VFG012278
Help to interpret the results
Three outputs have been generated:
General: this result contains the description and frequency of the selected Virulence factors VFG012278, of which KO pathways and KO modules it is part. Additionally, its occurence in the database is reported.
Proteins list: list of occurences of the Virulence factors
within the database. 1 occurences are identified.
The table reports the orthogroup, the organism in which each occurrence has been found, and the locus tag enriched by start and stop position, strand, gene name and product.
Clicking on the Ortohgroup name or locus you will be redirected to further info.
Profiles: Phylogenetic tree annotated with
- the presence of the Virulence factor(s) of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Virulence factors has been clustered.
In red the Virulence factors with positive hit(s) in the corresponding genome.
In green the discrepencies between orthogroup clustering and Virulence factors prediction.
Green homologs (same orthogroup) are not positive hit(s) for the considered Virulence factors.
Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Virulence factors prediction.
Description
Protein |
Type-1 fimbrial protein, A chain precursor |
VF ID |
VF0221 |
Category |
Adherence |
Protein ID |
WP_000695554 |
Characteristics |
Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases |
Structure |
FimC-FimH chaperone adhesin complex: 1QUN |
Function |
Makes an important contribution to colonization of the bladder |
Mechanism |
FimH is the adhesin protein binding to mannose-containing glycoprotein receptors, known as uroplakins, which are located on the luminal surface of the bladder epithelial cells. This binding is followed by invasion of uroepithelia cells |
Vf_category_id |
VFC0001 |
Occurence in the database
VFG012278 is associated with 1 different proteins (see tab "Protein list" and "Profile") |
The 1 proteins are classified into 1 different orthogroup(s)
|
# |
Orthogroup |
Locus |
Start |
Stop |
S. |
Gene |
Product |
Organism |
0 |
group_78 |
PMI_RS17120 |
3766390 |
3766956 |
1 |
fimA |
type 1 fimbrial major subunit FimA |
Proteus mirabilis HI4320 |