Valine, leucine and isoleucine degradation

Help to interpret the results


The page contains two contents:
General: this table lists the KO entries and their description specific to this pathway, and provides their frequencies in and in the whole dataset.
Profile + homologs: the distribution of the Kegg entries of Valine, leucine and isoleucine degradation Kegg pathway is displayed here. Given a Kegg entry and a genome, a red box indicates that one or more loci have been annotated with, while a green box indicates that no locus/loci has(have) been annotated with it, but it/they is/are part of an Orthologous group in which other members have been annotated with that Kegg entry, so it is likely that this copy(ies) also performs this Kegg function.

Check the composition of the Valine, leucine and isoleucine degradation pathway


KO Description All occurrences
K00020 3-hydroxyisobutyrate dehydrogenase [EC:1.1.1.31] 0
K00022 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35] 0
K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] 7
K00140 malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.18 1.2.1.27] 0
K00149 aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.47 1.2.1.3] 0
K00157 aldehyde oxidase [EC:1.2.3.1] 0
K00166 2-oxoisovalerate dehydrogenase E1 component subunit alpha [EC:1.2.4.4] 0
K00167 2-oxoisovalerate dehydrogenase E1 component subunit beta [EC:1.2.4.4] 0
K00186 2-oxoisovalerate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.7] 0
K00187 2-oxoisovalerate ferredoxin oxidoreductase beta subunit [EC:1.2.7.7] 0
K00188 2-oxoisovalerate ferredoxin oxidoreductase delta subunit [EC:1.2.7.7] 0
K00189 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.7 1.2.7.1] 0
K00248 butyryl-CoA dehydrogenase [EC:1.3.8.1] 0
K00249 acyl-CoA dehydrogenase [EC:1.3.8.7] 0
K00253 isovaleryl-CoA dehydrogenase [EC:1.3.8.4] 0
K00263 leucine dehydrogenase [EC:1.4.1.9] 0
K00271 valine dehydrogenase (NAD+) [EC:1.4.1.23] 0
K00382 dihydrolipoyl dehydrogenase [EC:1.8.1.4] 7
K00626 acetyl-CoA C-acetyltransferase [EC:2.3.1.9] 13
K00632 acetyl-CoA acyltransferase [EC:2.3.1.16] 7
K00822 beta-alanine--pyruvate transaminase [EC:2.6.1.18] 0
K00826 branched-chain amino acid aminotransferase [EC:2.6.1.42] 7
K00827 alanine-glyoxylate transaminase / (R)-3-amino-2-methylpropionate-pyruvate transaminase [EC:2.6.1.44 2.6.1.40] 0
K01027 3-oxoacid CoA-transferase [EC:2.8.3.5] 0
K01028 3-oxoacid CoA-transferase subunit A [EC:2.8.3.5] 0
K01029 3-oxoacid CoA-transferase subunit B [EC:2.8.3.5] 0
K01640 hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4] 0
K01641 hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10] 0
K01692 enoyl-CoA hydratase [EC:4.2.1.17] 0
K01782 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3] 7
K01825 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8] 7
K01847 methylmalonyl-CoA mutase [EC:5.4.99.2] 0
K01848 methylmalonyl-CoA mutase, N-terminal domain [EC:5.4.99.2] 0
K01849 methylmalonyl-CoA mutase, C-terminal domain [EC:5.4.99.2] 0
K01907 acetoacetyl-CoA synthetase [EC:6.2.1.16] 0
K01964 acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3] 0
K01965 propionyl-CoA carboxylase alpha chain [EC:6.4.1.3] 0
K01966 propionyl-CoA carboxylase beta chain [EC:6.4.1.3 2.1.3.15] 0
K01968 3-methylcrotonyl-CoA carboxylase alpha subunit [EC:6.4.1.4] 0
K01969 3-methylcrotonyl-CoA carboxylase beta subunit [EC:6.4.1.4] 0
K03334 L-amino-acid oxidase [EC:1.4.3.2] 0
K05605 3-hydroxyisobutyryl-CoA hydrolase [EC:3.1.2.4] 0
K05606 methylmalonyl-CoA/ethylmalonyl-CoA epimerase [EC:5.1.99.1] 0
K05607 methylglutaconyl-CoA hydratase [EC:4.2.1.18] 0
K07250 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase / 5-aminovalerate transaminase [EC:2.6.1.19 2.6.1.22 2.6.1.48] 0
K07508 acetyl-CoA acyltransferase 2 [EC:2.3.1.16] 0
K07509 acetyl-CoA acyltransferase [EC:2.3.1.16] 0
K07511 enoyl-CoA hydratase [EC:4.2.1.17] 0
K07513 acetyl-CoA acyltransferase 1 [EC:2.3.1.16] 0
K07514 enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8] 0
K07515 enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211] 0
K08683 3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase [EC:1.1.1.35 1.1.1.178] 0
K09478 short-chain 2-methylacyl-CoA dehydrogenase [EC:1.3.8.5] 0
K09699 2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase) [EC:2.3.1.168] 0
K11263 acetyl-CoA/propionyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.3.4.14] 0
K11381 2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4] 0
K11410 short-chain 2-methylacyl-CoA dehydrogenase [EC:1.3.8.5] 0
K11538 isobutyryl-CoA dehydrogenase [EC:1.3.99.-] 0
K13524 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase [EC:2.6.1.19 2.6.1.22] 0
K13766 methylglutaconyl-CoA hydratase [EC:4.2.1.18] 0
K14085 aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3] 0
K15036 acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3 2.1.3.15] 0
K15037 biotin carboxyl carrier protein 0
K18472 acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15] 0
K18660 malonyl-CoA/methylmalonyl-CoA synthetase [EC:6.2.1.76 6.2.1.-] 0
K18661 malonyl-CoA/methylmalonyl-CoA synthetase [EC:6.2.1.76 6.2.1.-] 0
K19312 acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15] 0
K22568 acetyl-CoA/propionyl-CoA carboxylase, PccX subunit [EC:6.4.1.2 6.4.1.3] 0
K23146 3-hydroxyisobutyrate/3-hydroxypropionate dehydrogenase [EC:1.1.1.31 1.1.1.59] 0