Homologs in group_346

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7 homologs were identified in 6 genomes with OrthoFinder.
The following table displays the locus tag of each homolog, the organism to which it belongs, the gene name and product.

Locus tag Identity Source Gene Product
FBDBKF_12050 FBDBKF_12050 89.1 Morganella morganii S1 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
EHELCC_14255 EHELCC_14255 89.1 Morganella morganii S2 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
NLDBIP_15350 NLDBIP_15350 89.1 Morganella morganii S4 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
LHKJJB_15260 LHKJJB_15260 89.1 Morganella morganii S3 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
HKOGLL_14380 HKOGLL_14380 89.1 Morganella morganii S5 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
F4V73_RS14595 F4V73_RS14595 88.4 Morganella psychrotolerans spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
F4V73_RS17820 F4V73_RS17820 36.2 Morganella psychrotolerans - HD domain-containing protein

Distribution of the homologs in the orthogroup group_346

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Number of homologs in each genome (first column) and amino-acid identity of the closest homolog (second column).

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Phylogeny of the RefSeq best hits of group_346

Swissprot accession Eval Score ID (%) N gaps Alignment length Annot score Gene Description Organism
P0AG26 0.0 1249 84 4 711 3 spoT Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase Shigella flexneri
P0AG24 0.0 1249 84 4 711 1 spoT Bifunctional (p)ppGpp synthase/hydrolase SpoT Escherichia coli (strain K12)
P0AG25 0.0 1249 84 4 711 3 spoT Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase Escherichia coli O157:H7
Q9KNM2 0.0 1083 72 1 708 1 spoT Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
P43811 0.0 807 57 3 682 3 spoT Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
O54408 0.0 565 39 10 726 1 relA GTP pyrophosphokinase Bacillus subtilis (strain 168)
Q54089 0.0 559 40 9 728 1 relA Bifunctional (p)ppGpp synthase/hydrolase RelA Streptococcus dysgalactiae subsp. equisimilis
P74007 0.0 549 40 8 703 3 spoT Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Q6GG70 0.0 546 40 8 717 3 relA GTP pyrophosphokinase Staphylococcus aureus (strain MRSA252)
P0A0E9 0.0 546 40 8 717 3 relA GTP pyrophosphokinase Staphylococcus aureus (strain MW2)
P0A0F0 0.0 546 40 8 717 3 relA GTP pyrophosphokinase Staphylococcus aureus
Q6G8T5 0.0 546 40 8 717 3 relA GTP pyrophosphokinase Staphylococcus aureus (strain MSSA476)
Q99TL8 0.0 546 40 8 717 1 relA GTP pyrophosphokinase Staphylococcus aureus (strain N315)
Q931Q4 0.0 543 39 8 717 1 relA GTP pyrophosphokinase Staphylococcus aureus (strain Mu50 / ATCC 700699)
O52177 1.41e-179 533 39 11 741 3 relA GTP pyrophosphokinase Myxococcus xanthus
Q8CS97 2.04e-176 524 39 10 721 3 relA GTP pyrophosphokinase Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)
Q5HNR8 2.04e-176 524 39 10 721 3 relA GTP pyrophosphokinase Staphylococcus epidermidis (strain ATCC 35984 / DSM 28319 / BCRC 17069 / CCUG 31568 / BM 3577 / RP62A)
O87331 1.21e-175 523 38 8 726 3 relA GTP pyrophosphokinase Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534)
P52560 1.38e-175 526 38 8 741 3 relA GTP pyrophosphokinase Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
P9WHG9 2.64e-175 521 38 8 729 1 relA Bifunctional (p)ppGpp synthase/hydrolase RelA Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WHG8 2.64e-175 521 38 8 729 3 relA Bifunctional (p)ppGpp synthase/hydrolase RelA Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
P66015 1.71e-174 521 38 8 729 3 relA Probable GTP pyrophosphokinase Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
O67012 2.38e-174 518 39 10 700 3 spoT Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase Aquifex aeolicus (strain VF5)
Q49640 5.11e-174 520 39 10 734 3 relA Probable GTP pyrophosphokinase Mycobacterium leprae (strain TN)
O85709 7.86e-168 506 38 9 739 3 relA GTP pyrophosphokinase Streptomyces antibioticus
Q8YG65 8.36e-158 477 39 10 696 1 rsh GTP pyrophosphokinase rsh Brucella melitensis biotype 1 (strain ATCC 23456 / CCUG 17765 / NCTC 10094 / 16M)
Q57E90 1.42e-157 476 39 10 696 1 rsh GTP pyrophosphokinase rsh Brucella abortus biovar 1 (strain 9-941)
Q2YN11 1.42e-157 476 39 10 696 3 rsh GTP pyrophosphokinase rsh Brucella abortus (strain 2308)
A5VPI9 1.66e-157 476 39 10 696 3 rsh GTP pyrophosphokinase rsh Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)
Q8CY42 3.24e-156 473 38 10 696 1 rsh GTP pyrophosphokinase rsh Brucella suis biovar 1 (strain 1330)
O34098 2.12e-147 450 34 17 751 3 spoT Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase Spiroplasma citri
P44644 2.96e-127 398 32 15 722 3 relA GTP pyrophosphokinase Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
P55133 2.86e-124 390 32 10 641 3 relA GTP pyrophosphokinase Photobacterium angustum (strain S14 / CCUG 15956)
P0AG23 6.72e-121 381 32 11 682 3 relA GTP pyrophosphokinase Shigella flexneri
P0AG20 6.72e-121 381 32 11 682 1 relA GTP pyrophosphokinase Escherichia coli (strain K12)
P0AG21 6.72e-121 381 32 11 682 3 relA GTP pyrophosphokinase Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
P0AG22 6.72e-121 381 32 11 682 3 relA GTP pyrophosphokinase Escherichia coli O157:H7
O51216 3.52e-119 374 40 4 478 3 spoT Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)
Q9AYT5 6.95e-95 317 38 13 532 2 RSH1 Putative GTP diphosphokinase RSH1, chloroplastic Oryza sativa subsp. japonica
P0DKG8 2.25e-94 315 38 13 530 1 RSH1 Putative GTP diphosphokinase RSH1, chloroplastic Arabidopsis thaliana
F4JHA2 1.12e-92 310 38 14 531 1 RSH1 Putative GTP diphosphokinase RSH1, chloroplastic Arabidopsis thaliana
Q9M5P5 7.98e-83 280 42 8 387 2 RSH3 Probable GTP diphosphokinase RSH3, chloroplastic Arabidopsis thaliana
Q9SYH1 4.54e-82 278 42 8 390 2 RSH3 Probable GTP diphosphokinase RSH3, chloroplastic Arabidopsis thaliana
Q9LVJ3 7.6e-81 275 44 5 349 2 RSH2 Probable GTP diphosphokinase RSH2, chloroplastic Arabidopsis thaliana
Q9M5P6 6.34e-79 270 43 5 349 2 RSH2 Probable GTP diphosphokinase RSH2, chloroplastic Arabidopsis thaliana
Q67UU0 6.14e-73 253 42 6 348 2 RSH3 Probable GTP diphosphokinase RSH3, chloroplastic Oryza sativa subsp. japonica
Q7XAP4 1.83e-69 244 41 6 348 2 RSH2 Probable GTP diphosphokinase RSH2, chloroplastic Oryza sativa subsp. japonica
P47520 1.29e-67 239 28 21 661 3 spoT Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
P75386 1.28e-62 225 27 18 657 3 spoT Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)
Q84R11 9.55e-36 146 28 7 342 2 CRSH Probable GTP diphosphokinase CRSH, chloroplastic Arabidopsis thaliana
Q75IS2 1.7e-30 130 28 8 341 1 CRSH3 GTP diphosphokinase CRSH3, chloroplastic Oryza sativa subsp. japonica
Q6ATB4 4.69e-28 123 28 7 320 1 CRSH1 GTP diphosphokinase CRSH1, chloroplastic Oryza sativa subsp. japonica
Q6ATB2 1.99e-26 117 28 11 348 1 CRSH2 GTP diphosphokinase CRSH2, chloroplastic Oryza sativa subsp. japonica
Q4UMH6 5.93e-18 92 25 7 300 4 RF_0381 Putative ankyrin repeat protein RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)
Q568P1 2.74e-15 77 40 3 115 2 hddc3 Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 Danio rerio
Q9VAM9 1.03e-14 76 41 3 118 1 Mesh1 Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 Drosophila melanogaster
Q28C98 1.79e-12 69 38 3 128 2 hddc3 Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 Xenopus tropicalis
Q8N4P3 1.63e-11 67 37 3 136 1 HDDC3 Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 Homo sapiens
Q9D114 1.73e-11 67 37 3 135 1 Hddc3 Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 Mus musculus
P29941 1.08e-08 58 33 3 129 4 None Uncharacterized 19.2 kDa protein in cobO 3'region Sinorhizobium sp.
P39583 3.84e-05 48 37 2 91 1 ywaC GTP pyrophosphokinase YwaC Bacillus subtilis (strain 168)

  • Number of RefSeq hits:

General

Source Proteus mirabilis HI4320
Locus tag PMI_RS14155
Feature type CDS
Gene spoT
Product bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
Location 3140945 - 3143071 (strand: 1)
Length 2127 (nucleotides) / 708 (amino acids)

Contig

Accession NC_010554
Length 4063606 nucleotides
Topology circular
Plasmid False

Orthology

Orthogroup group_346
Orthogroup size 8
N. genomes 7

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Genomic region

Domains

PF02824 TGS domain
PF04607 Region found in RelA / SpoT proteins
PF13291 ACT domain
PF13328 HD domain
PF19296 RelA/SpoT, AH and RIS domains

COG entry Annotation(s)

ID Function(s) descr. Function(s) cat. Description
COG0317 Signal transduction mechanisms (T)
Transcription (K)		 TK (p)ppGpp synthase/hydrolase, HD superfamily

Kegg Ortholog Annotation(s)

KO Description Pathways Modules
K01139 GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2] Purine metabolism
Metabolic pathways		 -

Protein Sequence

MYLFESLNQIVQKYLPPEQVEQLKKAFIVARDAHEGQTRSSGEPYITHPVAVACILADMRLDHQTLMAALLHDVIEDTPATFKDIETLFGSTVADLVEGVSKLDKLKFRDKKEAQAENFRKMIMAMVKDIRVILIKLADRTHNMRTLGSLRPDKRRRIARETLEIYSPLAHRLGIHHIKTELEELGFEALHPNRYRVIKEVVKAARGNRKEMINKILSEIEGRLTEASIQCKVNGREKHLYSIYRKMLLKEQRFHSIMDIYAFRVIVKDVDTCYRVLGQMHSLYKPRPGRVKDYIAIPKANGYQSLHTSLIGPHGVPVEVQIRTEDMDQMAEMGVAAHWAYKEQGEQPGTTAQVRAQRWMQSLLELQQSAGSSFEFIENVKSDLFPDEIYVFTPEGRIVELPTGATPVDFAYAVHTDIGHACVGARVDRQPYPLSQSLRTGQTVEIITAPGARPNAAWLNFVVSSRARSKIRQLLKNLKREDSINLGRRLLNHALGHHKVADIPLENIERELKRMKLHSMDDIMAEIGLGNAMSVVVARNLLIDNQQQEEHTHLSITNDETPKLPIKGADGVLISFAKCCRPIPGDPIVAHISPGKGLVIHHESCRNIRGYQKEPEKFMPVEWDKDIDGDFITEIKVDMINHQGALANLTAAINDANSSIQSMNTEEKDGRVYCAFIRLTAKDRIQLANIMRKLRIMPDVLRVSRNKN

Flanking regions ( +/- flanking 50bp)

ATTGCGGAAGGTCGTCGTTAATCGTCTCATAAAATAGGGGTAGGTCTGCCTTGTACCTGTTTGAAAGCCTGAATCAAATCGTTCAAAAATACTTGCCACCTGAGCAAGTTGAACAACTCAAAAAAGCCTTTATCGTCGCCAGAGATGCCCACGAGGGGCAGACTCGTTCAAGTGGTGAGCCTTATATTACTCACCCTGTGGCGGTTGCCTGTATTCTTGCCGATATGCGATTAGATCATCAAACGCTAATGGCGGCATTGTTGCATGATGTCATTGAAGATACACCTGCGACATTTAAAGATATCGAAACTCTGTTTGGCAGTACGGTGGCAGATCTGGTTGAAGGCGTCTCAAAACTGGATAAATTAAAGTTTCGAGATAAAAAAGAGGCCCAGGCTGAAAACTTTCGCAAAATGATCATGGCGATGGTAAAAGACATTCGCGTTATTTTGATCAAATTGGCAGACCGAACTCACAATATGCGCACGCTGGGTTCACTACGCCCAGATAAACGTCGCCGTATTGCACGTGAAACGCTGGAAATTTATAGTCCTCTTGCTCACCGTTTAGGTATACACCATATTAAAACTGAGCTAGAAGAATTAGGCTTTGAGGCACTACATCCTAATCGCTACCGCGTGATTAAAGAAGTTGTTAAGGCAGCTCGTGGTAACCGTAAAGAGATGATTAATAAAATCCTCTCTGAAATTGAAGGGCGCCTTACAGAAGCGAGTATTCAATGCAAAGTTAACGGTCGCGAAAAACACCTTTATTCCATTTATCGTAAAATGTTGCTAAAAGAGCAACGTTTTCACTCAATTATGGATATTTATGCCTTTCGCGTCATCGTTAAAGATGTCGATACCTGCTATCGCGTGTTAGGCCAAATGCATAGCCTTTATAAACCTCGCCCTGGCCGCGTTAAAGACTATATTGCTATCCCCAAAGCTAATGGTTATCAATCCCTTCACACTTCGCTCATTGGTCCTCATGGTGTCCCTGTTGAAGTACAAATTCGTACCGAAGATATGGATCAAATGGCTGAAATGGGCGTTGCGGCCCATTGGGCTTATAAAGAGCAAGGTGAGCAGCCGGGGACAACAGCCCAAGTCAGAGCACAACGTTGGATGCAAAGTTTACTTGAATTGCAACAAAGTGCAGGTAGCTCTTTTGAATTTATCGAAAACGTGAAATCAGACCTTTTTCCTGATGAAATTTACGTTTTCACCCCAGAAGGTCGCATTGTTGAATTACCAACGGGTGCGACTCCGGTTGATTTTGCTTACGCAGTTCATACTGATATTGGTCATGCTTGTGTCGGTGCAAGGGTTGATAGACAACCTTATCCACTCTCACAGTCTTTACGTACCGGACAGACCGTTGAAATCATTACTGCGCCGGGTGCAAGACCAAATGCGGCTTGGTTAAACTTTGTCGTCAGTTCAAGAGCCCGTTCAAAGATAAGACAGTTGCTCAAAAATCTAAAACGTGAAGACTCTATTAATTTAGGTCGTCGTCTACTTAATCACGCTTTAGGCCATCATAAAGTGGCAGATATTCCGCTAGAAAATATTGAACGAGAGTTGAAGCGCATGAAGCTTCACTCAATGGACGATATTATGGCTGAGATAGGTTTAGGTAATGCGATGAGTGTTGTTGTGGCGCGTAACTTATTGATTGACAACCAACAACAAGAAGAACACACACATCTAAGCATAACCAATGACGAAACACCTAAATTACCTATTAAAGGGGCTGATGGTGTACTTATCTCATTTGCTAAATGTTGTCGCCCTATTCCTGGTGATCCTATTGTTGCGCACATTAGCCCTGGTAAAGGCTTAGTTATTCACCACGAATCTTGTCGTAATATTCGCGGTTATCAAAAAGAGCCAGAAAAATTCATGCCAGTTGAGTGGGATAAAGATATTGATGGTGATTTTATTACCGAAATCAAAGTCGATATGATAAACCATCAAGGTGCATTAGCGAATTTAACCGCAGCAATTAATGACGCTAATTCAAGCATTCAGAGCATGAATACCGAAGAGAAAGATGGACGCGTCTATTGTGCATTTATTCGACTGACAGCCAAAGATCGCATCCAATTAGCCAATATTATGCGTAAACTTCGTATCATGCCTGATGTATTACGTGTCAGCCGTAATAAAAACTAATTATGAATCCAACACGCTATGCCCGCATCTGCCAAATGATGGCGATGCGG