K12524


Help to interpret the results

Three outputs have been generated:
General: this result contains the description and frequency of the selected Kegg Orthologs K12524, of which KO pathways and KO modules it is part. Additionally, its occurence in the database is reported.
Proteins list: list of occurences of the Kegg Orthologs within the database. 7 occurences are identified. The table reports the orthogroup, the organism in which each occurrence has been found, and the locus tag enriched by start and stop position, strand, gene name and product.
Clicking on the Ortohgroup name or locus you will be redirected to further info.
Profiles: Phylogenetic tree annotated with
- the presence of the Kegg Ortholog(s) of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Kegg Orthologs has been clustered.
In red the Kegg Orthologs with positive hit(s) in the corresponding genome.
In green the discrepencies between orthogroup clustering and Kegg Orthologs prediction. Green homologs (same orthogroup) are not positive hit(s) for the considered Kegg Orthologs.

Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Kegg Orthologs prediction.

Description

External link K12524
KO K12524
Description bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:2.7.2.4 1.1.1.3]

KO part of 8 pathways

Glycine, serine and threonine metabolism
Monobactam biosynthesis
Cysteine and methionine metabolism
Lysine biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Biosynthesis of amino acids

KO part of 5 modules

M00016 Lysine metabolism Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
M00017 Cysteine and methionine metabolism Methionine biosynthesis, aspartate => homoserine => methionine
M00018 Serine and threonine metabolism Threonine biosynthesis, aspartate => homoserine => threonine
M00526 Lysine metabolism Lysine biosynthesis, DAP dehydrogenase pathway, aspartate => lysine
M00527 Lysine metabolism Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine

Occurence in the database

K12524 is associated with 7 different proteins (see tab "Protein list" and "Profile")
The 7 proteins are classified into 1 different orthogroup(s)
# Orthogroup Locus Start Stop S. Gene Product Organism
0 group_1141 PMI_RS00005 337 2796 1 thrA bifunctional aspartate kinase/homoserine dehydrogenase I Proteus mirabilis HI4320
1 group_1141 FBDBKF_06530 145664 148123 -1 thrA bifunctional aspartate kinase/homoserine dehydrogenase I Morganella morganii S1
2 group_1141 EHELCC_09575 146236 148695 -1 thrA bifunctional aspartate kinase/homoserine dehydrogenase I Morganella morganii S2
3 group_1141 NLDBIP_09955 146236 148695 -1 thrA bifunctional aspartate kinase/homoserine dehydrogenase I Morganella morganii S4
4 group_1141 LHKJJB_07800 68543 71002 1 thrA bifunctional aspartate kinase/homoserine dehydrogenase I Morganella morganii S3
5 group_1141 HKOGLL_07350 68543 71002 1 thrA bifunctional aspartate kinase/homoserine dehydrogenase I Morganella morganii S5
6 group_1141 F4V73_RS15400 65446 67905 1 thrA bifunctional aspartate kinase/homoserine dehydrogenase I Morganella psychrotolerans