VFG018243
Help to interpret the results
Three outputs have been generated:
General: this result contains the description and frequency of the selected Virulence factors VFG018243, of which KO pathways and KO modules it is part. Additionally, its occurence in the database is reported.
Proteins list: list of occurences of the Virulence factors
within the database. 6 occurences are identified.
The table reports the orthogroup, the organism in which each occurrence has been found, and the locus tag enriched by start and stop position, strand, gene name and product.
Clicking on the Ortohgroup name or locus you will be redirected to further info.
Profiles: Phylogenetic tree annotated with
- the presence of the Virulence factor(s) of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Virulence factors has been clustered.
In red the Virulence factors with positive hit(s) in the corresponding genome.
In green the discrepencies between orthogroup clustering and Virulence factors prediction.
Green homologs (same orthogroup) are not positive hit(s) for the considered Virulence factors.
Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Virulence factors prediction.
Description
| Protein |
S-ribosylhomocysteinase |
| VF ID |
VF0406 |
| Category |
Biofilm |
| Protein ID |
WP_005462534 |
| Characteristics |
AI-2 is produced and detected by a wide variety of bacteria and is presumed to facilitate interspecies communications. |
| Structure |
Furanosyl borate diester (2S,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran borate |
| Function |
LuxPQ receptor complex responds to the AI-2 molecule. Information from AI-2 is transduced through the LuxO protein to control the levels of the master transcription factor HapR. At low cell density, in the absence of autoinducers, HapR is not produced, so virulence factors are expressed and biofilms are formed. At high cell density, in the presence of autoinducers, LuxO is inactivated, HapR is produced, and it represses genes for virulence factor production and biofilm formation. These events are proposed to allow V. cholerae to leave the host, re-enter the environment in large numbers and initiate a new cycle of infection. |
| Vf_category_id |
VFC0271 |
Occurence in the database
| VFG018243 is associated with 6 different proteins (see tab "Protein list" and "Profile") |
|
The 6 proteins are classified into 1 different orthogroup(s)
|
