VFG038370


Help to interpret the results

Three outputs have been generated:
General: this result contains the description and frequency of the selected Virulence factors VFG038370, of which KO pathways and KO modules it is part. Additionally, its occurence in the database is reported.
Proteins list: list of occurences of the Virulence factors within the database. 4 occurences are identified. The table reports the orthogroup, the organism in which each occurrence has been found, and the locus tag enriched by start and stop position, strand, gene name and product.
Clicking on the Ortohgroup name or locus you will be redirected to further info.
Profiles: Phylogenetic tree annotated with
- the presence of the Virulence factor(s) of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Virulence factors has been clustered.
In red the Virulence factors with positive hit(s) in the corresponding genome.
In green the discrepencies between orthogroup clustering and Virulence factors prediction. Green homologs (same orthogroup) are not positive hit(s) for the considered Virulence factors.

Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Virulence factors prediction.

Description

Protein hemolysin co-regulated protein
VF ID VF0480
Category Effector delivery system
Protein ID WP_010634822
Function A phagetail-spike-like injectisome to translocate virulence determinants directly into the host cell cytoplasm; Four effectors of the T6SS have so far been characterized, Hcp1, Vgr1, Vgr2 and Vgr3; Hcp is a powerful effector substrate and once translocated into the targeted host cell cytoplasm, apoptosis ensues following caspase 3 activation; Hcp paralyzes macrophages to prevent phagocytosis;Vgr1 is an ADP-ribosylating toxin capable of interrupting the host cell cytoskeleton and inducing apoptosis
Vf_category_id VFC0086

Occurence in the database

VFG038370 is associated with 4 different proteins (see tab "Protein list" and "Profile")
The 4 proteins are classified into 1 different orthogroup(s)
# Orthogroup Locus Start Stop S. Gene Product Organism
0 group_168 PMI_RS00995 245183 245701 1 Hcp family type VI secretion system effector Proteus mirabilis HI4320
1 group_168 PMI_RS03690 831710 832228 1 Hcp family type VI secretion system effector Proteus mirabilis HI4320
2 group_168 PMI_RS05420 1185979 1186497 1 Hcp family type VI secretion system effector Proteus mirabilis HI4320
3 group_168 PMI_RS14785 3278930 3279448 1 Hcp family type VI secretion system effector Proteus mirabilis HI4320