VFG038370


Help to interpret the results

Three outputs have been generated:
General: this tab contains the description, occurence in the database and other information related to the selected Virulence factor VFG038370
Protein list: lists the 4 occurences of the Virulence factor within the database. The table reports information on each occurence.
Profile: phylogenetic tree annotated with
- the presence of the Virulence factor of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Virulence factor has been clustered.
Orthogroups are shown in red if they are annotated with that particular Virulence factor in a given genome , in green otherwise, i.e. if there is a discrepency between orthogroup clustering and Virulence factor prediction.
Green homologs (same orthogroup) are not positive hit(s) for the considered Virulence factor.
Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Virulence factor prediction.

Description

Protein hemolysin co-regulated protein
VF ID VF0480
Category Effector delivery system
Protein ID WP_010634822
Function A phagetail-spike-like injectisome to translocate virulence determinants directly into the host cell cytoplasm; Four effectors of the T6SS have so far been characterized, Hcp1, Vgr1, Vgr2 and Vgr3; Hcp is a powerful effector substrate and once translocated into the targeted host cell cytoplasm, apoptosis ensues following caspase 3 activation; Hcp paralyzes macrophages to prevent phagocytosis;Vgr1 is an ADP-ribosylating toxin capable of interrupting the host cell cytoskeleton and inducing apoptosis
Vf_category_id VFC0086

Occurence in the database

VFG038370 is associated with 4 different proteins
The 4 proteins are classified into 1 different orthogroup(s)
Orthogroup Locus Start Stop S. Gene Product Organism
0 group_126 PMI_RS00995 245183 245701 1 Hcp family type VI secretion system effector Proteus mirabilis HI4320
1 group_126 PMI_RS03690 831710 832228 1 Hcp family type VI secretion system effector Proteus mirabilis HI4320
2 group_126 PMI_RS05420 1185979 1186497 1 Hcp family type VI secretion system effector Proteus mirabilis HI4320
3 group_126 PMI_RS14785 3278930 3279448 1 Hcp family type VI secretion system effector Proteus mirabilis HI4320