VFG000121
Help to interpret the results
Three outputs have been generated:
General: this result contains the description and frequency of the selected Virulence factors VFG000121, of which KO pathways and KO modules it is part. Additionally, its occurence in the database is reported.
Proteins list: list of occurences of the Virulence factors
within the database. 7 occurences are identified.
The table reports the orthogroup, the organism in which each occurrence has been found, and the locus tag enriched by start and stop position, strand, gene name and product.
Clicking on the Ortohgroup name or locus you will be redirected to further info.
Profiles: Phylogenetic tree annotated with
- the presence of the Virulence factor(s) of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Virulence factors has been clustered.
In red the Virulence factors with positive hit(s) in the corresponding genome.
In green the discrepencies between orthogroup clustering and Virulence factors prediction.
Green homologs (same orthogroup) are not positive hit(s) for the considered Virulence factors.
Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Virulence factors prediction.
Description
Protein |
alginate biosynthesis protein AlgZ/FimS |
VF ID |
VF0091 |
Category |
Biofilm |
Protein ID |
NP_249453 |
Characteristics |
Alginate production is frequently referred to as mucoidy because colonies producing alginate have a wet glistening (mucoid) appearance, which is very different from that of colonies not producing alginate; most of the alginate biosynthetic genes are clustered in the algD operon; Alginate production is highly regulated. Regulatory genes are located in two areas far removed from the biosynthetic genes, with one exception algC |
Structure |
Alginate is a linear polymer of high molecular weight composed of the uronic acids beta-D-mannuronate and its C-5 epimer, alpha-L-guluronate, which are linked by beta-1,4 glycosidic bonds; The early steps in the biosynthesis of alginate to form GDP mannuronic acid require the products of algA and algC to convert fructose-6-phosphate to GDP-mannose and then require the product of algD to convert this to the uronic acid form, GDP-mannuronate |
Function |
Allows the bacteria form biofilm; contributes to the persistence of the bacteria in the CF lung: act as an adhesin, preventing the bacteria from being expelled from the lung, and alginate slime layer makes it more difficult for phagocytes to ingest and kill the bacteria |
Vf_category_id |
VFC0271 |
Occurence in the database
VFG000121 is associated with 7 different proteins (see tab "Protein list" and "Profile") |
The 7 proteins are classified into 1 different orthogroup(s)
|
# |
Orthogroup |
Locus |
Start |
Stop |
S. |
Gene |
Product |
Organism |
0 |
group_565 |
FBDBKF_01460 |
290673 |
291251 |
-1 |
rpoE |
RNA polymerase sigma factor RpoE |
Morganella morganii S1 |
1 |
group_565 |
EHELCC_00085 |
17617 |
18195 |
1 |
rpoE |
RNA polymerase sigma factor RpoE |
Morganella morganii S2 |
2 |
group_565 |
NLDBIP_03375 |
661941 |
662519 |
-1 |
rpoE |
RNA polymerase sigma factor RpoE |
Morganella morganii S4 |
3 |
group_565 |
LHKJJB_04890 |
269182 |
269760 |
-1 |
rpoE |
RNA polymerase sigma factor RpoE |
Morganella morganii S3 |
4 |
group_565 |
HKOGLL_02155 |
17822 |
18400 |
1 |
rpoE |
RNA polymerase sigma factor RpoE |
Morganella morganii S5 |
5 |
group_565 |
F4V73_RS01945 |
425400 |
425975 |
1 |
rpoE |
RNA polymerase sigma factor RpoE |
Morganella psychrotolerans |
6 |
group_565 |
PMI_RS09350 |
2040616 |
2041194 |
-1 |
rpoE |
RNA polymerase sigma factor RpoE |
Proteus mirabilis HI4320 |