Homologs in group_52

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13 homologs were identified in 7 genomes with OrthoFinder.
The following table displays the locus tag of each homolog, the organism to which it belongs, the gene name and product.

Locus tag Identity Source Gene Product
FBDBKF_11085 FBDBKF_11085 99.9 Morganella morganii S1 - TonB-dependent receptor
FBDBKF_14795 FBDBKF_14795 39.9 Morganella morganii S1 fepA ligand-gated channel protein
EHELCC_15600 EHELCC_15600 39.9 Morganella morganii S2 fepA ligand-gated channel protein
NLDBIP_05460 NLDBIP_05460 99.9 Morganella morganii S4 - TonB-dependent receptor
NLDBIP_16130 NLDBIP_16130 39.9 Morganella morganii S4 fepA ligand-gated channel protein
LHKJJB_02340 LHKJJB_02340 99.9 Morganella morganii S3 - TonB-dependent receptor
LHKJJB_15710 LHKJJB_15710 39.9 Morganella morganii S3 fepA ligand-gated channel protein
HKOGLL_14830 HKOGLL_14830 39.9 Morganella morganii S5 fepA ligand-gated channel protein
HKOGLL_15720 HKOGLL_15720 99.9 Morganella morganii S5 - TonB-dependent receptor
F4V73_RS07595 F4V73_RS07595 39.7 Morganella psychrotolerans - ligand-gated channel protein
F4V73_RS08185 F4V73_RS08185 87.5 Morganella psychrotolerans - TonB-dependent receptor
PMI_RS04135 PMI_RS04135 41.1 Proteus mirabilis HI4320 - ligand-gated channel protein
PMI_RS09585 PMI_RS09585 62.4 Proteus mirabilis HI4320 - IreA family TonB-dependent siderophore receptor

Distribution of the homologs in the orthogroup group_52

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Number of homologs in each genome (first column) and amino-acid identity of the closest homolog (second column).

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Phylogeny of the RefSeq best hits of group_52

Swissprot accession Eval Score ID (%) N gaps Alignment length Annot score Gene Description Organism
P0C6R0 2.5e-135 415 37 15 681 3 irgA Iron-regulated outer membrane virulence protein Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
A5F9G0 2.05e-134 412 36 14 681 3 irgA Iron-regulated outer membrane virulence protein Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
P17315 2.56e-129 400 38 25 713 1 cirA Colicin I receptor Escherichia coli (strain K12)
P05825 3.29e-68 240 28 21 704 1 fepA Ferrienterobactin receptor Escherichia coli (strain K12)
D0C8V9 1.33e-63 228 28 25 778 1 pirA Probable TonB-dependent siderophore receptor PirA Acinetobacter baumannii (strain ATCC 19606 / DSM 30007 / JCM 6841 / CCUG 19606 / CIP 70.34 / NBRC 109757 / NCIMB 12457 / NCTC 12156 / 81)
Q9I527 3.01e-61 221 28 20 689 1 pirA Ferric enterobactin receptor PirA Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Q05098 1.23e-57 211 27 20 730 1 pfeA Ferric enterobactin receptor Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Q6LLU3 9.21e-26 115 24 24 592 3 btuB Vitamin B12 transporter BtuB Photobacterium profundum (strain SS9)
Q8DD41 6.41e-22 103 41 4 158 3 btuB Vitamin B12 transporter BtuB Vibrio vulnificus (strain CMCP6)
Q7MQ42 1.06e-20 100 40 4 159 3 btuB Vitamin B12 transporter BtuB Vibrio vulnificus (strain YJ016)
O52903 3.25e-19 95 37 3 154 3 btuB Vitamin B12 transporter BtuB Citrobacter freundii
O52903 0.00078 46 23 10 268 3 btuB Vitamin B12 transporter BtuB Citrobacter freundii
Q8X714 3.64e-18 92 36 4 153 3 btuB Vitamin B12 transporter BtuB Escherichia coli O157:H7
A4WG45 1.19e-17 90 32 3 181 3 btuB Vitamin B12 transporter BtuB Enterobacter sp. (strain 638)
A4WG45 0.000221 48 22 10 279 3 btuB Vitamin B12 transporter BtuB Enterobacter sp. (strain 638)
P37409 1.6e-17 90 35 3 154 3 btuB Vitamin B12 transporter BtuB Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Q5PK67 1.65e-17 90 35 3 154 3 btuB Vitamin B12 transporter BtuB Salmonella paratyphi A (strain ATCC 9150 / SARB42)
Q57H87 1.65e-17 90 35 3 154 3 btuB Vitamin B12 transporter BtuB Salmonella choleraesuis (strain SC-B67)
A7ML93 2.46e-17 89 34 3 179 3 btuB Vitamin B12 transporter BtuB Cronobacter sakazakii (strain ATCC BAA-894)
A7ZUI6 2.56e-17 89 35 3 153 3 btuB Vitamin B12 transporter BtuB Escherichia coli O139:H28 (strain E24377A / ETEC)
A8A774 2.58e-17 89 35 3 153 3 btuB Vitamin B12 transporter BtuB Escherichia coli O9:H4 (strain HS)
Q3YV10 2.7e-17 89 35 3 153 3 btuB Vitamin B12 transporter BtuB Shigella sonnei (strain Ss046)
P06129 2.7e-17 89 35 3 153 1 btuB Vitamin B12 transporter BtuB Escherichia coli (strain K12)
Q0TA90 2.7e-17 89 35 3 153 3 btuB Vitamin B12 transporter BtuB Escherichia coli O6:K15:H31 (strain 536 / UPEC)
Q1R3U1 2.75e-17 89 35 3 153 3 btuB Vitamin B12 transporter BtuB Escherichia coli (strain UTI89 / UPEC)
Q1R3U1 0.001 46 22 10 277 3 btuB Vitamin B12 transporter BtuB Escherichia coli (strain UTI89 / UPEC)
A1AIE8 2.75e-17 89 35 3 153 3 btuB Vitamin B12 transporter BtuB Escherichia coli O1:K1 / APEC
A1AIE8 0.001 46 22 10 277 3 btuB Vitamin B12 transporter BtuB Escherichia coli O1:K1 / APEC
Q8Z314 2.9e-17 89 35 3 154 3 btuB Vitamin B12 transporter BtuB Salmonella typhi
Q8CVJ0 2.95e-17 89 35 3 153 3 btuB Vitamin B12 transporter BtuB Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Q0SY25 3.8e-17 89 36 3 153 3 btuB Vitamin B12 transporter BtuB Shigella flexneri serotype 5b (strain 8401)
Q83IS4 3.9e-17 89 36 3 153 3 btuB Vitamin B12 transporter BtuB Shigella flexneri
Q93SE0 7.64e-17 88 34 2 153 3 btuB Vitamin B12 transporter BtuB Escherichia coli
Q93SE0 8.61e-08 59 23 10 277 3 btuB Vitamin B12 transporter BtuB Escherichia coli
Q32AE6 1.94e-16 86 35 3 153 3 btuB Vitamin B12 transporter BtuB Shigella dysenteriae serotype 1 (strain Sd197)
Q7MYE3 4.09e-16 85 36 5 157 3 btuB Vitamin B12 transporter BtuB Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Q7MYE3 1.22e-06 55 24 11 288 3 btuB Vitamin B12 transporter BtuB Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
C3LPZ6 6.27e-16 85 36 3 133 3 btuB Vitamin B12 transporter BtuB Vibrio cholerae serotype O1 (strain M66-2)
C3LPZ6 2.68e-05 51 27 12 216 3 btuB Vitamin B12 transporter BtuB Vibrio cholerae serotype O1 (strain M66-2)
Q9KVI9 6.27e-16 85 36 3 133 3 btuB Vitamin B12 transporter BtuB Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Q9KVI9 2.68e-05 51 27 12 216 3 btuB Vitamin B12 transporter BtuB Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
A5F4P6 6.27e-16 85 36 3 133 3 btuB Vitamin B12 transporter BtuB Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
A5F4P6 2.68e-05 51 27 12 216 3 btuB Vitamin B12 transporter BtuB Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Q6CZB5 8.36e-16 84 34 3 153 3 btuB Vitamin B12 transporter BtuB Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)
Q6CZB5 5.21e-11 69 23 13 358 3 btuB Vitamin B12 transporter BtuB Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)
A4TRG0 1.61e-15 84 31 4 160 3 btuB Vitamin B12 transporter BtuB Yersinia pestis (strain Pestoides F)
A4TRG0 1.05e-08 62 22 13 338 3 btuB Vitamin B12 transporter BtuB Yersinia pestis (strain Pestoides F)
Q1CNP0 1.61e-15 84 31 4 160 3 btuB Vitamin B12 transporter BtuB Yersinia pestis bv. Antiqua (strain Nepal516)
Q1CNP0 1.05e-08 62 22 13 338 3 btuB Vitamin B12 transporter BtuB Yersinia pestis bv. Antiqua (strain Nepal516)
Q8ZAA1 1.61e-15 84 31 4 160 3 btuB Vitamin B12 transporter BtuB Yersinia pestis
Q8ZAA1 1.05e-08 62 22 13 338 3 btuB Vitamin B12 transporter BtuB Yersinia pestis
Q1CBU1 1.61e-15 84 31 4 160 3 btuB Vitamin B12 transporter BtuB Yersinia pestis bv. Antiqua (strain Antiqua)
Q1CBU1 1.05e-08 62 22 13 338 3 btuB Vitamin B12 transporter BtuB Yersinia pestis bv. Antiqua (strain Antiqua)
Q66G57 2.76e-15 83 32 5 161 3 btuB Vitamin B12 transporter BtuB Yersinia pseudotuberculosis serotype I (strain IP32953)
Q66G57 7.32e-08 59 24 11 289 3 btuB Vitamin B12 transporter BtuB Yersinia pseudotuberculosis serotype I (strain IP32953)
A7FD14 2.76e-15 83 32 5 161 3 btuB Vitamin B12 transporter BtuB Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
A7FD14 7.32e-08 59 24 11 289 3 btuB Vitamin B12 transporter BtuB Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
P31499 4.36e-15 82 33 4 157 2 hemR Hemin receptor Yersinia enterocolitica
Q87KN9 4.53e-15 82 31 11 260 3 btuB Vitamin B12 transporter BtuB Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
A7MXY8 2.36e-14 80 30 8 227 3 btuB Vitamin B12 transporter BtuB Vibrio campbellii (strain ATCC BAA-1116)
Q56989 8.11e-14 78 35 3 139 3 hmuR Hemin receptor Yersinia pestis
P44600 6.77e-11 69 35 7 165 1 hxuC Heme/hemopexin utilization protein C Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Q4QNS6 3.62e-10 67 34 8 164 3 hxuC Heme/hemopexin utilization protein C Haemophilus influenzae (strain 86-028NP)
Q4QNS6 0.000432 47 26 8 195 3 hxuC Heme/hemopexin utilization protein C Haemophilus influenzae (strain 86-028NP)
P45357 5.89e-10 66 32 7 175 3 hxuC Heme/hemopexin utilization protein C Haemophilus influenzae
Q8YZR0 4.55e-09 63 34 8 163 1 schT Schizokinen transporter SchT Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Q8YQ14 1.23e-08 62 26 8 193 1 iacT Iron and copper transporter IacT Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
P0CL48 1.75e-07 58 27 7 205 3 foxA Ferrioxamine B receptor Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
E1W8M5 1.76e-07 58 27 7 205 3 foxA Ferrioxamine B receptor Salmonella typhimurium (strain SL1344)
P76356 2.16e-07 53 36 2 87 3 yoeA Protein YoeA Escherichia coli (strain K12)
D0CAH3 4.06e-07 57 27 6 158 1 piuA Probable TonB-dependent siderophore receptor PiuA Acinetobacter baumannii (strain ATCC 19606 / DSM 30007 / JCM 6841 / CCUG 19606 / CIP 70.34 / NBRC 109757 / NCIMB 12457 / NCTC 12156 / 81)
D0CAH3 5.15e-05 50 23 8 254 1 piuA Probable TonB-dependent siderophore receptor PiuA Acinetobacter baumannii (strain ATCC 19606 / DSM 30007 / JCM 6841 / CCUG 19606 / CIP 70.34 / NBRC 109757 / NCIMB 12457 / NCTC 12156 / 81)
P06971 5e-07 57 27 3 174 1 fhuA Ferrichrome outer membrane transporter/phage receptor Escherichia coli (strain K12)
P46359 1.63e-06 55 29 11 204 1 fyuA Pesticin receptor Yersinia pestis
Q7VNU1 1.82e-06 55 22 34 616 2 tdhA TonB-dependent heme receptor A Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Q8X7W7 2.66e-06 54 30 6 169 3 fiu Catecholate siderophore receptor Fiu Escherichia coli O157:H7
P75780 2.89e-06 54 30 6 169 1 fiu Catecholate siderophore receptor Fiu Escherichia coli (strain K12)
Q1REC0 3.07e-06 54 30 6 169 3 fiu Catecholate siderophore receptor Fiu Escherichia coli (strain UTI89 / UPEC)
Q8CW90 3.15e-06 54 30 6 169 3 fiu Catecholate siderophore receptor Fiu Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
P76115 8.26e-06 52 25 9 258 1 pqqU Pyrroloquinoline quinone transporter Escherichia coli (strain K12)
P76115 4e-05 50 27 9 178 1 pqqU Pyrroloquinoline quinone transporter Escherichia coli (strain K12)
P0C2M9 8.78e-06 52 29 11 204 2 fyuA Pesticin receptor Yersinia enterocolitica
A1JTG3 9.08e-06 52 29 11 204 3 fyuA Pesticin receptor Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
P48632 4.4e-05 50 27 4 141 1 fpvA Ferripyoverdine receptor Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
P44795 7.67e-05 50 25 7 176 1 HI_0635 Probable hemoglobin and hemoglobin-haptoglobin-binding protein 1 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Q01674 0.00012 49 29 8 176 3 foxA Ferrioxamine receptor Yersinia enterocolitica
Q01674 0.000735 46 27 7 190 3 foxA Ferrioxamine receptor Yersinia enterocolitica
Q9L9Z9 0.000146 48 21 29 658 1 vuuA Ferric vulnibactin receptor VuuA Vibrio vulnificus
P81549 0.000216 48 28 4 124 1 bfrD Probable TonB-dependent receptor BfrD Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Q9Z3Q5 0.00022 48 27 8 199 3 rhtA Rhizobactin receptor Rhizobium meliloti (strain 1021)
A0A0H2ZI93 0.000237 48 27 4 121 2 cntO Metal-pseudopaline receptor CntO Pseudomonas aeruginosa (strain UCBPP-PA14)
Q9HUX3 0.000263 48 27 4 121 2 cntO Metal-pseudopaline receptor CntO Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Q9ZA21 0.000319 47 30 7 135 1 hgpA Hemoglobin and hemoglobin-haptoglobin-binding protein A Haemophilus influenzae
Q47952 0.000668 47 28 5 139 1 hgbA Hemoglobin and hemoglobin-haptoglobin-binding protein Haemophilus ducreyi (strain 35000HP / ATCC 700724)

  • Number of RefSeq hits:

General

Source Morganella morganii S2
Locus tag EHELCC_05140
Feature type CDS
Gene -
Product Colicin I receptor
Location 16792 - 18831 (strand: -1)
Length 2040 (nucleotides) / 679 (amino acids)

Contig

Accession ZDB_215
Length 284267 nucleotides
Topology linear
Plasmid False

Orthology

Orthogroup group_52
Orthogroup size 14
N. genomes 7

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Genomic region

Domains

PF00593 TonB dependent receptor-like, beta-barrel
PF07715 TonB-dependent Receptor Plug Domain

COG entry Annotation(s)

ID Function(s) descr. Function(s) cat. Description
COG4771 Inorganic ion transport and metabolism (P) P Outer membrane receptor for ferrienterochelin and colicins

Kegg Ortholog Annotation(s)

KO Description Pathways Modules
K16089 outer membrane receptor for ferrienterochelin and colicins - -

Virulence factor Annotation(s)

VF gene ID Protein VF ID Category
VFG012633 TonB-dependent siderophore receptor IreA VF1117 Nutritional/Metabolic factor

Protein Sequence

MNASFKRSLLAVAVMSAATAAYAENKDDTIVVTASGFAQEMRDAPASITVITKEQLQNKPAANLIDMVKDVEGVSVIGGSLKPDISIRGLSGDYTLIMVDGRRQNSREFRPNGSGGYEAGFIPPVEAIERIEVIRGPMSSLYGSDAMGGVINIITKAVADEWHGSMGMGGIIQESKDYGNSANTDFYVSGPLIKDKLGLQVYGGLNYRREDKLLEGTPRKDDKNITAKLAFTPIEGQKFLAEVGRSTQEHTSTPGKSIDETTTRGGIVQKNNKSEVHNNRNHWALTWKGDWDEINSEVSVYQENTIRKTNTGKWNKVSEDWVMAYEARQPEVTNTVVDGKVTAFLPSNVLTVGGQYQYAKLKDDSVIKNKQTVTEKMTAEQKALFVEDEFSVTDDLTLTGGLRMDDHEFYGKHWNPRAYAVYKLTDEITIKGGVAKAFRAPTLRELSPNFGTSTQGGAAIMYGNRDLKPETSVTEELGIAYDHESGFSASATLFNTEFKNKLTSYQVAGQTDPLTGLNMFIYDNVGKANIRGVEMASRIPVAEKWNLNLNYTFTDSERKSDDEKLNGKSLKGQPLEMTPRHMANARLDWQYRPDMNFYTQANYTGKQVWAAQRNGAKQPRERSGITTLDLGMTYQVMPNALLNFAVLNIANEKGDDIETNGNWQIDEGRRYWANLKLNF

Flanking regions ( +/- flanking 50bp)

TTCTCATTTAATATTTCAAATAAAAAATATCAATCCAGTCAGGGAATAATATGAACGCCTCATTCAAACGCTCACTGCTTGCTGTTGCTGTTATGTCAGCGGCCACCGCCGCTTATGCTGAAAATAAAGATGACACCATCGTGGTTACCGCTTCCGGTTTTGCGCAGGAAATGCGCGATGCACCGGCGAGTATCACCGTTATCACCAAGGAGCAGTTACAAAATAAACCAGCTGCCAACCTGATTGACATGGTGAAAGATGTGGAAGGTGTCAGTGTGATCGGCGGTAGCCTGAAGCCGGATATCAGCATCCGTGGTCTGTCCGGGGATTACACCCTGATTATGGTGGATGGTCGTCGTCAGAACAGCCGTGAATTCCGCCCGAACGGCAGCGGCGGTTACGAAGCCGGGTTTATTCCGCCGGTGGAAGCCATTGAACGCATTGAAGTGATCCGCGGACCGATGTCCTCCCTGTATGGTTCCGATGCGATGGGTGGTGTGATTAACATCATCACTAAAGCAGTGGCAGACGAATGGCACGGCTCAATGGGTATGGGCGGTATCATTCAGGAAAGTAAAGATTACGGTAACTCCGCAAATACGGATTTCTATGTCTCCGGGCCGCTGATTAAAGACAAGCTGGGGTTACAGGTTTACGGCGGGCTGAACTATCGCCGCGAAGATAAACTCCTGGAAGGTACACCGCGCAAAGACGACAAAAATATCACCGCTAAACTGGCCTTTACGCCGATCGAAGGGCAGAAATTCCTTGCGGAAGTCGGGCGCAGCACACAGGAACACACATCTACCCCGGGGAAATCGATTGATGAGACAACTACCCGTGGCGGTATCGTTCAGAAGAACAACAAATCCGAAGTACACAACAATCGTAACCACTGGGCGCTGACCTGGAAAGGTGACTGGGACGAAATTAACAGTGAAGTGAGTGTGTATCAGGAAAATACCATCCGTAAAACCAATACCGGCAAATGGAATAAAGTCAGTGAAGACTGGGTCATGGCGTATGAAGCCCGCCAGCCGGAAGTCACCAATACCGTGGTTGACGGAAAGGTCACTGCATTCCTGCCGTCTAACGTCCTGACTGTCGGCGGACAATATCAGTATGCCAAACTGAAAGATGATTCCGTGATTAAAAACAAACAGACAGTCACAGAAAAAATGACTGCTGAGCAGAAAGCACTGTTTGTGGAAGATGAATTCAGTGTAACCGACGACCTGACGCTGACCGGCGGTCTGCGTATGGACGACCATGAATTCTACGGTAAACACTGGAACCCGCGTGCCTATGCCGTCTATAAACTGACCGATGAAATCACCATCAAAGGTGGCGTGGCGAAAGCCTTCCGGGCCCCGACACTGCGCGAGTTAAGCCCGAATTTCGGAACGTCCACACAAGGTGGTGCGGCTATCATGTACGGTAACCGTGACCTGAAACCGGAAACCAGCGTGACAGAAGAACTGGGGATTGCTTATGACCACGAATCCGGTTTCTCTGCCAGTGCAACCCTGTTTAACACCGAATTCAAGAACAAGCTGACCAGCTACCAGGTCGCCGGTCAAACCGATCCGCTGACCGGCCTGAATATGTTTATCTACGATAACGTGGGTAAAGCGAATATCCGTGGTGTGGAAATGGCTTCCCGTATTCCGGTGGCAGAAAAATGGAATCTGAACCTGAACTACACCTTCACTGATTCAGAACGTAAGAGTGACGACGAAAAACTCAACGGAAAATCCCTGAAAGGACAACCGCTGGAAATGACACCGCGTCATATGGCGAATGCCAGACTTGACTGGCAGTACCGCCCGGATATGAACTTCTACACTCAGGCAAACTACACCGGCAAACAGGTCTGGGCAGCACAGCGTAACGGGGCAAAACAGCCGCGTGAACGCAGCGGGATCACCACCCTCGACCTCGGTATGACCTACCAGGTTATGCCAAACGCTCTGCTGAACTTCGCAGTACTGAACATCGCCAACGAGAAAGGGGATGATATCGAGACTAACGGGAACTGGCAGATCGATGAAGGGCGCCGGTATTGGGCTAATCTGAAACTGAATTTCTGATTACGCGTCATCCTTCGCCCTGTGGCGGCGTTGGCTGCTCTCAGGAAACC