K00031


Help to interpret the results

Three outputs have been generated:
General: this result contains the description and frequency of the selected Kegg Orthologs K00031, of which KO pathways and KO modules it is part. Additionally, its occurence in the database is reported.
Proteins list: list of occurences of the Kegg Orthologs within the database. 7 occurences are identified. The table reports the orthogroup, the organism in which each occurrence has been found, and the locus tag enriched by start and stop position, strand, gene name and product.
Clicking on the Ortohgroup name or locus you will be redirected to further info.
Profiles: Phylogenetic tree annotated with
- the presence of the Kegg Ortholog(s) of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Kegg Orthologs has been clustered.
In red the Kegg Orthologs with positive hit(s) in the corresponding genome.
In green the discrepencies between orthogroup clustering and Kegg Orthologs prediction. Green homologs (same orthogroup) are not positive hit(s) for the considered Kegg Orthologs.

Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Kegg Orthologs prediction.

Description

External link K00031
KO K00031
Description isocitrate dehydrogenase [EC:1.1.1.42]

KO part of 11 pathways

Citrate cycle (TCA cycle)
Glutathione metabolism
Carbon fixation pathways in prokaryotes
Metabolic pathways
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Carbon metabolism
2-Oxocarboxylic acid metabolism
Biosynthesis of amino acids
Peroxisome
Central carbon metabolism in cancer

KO part of 4 modules

M00009 Central carbohydrate metabolism Citrate cycle (TCA cycle, Krebs cycle)
M00010 Central carbohydrate metabolism Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
M00173 Carbon fixation Reductive citrate cycle (Arnon-Buchanan cycle)
M00740 Other carbohydrate metabolism Methylaspartate cycle

Occurence in the database

K00031 is associated with 7 different proteins (see tab "Protein list" and "Profile")
The 7 proteins are classified into 1 different orthogroup(s)
# Orthogroup Locus Start Stop S. Gene Product Organism
0 group_1937 PMI_RS04380 982975 984228 1 icd NADP-dependent isocitrate dehydrogenase Proteus mirabilis HI4320
1 group_1937 FBDBKF_14545 3630 4883 -1 icd NADP-dependent isocitrate dehydrogenase Morganella morganii S1
2 group_1937 EHELCC_15350 33706 34959 -1 icd NADP-dependent isocitrate dehydrogenase Morganella morganii S2
3 group_1937 NLDBIP_15880 33706 34959 -1 icd NADP-dependent isocitrate dehydrogenase Morganella morganii S4
4 group_1937 LHKJJB_15960 81727 82980 1 icd NADP-dependent isocitrate dehydrogenase Morganella morganii S3
5 group_1937 HKOGLL_15080 80939 82192 1 icd NADP-dependent isocitrate dehydrogenase Morganella morganii S5
6 group_1937 F4V73_RS07340 1531909 1533162 -1 icd NADP-dependent isocitrate dehydrogenase Morganella psychrotolerans