VFG000121

Help to interpret the results

Three outputs have been generated:
General: this tab contains the description, occurence in the database and other information related to the selected Virulence factor VFG000121
Protein list: lists the 7 occurences of the Virulence factor within the database. The table reports information on each occurence.
Profile: phylogenetic tree annotated with
- the presence of the Virulence factor of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Virulence factor has been clustered.
Orthogroups are shown in red if they are annotated with that particular Virulence factor in a given genome , in green otherwise, i.e. if there is a discrepency between orthogroup clustering and Virulence factor prediction.
Green homologs (same orthogroup) are not positive hit(s) for the considered Virulence factor.
Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Virulence factor prediction.

Description

Protein alginate biosynthesis protein AlgZ/FimS
VF ID VF0091
Category Biofilm
Protein ID NP_249453
Characteristics Alginate production is frequently referred to as mucoidy because colonies producing alginate have a wet glistening (mucoid) appearance, which is very different from that of colonies not producing alginate; most of the alginate biosynthetic genes are clustered in the algD operon; Alginate production is highly regulated. Regulatory genes are located in two areas far removed from the biosynthetic genes, with one exception algC
Structure Alginate is a linear polymer of high molecular weight composed of the uronic acids beta-D-mannuronate and its C-5 epimer, alpha-L-guluronate, which are linked by beta-1,4 glycosidic bonds; The early steps in the biosynthesis of alginate to form GDP mannuronic acid require the products of algA and algC to convert fructose-6-phosphate to GDP-mannose and then require the product of algD to convert this to the uronic acid form, GDP-mannuronate
Function Allows the bacteria form biofilm; contributes to the persistence of the bacteria in the CF lung: act as an adhesin, preventing the bacteria from being expelled from the lung, and alginate slime layer makes it more difficult for phagocytes to ingest and kill the bacteria
Vf_category_id VFC0271

Occurence in the database

VFG000121 is associated with 7 different proteins
The 7 proteins are classified into 1 different orthogroup(s)
Orthogroup Locus Start Stop S. Gene Product Organism
0 group_639 FBDBKF_01460 290673 291251 -1 rpoE RNA polymerase sigma factor RpoE Morganella morganii S1
1 group_639 EHELCC_00085 17617 18195 1 rpoE RNA polymerase sigma factor RpoE Morganella morganii S2
2 group_639 NLDBIP_03375 661941 662519 -1 rpoE RNA polymerase sigma factor RpoE Morganella morganii S4
3 group_639 LHKJJB_04890 269182 269760 -1 rpoE RNA polymerase sigma factor RpoE Morganella morganii S3
4 group_639 HKOGLL_02155 17822 18400 1 rpoE RNA polymerase sigma factor RpoE Morganella morganii S5
5 group_639 F4V73_RS01945 425400 425975 1 rpoE RNA polymerase sigma factor RpoE Morganella psychrotolerans
6 group_639 PMI_RS09350 2040616 2041194 -1 rpoE RNA polymerase sigma factor RpoE Proteus mirabilis HI4320