Homologs in group_346

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7 homologs were identified in 6 genomes with OrthoFinder.
The following table displays the locus tag of each homolog, the organism to which it belongs, the gene name and product.

Locus tag Identity Source Gene Product
EHELCC_14255 EHELCC_14255 100.0 Morganella morganii S2 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
NLDBIP_15350 NLDBIP_15350 100.0 Morganella morganii S4 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
LHKJJB_15260 LHKJJB_15260 100.0 Morganella morganii S3 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
HKOGLL_14380 HKOGLL_14380 100.0 Morganella morganii S5 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
F4V73_RS14595 F4V73_RS14595 96.3 Morganella psychrotolerans spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
F4V73_RS17820 F4V73_RS17820 37.1 Morganella psychrotolerans - HD domain-containing protein
PMI_RS14155 PMI_RS14155 89.1 Proteus mirabilis HI4320 spoT bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase

Distribution of the homologs in the orthogroup group_346

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Number of homologs in each genome (first column) and amino-acid identity of the closest homolog (second column).

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Phylogeny of the RefSeq best hits of group_346

Swissprot accession Eval Score ID (%) N gaps Alignment length Annot score Gene Description Organism
P0AG26 0.0 1281 87 1 702 3 spoT Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase Shigella flexneri
P0AG24 0.0 1281 87 1 702 1 spoT Bifunctional (p)ppGpp synthase/hydrolase SpoT Escherichia coli (strain K12)
P0AG25 0.0 1281 87 1 702 3 spoT Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase Escherichia coli O157:H7
Q9KNM2 0.0 1080 72 3 706 1 spoT Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
P43811 0.0 795 56 6 680 3 spoT Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
O54408 0.0 559 39 8 719 1 relA GTP pyrophosphokinase Bacillus subtilis (strain 168)
Q54089 0.0 559 41 9 719 1 relA Bifunctional (p)ppGpp synthase/hydrolase RelA Streptococcus dysgalactiae subsp. equisimilis
O52177 0.0 550 40 9 734 3 relA GTP pyrophosphokinase Myxococcus xanthus
Q6GG70 0.0 546 39 9 726 3 relA GTP pyrophosphokinase Staphylococcus aureus (strain MRSA252)
Q931Q4 0.0 546 39 9 726 1 relA GTP pyrophosphokinase Staphylococcus aureus (strain Mu50 / ATCC 700699)
P0A0E9 0.0 546 39 9 726 3 relA GTP pyrophosphokinase Staphylococcus aureus (strain MW2)
P0A0F0 0.0 546 39 9 726 3 relA GTP pyrophosphokinase Staphylococcus aureus
Q6G8T5 0.0 546 39 9 726 3 relA GTP pyrophosphokinase Staphylococcus aureus (strain MSSA476)
Q99TL8 0.0 546 39 9 726 1 relA GTP pyrophosphokinase Staphylococcus aureus (strain N315)
P74007 0.0 540 40 6 706 3 spoT Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
P52560 0.0 540 40 11 748 3 relA GTP pyrophosphokinase Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
O87331 1.05e-176 526 39 9 728 3 relA GTP pyrophosphokinase Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534)
P9WHG9 3.52e-175 521 39 8 728 1 relA Bifunctional (p)ppGpp synthase/hydrolase RelA Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WHG8 3.52e-175 521 39 8 728 3 relA Bifunctional (p)ppGpp synthase/hydrolase RelA Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Q8CS97 3.73e-175 521 39 10 717 3 relA GTP pyrophosphokinase Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)
Q5HNR8 3.73e-175 521 39 10 717 3 relA GTP pyrophosphokinase Staphylococcus epidermidis (strain ATCC 35984 / DSM 28319 / BCRC 17069 / CCUG 31568 / BM 3577 / RP62A)
P66015 9.11e-175 522 39 8 728 3 relA Probable GTP pyrophosphokinase Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Q49640 1.81e-172 516 39 9 729 3 relA Probable GTP pyrophosphokinase Mycobacterium leprae (strain TN)
O67012 5.45e-172 511 40 12 682 3 spoT Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase Aquifex aeolicus (strain VF5)
O85709 6.83e-169 508 39 9 740 3 relA GTP pyrophosphokinase Streptomyces antibioticus
Q8YG65 8.89e-164 492 39 6 693 1 rsh GTP pyrophosphokinase rsh Brucella melitensis biotype 1 (strain ATCC 23456 / CCUG 17765 / NCTC 10094 / 16M)
A5VPI9 1.81e-163 491 39 6 693 3 rsh GTP pyrophosphokinase rsh Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)
Q57E90 1.93e-163 491 39 6 693 1 rsh GTP pyrophosphokinase rsh Brucella abortus biovar 1 (strain 9-941)
Q2YN11 1.93e-163 491 39 6 693 3 rsh GTP pyrophosphokinase rsh Brucella abortus (strain 2308)
Q8CY42 2.79e-162 488 39 6 699 1 rsh GTP pyrophosphokinase rsh Brucella suis biovar 1 (strain 1330)
O34098 1.45e-146 448 35 15 728 3 spoT Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase Spiroplasma citri
P44644 4.72e-128 400 33 13 681 3 relA GTP pyrophosphokinase Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
P55133 1.39e-122 385 31 9 681 3 relA GTP pyrophosphokinase Photobacterium angustum (strain S14 / CCUG 15956)
O51216 5.95e-122 381 35 10 598 3 spoT Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)
P0AG23 3.71e-121 382 32 12 683 3 relA GTP pyrophosphokinase Shigella flexneri
P0AG20 3.71e-121 382 32 12 683 1 relA GTP pyrophosphokinase Escherichia coli (strain K12)
P0AG21 3.71e-121 382 32 12 683 3 relA GTP pyrophosphokinase Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
P0AG22 3.71e-121 382 32 12 683 3 relA GTP pyrophosphokinase Escherichia coli O157:H7
P0DKG8 1.17e-93 313 37 15 534 1 RSH1 Putative GTP diphosphokinase RSH1, chloroplastic Arabidopsis thaliana
Q9AYT5 1.87e-93 312 37 12 539 2 RSH1 Putative GTP diphosphokinase RSH1, chloroplastic Oryza sativa subsp. japonica
F4JHA2 5.81e-92 308 38 18 538 1 RSH1 Putative GTP diphosphokinase RSH1, chloroplastic Arabidopsis thaliana
Q9LVJ3 7.43e-80 271 44 5 345 2 RSH2 Probable GTP diphosphokinase RSH2, chloroplastic Arabidopsis thaliana
Q9M5P5 2.43e-79 270 41 8 383 2 RSH3 Probable GTP diphosphokinase RSH3, chloroplastic Arabidopsis thaliana
Q9SYH1 5.65e-79 270 41 8 386 2 RSH3 Probable GTP diphosphokinase RSH3, chloroplastic Arabidopsis thaliana
Q9M5P6 3.54e-78 267 44 5 345 2 RSH2 Probable GTP diphosphokinase RSH2, chloroplastic Arabidopsis thaliana
Q67UU0 9.95e-72 249 43 5 330 2 RSH3 Probable GTP diphosphokinase RSH3, chloroplastic Oryza sativa subsp. japonica
Q7XAP4 7.74e-70 245 42 6 348 2 RSH2 Probable GTP diphosphokinase RSH2, chloroplastic Oryza sativa subsp. japonica
P47520 1.74e-62 224 27 20 648 3 spoT Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
P75386 3.15e-57 210 34 4 355 3 spoT Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)
Q84R11 4.59e-34 141 28 7 328 2 CRSH Probable GTP diphosphokinase CRSH, chloroplastic Arabidopsis thaliana
Q75IS2 2.68e-32 135 28 8 329 1 CRSH3 GTP diphosphokinase CRSH3, chloroplastic Oryza sativa subsp. japonica
Q6ATB2 2.02e-29 127 29 11 346 1 CRSH2 GTP diphosphokinase CRSH2, chloroplastic Oryza sativa subsp. japonica
Q6ATB4 2.49e-28 124 29 7 307 1 CRSH1 GTP diphosphokinase CRSH1, chloroplastic Oryza sativa subsp. japonica
Q4UMH6 7.09e-19 95 26 7 300 4 RF_0381 Putative ankyrin repeat protein RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)
Q568P1 2.92e-16 80 41 3 115 2 hddc3 Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 Danio rerio
Q9VAM9 6.78e-16 79 42 3 118 1 Mesh1 Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 Drosophila melanogaster
Q28C98 4.49e-13 71 37 3 136 2 hddc3 Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 Xenopus tropicalis
Q8N4P3 3.77e-12 68 37 4 140 1 HDDC3 Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 Homo sapiens
Q9D114 2.51e-11 66 37 3 134 1 Hddc3 Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 Mus musculus
P29941 1.05e-10 64 34 3 138 4 None Uncharacterized 19.2 kDa protein in cobO 3'region Sinorhizobium sp.
P39583 6.98e-06 51 37 3 102 1 ywaC GTP pyrophosphokinase YwaC Bacillus subtilis (strain 168)

  • Number of RefSeq hits:

General

Source Morganella morganii S1
Locus tag FBDBKF_12050
Feature type CDS
Gene spoT
Product bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase
Location 59907 - 62012 (strand: 1)
Length 2106 (nucleotides) / 701 (amino acids)

Contig

Accession contig_14
Length 134564 nucleotides
Topology linear
Plasmid False

Orthology

Orthogroup group_346
Orthogroup size 8
N. genomes 7

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Genomic region

Domains

PF02824 TGS domain
PF04607 Region found in RelA / SpoT proteins
PF13291 ACT domain
PF13328 HD domain
PF19296 RelA/SpoT, AH and RIS domains

COG entry Annotation(s)

ID Function(s) descr. Function(s) cat. Description
COG0317 Signal transduction mechanisms (T)
Transcription (K)		 TK (p)ppGpp synthase/hydrolase, HD superfamily

Kegg Ortholog Annotation(s)

KO Description Pathways Modules
K01139 GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2] Purine metabolism
Metabolic pathways		 -

Protein Sequence

MYLFESLNHIVKDYLPKEQIDLLKQAYVVARDAHEGQTRSSGEPYITHPVAVACILAEMRLDLETLMAALLHDVIEDTPATFQDIEQLFGTTVAGLVEGVSKLDKLNFRDKKEAQAENFRKMVMAMVKDIRVILIKLADRTHNMRTLGSLRPDKRRRIARETLEIYSPLAHRLGIHHIKTELEELGFEALYPNRYRVIKEVVKAARGNRKEMIQKILSEIEGRLTEAGISCKVSGREKHLYSIYRKMHLKEQRFHSIMDIYAFRVIVSTVDTCYRVLGQVHGLYKPRPGRVKDYIAIPKANGYQSLHTSLIGPHGVPVEVQIRTEDMDQMAEMGVAAHWAYKEHGESGTTAQVRAHRWMQSLIELQQSTGNTFEFIESVKSDLFPDEIYVFTPEGRIVELPTGATPVDFAYAVHTDIGHSCVGARVDRQPYPLSQQLTSGQTVEIITAPGARPNAAWLNFVVSSKARAKIRQLLKNLKRDDSVNLGRRLLNHALGNGRKITDIPQENISRELVRMKLATLDDLLAEIGLGNAMSVVVARNLLNEPESNTEESTTRKLPIKGADGVLITFAKCCRPVPGDPIIAHISPGKGLVIHHESCRNIRGYEKEPEKFMAVEWDNDIDTDFIAEIKVDMFNHQGALANLTAAINDANSSIQSMNTEEKDGRVYCAFIRLTAKDRIQLANIMRKIRIMPDVLRVSRNRN

Flanking regions ( +/- flanking 50bp)

GCGGTTTCTGCAATCGCCGAAGGACGTCGTTAAGTTAAGGTAGGTCTGCCTTGTACCTGTTTGAAAGCCTGAACCATATTGTTAAGGATTATCTGCCGAAAGAGCAGATTGATCTGTTAAAACAAGCCTATGTCGTTGCGCGGGATGCTCACGAAGGGCAGACCCGCTCCAGTGGCGAACCGTATATTACCCATCCGGTCGCTGTTGCCTGTATCCTGGCCGAGATGCGTCTCGACCTCGAAACACTGATGGCAGCACTGCTGCACGACGTTATTGAAGATACGCCTGCCACCTTTCAGGATATTGAACAACTGTTCGGCACCACTGTTGCCGGGCTGGTGGAAGGGGTATCGAAGTTAGACAAACTGAACTTCCGCGATAAAAAAGAAGCTCAGGCTGAAAACTTCCGCAAAATGGTCATGGCGATGGTGAAAGACATCCGTGTCATTCTCATCAAGCTGGCAGACCGCACGCACAACATGCGCACGCTCGGGTCTCTGCGTCCCGATAAGCGTCGCCGTATTGCGCGCGAAACCCTTGAAATCTACAGTCCTCTGGCTCACCGTCTCGGTATTCACCATATCAAAACGGAGCTTGAGGAGCTGGGATTCGAAGCCCTTTACCCGAACCGCTACCGCGTCATCAAAGAAGTGGTGAAAGCCGCGCGCGGCAACCGTAAAGAGATGATCCAGAAGATTTTATCCGAAATCGAAGGACGTCTGACGGAAGCCGGGATCAGCTGCAAAGTCAGCGGACGGGAAAAACATCTCTACTCCATCTACCGGAAAATGCACCTGAAAGAGCAGCGTTTTCACTCGATCATGGACATTTATGCATTCCGCGTGATTGTAAGCACTGTCGACACCTGTTACCGCGTATTAGGTCAGGTTCACGGCCTGTACAAACCGCGTCCCGGCCGCGTCAAAGATTATATCGCCATCCCGAAAGCCAACGGCTATCAGTCATTACACACCTCCCTTATCGGCCCTCACGGGGTGCCGGTGGAAGTGCAGATCCGGACCGAAGATATGGATCAGATGGCGGAAATGGGGGTGGCTGCACACTGGGCTTATAAAGAGCACGGTGAATCCGGCACCACCGCACAGGTGCGTGCCCACCGCTGGATGCAGAGCCTGATAGAACTTCAGCAAAGCACCGGCAACACCTTTGAATTTATTGAGAGCGTGAAATCCGATCTCTTCCCGGATGAGATTTATGTCTTCACGCCGGAAGGCCGGATTGTGGAACTGCCGACCGGCGCCACTCCGGTGGATTTCGCCTATGCCGTGCATACGGACATCGGCCACTCCTGTGTCGGCGCGCGCGTTGACCGCCAGCCGTATCCGCTCTCCCAGCAACTGACCAGCGGACAAACCGTTGAAATTATTACCGCGCCGGGCGCACGGCCGAATGCCGCGTGGCTGAACTTTGTTGTCAGCTCAAAAGCCCGGGCGAAAATCCGTCAGTTACTGAAAAACCTCAAAAGGGATGATTCTGTCAACCTGGGCCGTCGTCTGCTCAACCATGCACTCGGTAACGGCCGTAAGATCACAGATATCCCTCAGGAAAATATCAGCCGTGAGCTGGTGCGGATGAAACTGGCGACTCTGGATGACCTGCTGGCGGAAATCGGCCTGGGGAATGCCATGAGTGTGGTGGTTGCCCGTAACCTGCTGAACGAGCCGGAAAGTAATACCGAAGAGAGTACCACCCGCAAGCTGCCGATCAAAGGCGCGGACGGGGTGCTTATCACCTTCGCCAAATGCTGCCGGCCGGTACCGGGTGACCCGATTATCGCCCATATCAGTCCGGGTAAAGGGCTGGTTATCCACCATGAATCCTGCCGTAATATCCGCGGATATGAAAAAGAGCCGGAAAAATTCATGGCCGTTGAGTGGGATAATGACATCGACACGGATTTTATTGCTGAAATCAAAGTGGATATGTTTAACCACCAGGGCGCGCTGGCTAACCTGACTGCCGCAATTAATGATGCCAACTCCAGTATTCAGAGCATGAATACCGAGGAGAAAGATGGCCGCGTTTACTGCGCCTTTATCCGCCTGACCGCAAAAGACCGTATCCAGCTTGCGAATATTATGCGTAAGATCCGCATTATGCCGGATGTCCTGCGCGTCAGCCGTAACCGGAATTAATCACACGGTATGAATTCCCAACGTTATGAGCGCATCTGCCGGATGATGGC