBKF_20150 100.0 Morganella morganii S1 blaNDM-1 subclass B1 metallo-beta-lactamase NDM-1
NLDBIP_19595 NLDBIP_19595 100.0 Morganella morganii S4 blaNDM-1 subclass B1 metallo-beta-lactamase NDM-1
LHKJJB_19560 LHKJJB_19560 100.0 Morganella morganii S3 blaNDM-1 subclass B1 metallo-beta-lactamase NDM-1

Distribution of the homologs in the orthogroup group_3667

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Number of homologs in each genome (first column) and amino-acid identity of the closest homolog (second column).

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Phylogeny of the RefSeq best hits of group_3667

Swissprot accession Eval Score ID (%) N gaps Alignment length Annot score Gene Description Organism
C7C422 0.0 555 100 0 270 1 blaNDM-1 Metallo-beta-lactamase type 2 Klebsiella pneumoniae
Q7WYA8 4.8e-38 137 34 3 221 1 bla-imp13 Metallo-beta-lactamase type 2 Pseudomonas aeruginosa
P52699 2.16e-37 135 33 4 228 1 None Metallo-beta-lactamase type 2 Serratia marcescens
P25910 4.02e-37 134 32 2 225 1 ccrA Metallo-beta-lactamase type 2 Bacteroides fragilis
P04190 4.48e-33 124 33 4 212 1 blm Metallo-beta-lactamase type 2 Bacillus cereus
P14488 5.24e-33 124 33 4 218 1 None Metallo-beta-lactamase type 2 Bacillus cereus
P10425 4.01e-32 122 33 4 206 1 None Metallo-beta-lactamase type 2 Bacillus sp. (strain 170)
Q9KJA9 6.68e-27 107 27 4 226 3 blaB5 Metallo-beta-lactamase type 2 Elizabethkingia meningoseptica
Q9KJB0 1.05e-26 107 27 4 226 3 blaB6 Metallo-beta-lactamase type 2 Elizabethkingia meningoseptica
Q9KJA7 1.19e-26 107 27 4 226 3 blaB8 Metallo-beta-lactamase type 2 Elizabethkingia meningoseptica
Q9KJA8 1.8e-26 106 27 4 226 3 blaB7 Metallo-beta-lactamase type 2 Elizabethkingia meningoseptica
O08498 2.42e-26 106 27 4 231 1 blaB1 Metallo-beta-lactamase type 2 Elizabethkingia meningoseptica
Q9K303 3.11e-26 106 28 4 223 3 blaB3 Metallo-beta-lactamase type 2 Elizabethkingia meningoseptica
Q9RB01 6.85e-25 102 26 4 231 3 blaB2 Metallo-beta-lactamase type 2 Elizabethkingia meningoseptica
Q9XBN7 2.15e-24 101 26 5 253 3 blaB4 Metallo-beta-lactamase type 2 Elizabethkingia meningoseptica
P26918 1.42e-09 60 24 4 195 1 cphA Metallo-beta-lactamase type 2 Aeromonas hydrophila
Q5XGR8 0.00064 43 27 8 150 2 lactb2 Endoribonuclease LACTB2 Xenopus laevis

  • Number of RefSeq hits:

General

Source Morganella morganii S5
Locus tag HKOGLL_19475
Feature type CDS
Gene blaNDM-1
Product subclass B1 metallo-beta-lactamase NDM-1
Location 4559 - 5371 (strand: 1)
Length 813 (nucleotides) / 270 (amino acids)

Contig

Accession ZDB_716
Length 7614 nucleotides
Topology linear
Plasmid False

Orthology

Orthogroup group_3667
Orthogroup size 4
N. genomes 4

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Genomic region

Domains

PF00753 Metallo-beta-lactamase superfamily

COG entry Annotation(s)

ID Function(s) descr. Function(s) cat. Description
COG0491 General function prediction only (R) R Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II

Kegg Ortholog Annotation(s)

KO Description Pathways Modules
K18780 metallo-beta-lactamase class B NDM [EC:3.5.2.6] beta-Lactam resistance Carbapenem resistance

AMR gene Annotation(s)

Gene Description Scope Type Class Subclass HMM
blaNDM-1 subclass B1 metallo-beta-lactamase NDM-1 core AMR BETA-LACTAM CARBAPENEM NF000259 

Protein Sequence

MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR

Flanking regions ( +/- flanking 50bp)

CTAGGCCTCGCATTTGCGGGGTTTTTAATGCTGAATAAAAGGAAAACTTGATGGAATTGCCCAATATTATGCACCCGGTCGCGAAGCTGAGCACCGCATTAGCCGCTGCATTGATGCTGAGCGGGTGCATGCCCGGTGAAATCCGCCCGACGATTGGCCAGCAAATGGAAACTGGCGACCAACGGTTTGGCGATCTGGTTTTCCGCCAGCTCGCACCGAATGTCTGGCAGCACACTTCCTATCTCGACATGCCGGGTTTCGGGGCAGTCGCTTCCAACGGTTTGATCGTCAGGGATGGCGGCCGCGTGCTGGTGGTCGATACCGCCTGGACCGATGACCAGACCGCCCAGATCCTCAACTGGATCAAGCAGGAGATCAACCTGCCGGTCGCGCTGGCGGTGGTGACTCACGCGCATCAGGACAAGATGGGCGGTATGGACGCGCTGCATGCGGCGGGGATTGCGACTTATGCCAATGCGTTGTCGAACCAGCTTGCCCCGCAAGAGGGGATGGTTGCGGCGCAACACAGCCTGACTTTCGCCGCCAATGGCTGGGTCGAACCAGCAACCGCGCCCAACTTTGGCCCGCTCAAGGTATTTTACCCCGGCCCCGGCCACACCAGTGACAATATCACCGTTGGGATCGACGGCACCGACATCGCTTTTGGTGGCTGCCTGATCAAGGACAGCAAGGCCAAGTCGCTCGGCAATCTCGGTGATGCCGACACTGAGCACTACGCCGCGTCAGCGCGCGCGTTTGGTGCGGCGTTCCCCAAGGCCAGCATGATCGTGATGAGCCATTCCGCCCCCGATAGCCGCGCCGCAATCACTCATACGGCCCGCATGGCCGACAAGCTGCGCTGAGCCATGGCTGACCACGTCACCCCCAATCTGCCATCGCGCGATTTCGATGT