VFG042734


Help to interpret the results

Three outputs have been generated:
General: this result contains the description and frequency of the selected Virulence factors VFG042734, of which KO pathways and KO modules it is part. Additionally, its occurence in the database is reported.
Proteins list: list of occurences of the Virulence factors within the database. 7 occurences are identified. The table reports the orthogroup, the organism in which each occurrence has been found, and the locus tag enriched by start and stop position, strand, gene name and product.
Clicking on the Ortohgroup name or locus you will be redirected to further info.
Profiles: Phylogenetic tree annotated with
- the presence of the Virulence factor(s) of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Virulence factors has been clustered.
In red the Virulence factors with positive hit(s) in the corresponding genome.
In green the discrepencies between orthogroup clustering and Virulence factors prediction. Green homologs (same orthogroup) are not positive hit(s) for the considered Virulence factors.

Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Virulence factors prediction.

Description

Protein cAMP-regulatory protein
VF ID VF0082
Category Adherence
Protein ID NP_249343
Characteristics PilA, B, C, D, E, F, M, N, O, P, Q, T, U, V, W, X, Y1, Y2, Z, and fimT, U, V are involved in the biogenesis and mechanical function of pili, pilG, H, I, K, chpA, B, C, D, E, pilS, R, fimS, rpoN, algR, algU, and vfr are involved in transcriptional regulation and chemosensory pathways that control the expression or activity of the twitching motility of the pili
Function Attaches to host cells, but not to mucin, causing a twitching motility that allows the bacteria to move along the cell surface; biofilm formation
Mechanism The C-terminal receptor-binding domain of pilin binds to asialoGM1 gangliosides on host cells. Generally, GM1 gangliosides contain a sialic acid moiety. P.aeruginosa produces a neuraminidase which removes sialic acid residues from the GM1 to form the asialoGM1, which is a better receptor for the pili; The asialoGM1 is present in increased abundance on the surface of cystic fibrosis respiratory epithelial cells
Vf_category_id VFC0001

Occurence in the database

VFG042734 is associated with 7 different proteins (see tab "Protein list" and "Profile")
The 7 proteins are classified into 1 different orthogroup(s)
# Orthogroup Locus Start Stop S. Gene Product Organism
0 group_1698 FBDBKF_11845 19552 20184 1 crp cAMP-activated global transcriptional regulator CRP Morganella morganii S1
1 group_1698 EHELCC_14460 114521 115153 -1 crp cAMP-activated global transcriptional regulator CRP Morganella morganii S2
2 group_1698 NLDBIP_15555 118458 119090 -1 crp cAMP-activated global transcriptional regulator CRP Morganella morganii S4
3 group_1698 LHKJJB_15055 19552 20184 1 crp cAMP-activated global transcriptional regulator CRP Morganella morganii S3
4 group_1698 HKOGLL_14175 6215 6847 1 crp cAMP-activated global transcriptional regulator CRP Morganella morganii S5
5 group_1698 F4V73_RS14805 197344 197976 -1 crp cAMP-activated global transcriptional regulator CRP Morganella psychrotolerans
6 group_1698 PMI_RS13930 3093805 3094437 1 crp cAMP-activated global transcriptional regulator CRP Proteus mirabilis HI4320