VFG002454
Help to interpret the results
Three outputs have been generated:
General: this tab contains the description, occurence in the database and other information related to the selected Virulence factor VFG002454
Protein list: lists the 1 occurences of the Virulence factor within the database. The table reports information on each occurence.
Profile: phylogenetic tree annotated with
- the presence of the Virulence factor of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Virulence factor has been clustered.
Orthogroups are shown in red if they are annotated with that particular Virulence factor in a given genome , in green otherwise, i.e. if there is a discrepency between orthogroup clustering and Virulence factor prediction.
Green homologs (same orthogroup) are not positive hit(s) for the considered Virulence factor.
Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Virulence factor prediction.
Description
| Protein |
Type III secretion system protein BsaX |
| VF ID |
VF0428 |
| Category |
Effector delivery system |
| Protein ID |
WP_004187417 |
| Characteristics |
Mxi-SpaA like T3SS, shares homology to Salmonella SPI-1 and Shigella T3SSs; Two additional T3SSs are discovered in B. Pseudomallei. T3SS1 is only present in B. pseudomallei and not in Burkholderia mallei or Burkholderia thailandensis, whereas T3SS2 and T3SS3 (Bsa) are present in all three species. T3SS1 and T3SS2 are closely related to the T3SS of the plant pathogens R. solanacearum and Xanthomonas spp. T3SS1 and T3SS2 are required during B. pseudomallei infection of tomato plants but not for infection of hamsters. |
| Function |
Delivering effector proteins into host cells to manipulate host cell functions |
| Mechanism |
Three effectors: BopE, homolog of SopE and SopE2 of Salmonella, functions as GTPase involving bacterial invasion. BopA, homolog of IcsB of Shigella, suppresses autophagy. BopC, function unkown. |
| Vf_category_id |
VFC0086 |
Occurence in the database
| VFG002454 is associated with 1 different
proteins
|
|
The 1 proteins are classified into 1 different orthogroup(s)
|
|
Orthogroup |
Locus |
Start |
Stop |
S. |
Gene |
Product |
Organism |
| 0 |
group_286 |
PMI_RS13240 |
2939621 |
2939869 |
-1 |
sctS |
type III secretion system export apparatus subunit SctS |
Proteus mirabilis HI4320 |
