VFG049099


Help to interpret the results

Three outputs have been generated:
General: this result contains the description and frequency of the selected Virulence factors VFG049099, of which KO pathways and KO modules it is part. Additionally, its occurence in the database is reported.
Proteins list: list of occurences of the Virulence factors within the database. 2 occurences are identified. The table reports the orthogroup, the organism in which each occurrence has been found, and the locus tag enriched by start and stop position, strand, gene name and product.
Clicking on the Ortohgroup name or locus you will be redirected to further info.
Profiles: Phylogenetic tree annotated with
- the presence of the Virulence factor(s) of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Virulence factors has been clustered.
In red the Virulence factors with positive hit(s) in the corresponding genome.
In green the discrepencies between orthogroup clustering and Virulence factors prediction. Green homologs (same orthogroup) are not positive hit(s) for the considered Virulence factors.

Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Virulence factors prediction.

Description

Protein NAD-dependent epimerase
VF ID VF0561
Category Immune modulation
Protein ID WP_014230054
Characteristics In K. pneumoniae there are nine main O-serotypes. Three of these, O1, O2, and O3, are responsible for almost 80% of all Klebsiella infections.; Compared with other Enterobacteriaceae, such as Escherichia coli 161 defined O serotypes and Shigella flexneri at least 47 O serotypes, Klebsiella has a surprisingly low number of reported O serotypes which promises a more viable alternative for vaccine development compared with K-antigen-based vaccines; The O-antigen biosynthesis enzymes are encoded on the rfb locus.
Function Resistant to serum complement; also play a role in protecting bacteria from antimicrobial peptides, including polymyxin antibiotics
Vf_category_id VFC0258

Occurence in the database

VFG049099 is associated with 2 different proteins (see tab "Protein list" and "Profile")
The 2 proteins are classified into 1 different orthogroup(s)
# Orthogroup Locus Start Stop S. Gene Product Organism
0 group_271 PMI_RS07210 1579323 1580330 -1 NAD-dependent epimerase Proteus mirabilis HI4320
1 group_271 PMI_RS15765 3500964 3501974 -1 NAD-dependent epimerase Proteus mirabilis HI4320