VFG018246
Help to interpret the results
Three outputs have been generated:
General: this tab contains the description, occurence in the database and other information related to the selected Virulence factor VFG018246
Protein list: lists the 1 occurences of the Virulence factor within the database. The table reports information on each occurence.
Profile: phylogenetic tree annotated with
- the presence of the Virulence factor of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Virulence factor has been clustered.
Orthogroups are shown in red if they are annotated with that particular Virulence factor in a given genome , in green otherwise, i.e. if there is a discrepency between orthogroup clustering and Virulence factor prediction.
Green homologs (same orthogroup) are not positive hit(s) for the considered Virulence factor.
Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Virulence factor prediction.
Description
| Protein |
S-ribosylhomocysteinase |
| VF ID |
VF0406 |
| Category |
Biofilm |
| Protein ID |
WP_011261308 |
| Characteristics |
AI-2 is produced and detected by a wide variety of bacteria and is presumed to facilitate interspecies communications. |
| Structure |
Furanosyl borate diester (2S,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran borate |
| Function |
LuxPQ receptor complex responds to the AI-2 molecule. Information from AI-2 is transduced through the LuxO protein to control the levels of the master transcription factor HapR. At low cell density, in the absence of autoinducers, HapR is not produced, so virulence factors are expressed and biofilms are formed. At high cell density, in the presence of autoinducers, LuxO is inactivated, HapR is produced, and it represses genes for virulence factor production and biofilm formation. These events are proposed to allow V. cholerae to leave the host, re-enter the environment in large numbers and initiate a new cycle of infection. |
| Vf_category_id |
VFC0271 |
Occurence in the database
| VFG018246 is associated with 1 different
proteins
|
|
The 1 proteins are classified into 1 different orthogroup(s)
|
|
Orthogroup |
Locus |
Start |
Stop |
S. |
Gene |
Product |
Organism |
| 0 |
group_2077 |
F4V73_RS12165 |
17842 |
18357 |
-1 |
luxS |
S-ribosylhomocysteine lyase |
Morganella psychrotolerans |
