Help to interpret the results
Three outputs have been generated:
General: this tab contains the description, occurence in the database and other information related to the selected Virulence factor VFG042734
Protein list: lists the 7 occurences of the Virulence factor within the database. The table reports information on each occurence.
Profile: phylogenetic tree annotated with
- the presence of the Virulence factor of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Virulence factor has been clustered.
Orthogroups are shown in red if they are annotated with that particular Virulence factor in a given genome , in green otherwise, i.e. if there is a discrepency between orthogroup clustering and Virulence factor prediction.
Green homologs (same orthogroup) are not positive hit(s) for the considered Virulence factor.
Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Virulence factor prediction.
Description
| Protein | cAMP-regulatory protein |
|---|---|
| VF ID | VF0082 |
| Category | Adherence |
| Protein ID | NP_249343 |
| Characteristics | PilA, B, C, D, E, F, M, N, O, P, Q, T, U, V, W, X, Y1, Y2, Z, and fimT, U, V are involved in the biogenesis and mechanical function of pili, pilG, H, I, K, chpA, B, C, D, E, pilS, R, fimS, rpoN, algR, algU, and vfr are involved in transcriptional regulation and chemosensory pathways that control the expression or activity of the twitching motility of the pili |
| Function | Attaches to host cells, but not to mucin, causing a twitching motility that allows the bacteria to move along the cell surface; biofilm formation |
| Mechanism | The C-terminal receptor-binding domain of pilin binds to asialoGM1 gangliosides on host cells. Generally, GM1 gangliosides contain a sialic acid moiety. P.aeruginosa produces a neuraminidase which removes sialic acid residues from the GM1 to form the asialoGM1, which is a better receptor for the pili; The asialoGM1 is present in increased abundance on the surface of cystic fibrosis respiratory epithelial cells |
| Vf_category_id | VFC0001 |
Occurence in the database
| VFG042734 is associated with 7 different proteins |
| The 7 proteins are classified into 1 different orthogroup(s) |
| Orthogroup | Locus | Start | Stop | S. | Gene | Product | Organism | |
|---|---|---|---|---|---|---|---|---|
| 0 | group_1741 | FBDBKF_11845 | 19552 | 20184 | 1 | crp | cAMP-activated global transcriptional regulator CRP | Morganella morganii S1 |
| 1 | group_1741 | EHELCC_14460 | 114521 | 115153 | -1 | crp | cAMP-activated global transcriptional regulator CRP | Morganella morganii S2 |
| 2 | group_1741 | NLDBIP_15555 | 118458 | 119090 | -1 | crp | cAMP-activated global transcriptional regulator CRP | Morganella morganii S4 |
| 3 | group_1741 | LHKJJB_15055 | 19552 | 20184 | 1 | crp | cAMP-activated global transcriptional regulator CRP | Morganella morganii S3 |
| 4 | group_1741 | HKOGLL_14175 | 6215 | 6847 | 1 | crp | cAMP-activated global transcriptional regulator CRP | Morganella morganii S5 |
| 5 | group_1741 | F4V73_RS14805 | 197344 | 197976 | -1 | crp | cAMP-activated global transcriptional regulator CRP | Morganella psychrotolerans |
| 6 | group_1741 | PMI_RS13930 | 3093805 | 3094437 | 1 | crp | cAMP-activated global transcriptional regulator CRP | Proteus mirabilis HI4320 |
