VFG038380


Help to interpret the results

Three outputs have been generated:
General: this tab contains the description, occurence in the database and other information related to the selected Virulence factor VFG038380
Protein list: lists the 7 occurences of the Virulence factor within the database. The table reports information on each occurence.
Profile: phylogenetic tree annotated with
- the presence of the Virulence factor of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Virulence factor has been clustered.
Orthogroups are shown in red if they are annotated with that particular Virulence factor in a given genome , in green otherwise, i.e. if there is a discrepency between orthogroup clustering and Virulence factor prediction.
Green homologs (same orthogroup) are not positive hit(s) for the considered Virulence factor.
Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Virulence factor prediction.

Description

Protein Type VI secretion system contractile sheath large subunit TssC/VipB
VF ID VF0480
Category Effector delivery system
Protein ID WP_043163044
Function A phagetail-spike-like injectisome to translocate virulence determinants directly into the host cell cytoplasm; Four effectors of the T6SS have so far been characterized, Hcp1, Vgr1, Vgr2 and Vgr3; Hcp is a powerful effector substrate and once translocated into the targeted host cell cytoplasm, apoptosis ensues following caspase 3 activation; Hcp paralyzes macrophages to prevent phagocytosis;Vgr1 is an ADP-ribosylating toxin capable of interrupting the host cell cytoskeleton and inducing apoptosis
Vf_category_id VFC0086

Occurence in the database

VFG038380 is associated with 7 different proteins
The 7 proteins are classified into 1 different orthogroup(s)
Orthogroup Locus Start Stop S. Gene Product Organism
0 group_77 FBDBKF_01295 249645 251129 1 tssC type VI secretion system contractile sheath large subunit Morganella morganii S1
1 group_77 EHELCC_00250 57739 59223 -1 tssC type VI secretion system contractile sheath large subunit Morganella morganii S2
2 group_77 NLDBIP_03210 620913 622397 1 tssC type VI secretion system contractile sheath large subunit Morganella morganii S4
3 group_77 LHKJJB_04725 228154 229638 1 tssC type VI secretion system contractile sheath large subunit Morganella morganii S3
4 group_77 HKOGLL_02320 57944 59428 -1 tssC type VI secretion system contractile sheath large subunit Morganella morganii S5
5 group_77 F4V73_RS02375 504889 506373 -1 tssC type VI secretion system contractile sheath large subunit Morganella psychrotolerans
6 group_77 PMI_RS03680 827814 829292 -1 tssC type VI secretion system contractile sheath large subunit Proteus mirabilis HI4320