VFG012278
Help to interpret the results
Three outputs have been generated:
General: this tab contains the description, occurence in the database and other information related to the selected Virulence factor VFG012278
Protein list: lists the 1 occurences of the Virulence factor within the database. The table reports information on each occurence.
Profile: phylogenetic tree annotated with
- the presence of the Virulence factor of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Virulence factor has been clustered.
Orthogroups are shown in red if they are annotated with that particular Virulence factor in a given genome , in green otherwise, i.e. if there is a discrepency between orthogroup clustering and Virulence factor prediction.
Green homologs (same orthogroup) are not positive hit(s) for the considered Virulence factor.
Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Virulence factor prediction.
Description
| Protein |
Type-1 fimbrial protein, A chain precursor |
| VF ID |
VF0221 |
| Category |
Adherence |
| Protein ID |
WP_000695554 |
| Characteristics |
Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases |
| Structure |
FimC-FimH chaperone adhesin complex: 1QUN |
| Function |
Makes an important contribution to colonization of the bladder |
| Mechanism |
FimH is the adhesin protein binding to mannose-containing glycoprotein receptors, known as uroplakins, which are located on the luminal surface of the bladder epithelial cells. This binding is followed by invasion of uroepithelia cells |
| Vf_category_id |
VFC0001 |
Occurence in the database
| VFG012278 is associated with 1 different
proteins
|
|
The 1 proteins are classified into 1 different orthogroup(s)
|
|
Orthogroup |
Locus |
Start |
Stop |
S. |
Gene |
Product |
Organism |
| 0 |
group_197 |
PMI_RS17120 |
3766390 |
3766956 |
1 |
fimA |
type 1 fimbrial major subunit FimA |
Proteus mirabilis HI4320 |
