VFG038380


Help to interpret the results

Three outputs have been generated:
General: this result contains the description and frequency of the selected Virulence factors VFG038380, of which KO pathways and KO modules it is part. Additionally, its occurence in the database is reported.
Proteins list: list of occurences of the Virulence factors within the database. 7 occurences are identified. The table reports the orthogroup, the organism in which each occurrence has been found, and the locus tag enriched by start and stop position, strand, gene name and product.
Clicking on the Ortohgroup name or locus you will be redirected to further info.
Profiles: Phylogenetic tree annotated with
- the presence of the Virulence factor(s) of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Virulence factors has been clustered.
In red the Virulence factors with positive hit(s) in the corresponding genome.
In green the discrepencies between orthogroup clustering and Virulence factors prediction. Green homologs (same orthogroup) are not positive hit(s) for the considered Virulence factors.

Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Virulence factors prediction.

Description

Protein Type VI secretion system contractile sheath large subunit TssC/VipB
VF ID VF0480
Category Effector delivery system
Protein ID WP_043163044
Function A phagetail-spike-like injectisome to translocate virulence determinants directly into the host cell cytoplasm; Four effectors of the T6SS have so far been characterized, Hcp1, Vgr1, Vgr2 and Vgr3; Hcp is a powerful effector substrate and once translocated into the targeted host cell cytoplasm, apoptosis ensues following caspase 3 activation; Hcp paralyzes macrophages to prevent phagocytosis;Vgr1 is an ADP-ribosylating toxin capable of interrupting the host cell cytoskeleton and inducing apoptosis
Vf_category_id VFC0086

Occurence in the database

VFG038380 is associated with 7 different proteins (see tab "Protein list" and "Profile")
The 7 proteins are classified into 1 different orthogroup(s)
# Orthogroup Locus Start Stop S. Gene Product Organism
0 group_545 FBDBKF_01295 249645 251129 1 tssC type VI secretion system contractile sheath large subunit Morganella morganii S1
1 group_545 EHELCC_00250 57739 59223 -1 tssC type VI secretion system contractile sheath large subunit Morganella morganii S2
2 group_545 NLDBIP_03210 620913 622397 1 tssC type VI secretion system contractile sheath large subunit Morganella morganii S4
3 group_545 LHKJJB_04725 228154 229638 1 tssC type VI secretion system contractile sheath large subunit Morganella morganii S3
4 group_545 HKOGLL_02320 57944 59428 -1 tssC type VI secretion system contractile sheath large subunit Morganella morganii S5
5 group_545 F4V73_RS02375 504889 506373 -1 tssC type VI secretion system contractile sheath large subunit Morganella psychrotolerans
6 group_545 PMI_RS03680 827814 829292 -1 tssC type VI secretion system contractile sheath large subunit Proteus mirabilis HI4320