K00135


Help to interpret the results

Three outputs have been generated:
General: this result contains the description and frequency of the selected Kegg Orthologs K00135, of which KO pathways and KO modules it is part. Additionally, its occurence in the database is reported.
Proteins list: list of occurences of the Kegg Orthologs within the database. 7 occurences are identified. The table reports the orthogroup, the organism in which each occurrence has been found, and the locus tag enriched by start and stop position, strand, gene name and product.
Clicking on the Ortohgroup name or locus you will be redirected to further info.
Profiles: Phylogenetic tree annotated with
- the presence of the Kegg Ortholog(s) of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Kegg Orthologs has been clustered.
In red the Kegg Orthologs with positive hit(s) in the corresponding genome.
In green the discrepencies between orthogroup clustering and Kegg Orthologs prediction. Green homologs (same orthogroup) are not positive hit(s) for the considered Kegg Orthologs.

Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Kegg Orthologs prediction.

Description

External link K00135
KO K00135
Description succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20]

KO part of 7 pathways

Alanine, aspartate and glutamate metabolism
Lysine degradation
Tyrosine metabolism
Butanoate metabolism
Nicotinate and nicotinamide metabolism
Metabolic pathways
Microbial metabolism in diverse environments

KO part of 3 modules

M00027 Other amino acid metabolism GABA (gamma-Aminobutyrate) shunt
M00956 Lysine metabolism Lysine degradation, bacteria, L-lysine => succinate
M00957 Lysine metabolism Lysine degradation, bacteria, L-lysine => glutarate => succinate/acetyl-CoA

Occurence in the database

K00135 is associated with 7 different proteins (see tab "Protein list" and "Profile")
The 7 proteins are classified into 1 different orthogroup(s)
# Orthogroup Locus Start Stop S. Gene Product Organism
0 group_1848 PMI_RS16840 3708297 3709745 -1 NAD-dependent succinate-semialdehyde dehydrogenase Proteus mirabilis HI4320
1 group_1848 FBDBKF_13820 57272 58744 1 gabD Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase Morganella morganii S1
2 group_1848 EHELCC_11490 142148 143620 1 gabD Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase Morganella morganii S2
3 group_1848 NLDBIP_11835 142148 143620 1 gabD Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase Morganella morganii S4
4 group_1848 LHKJJB_11695 142148 143620 1 gabD Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase Morganella morganii S3
5 group_1848 HKOGLL_10305 142148 143620 1 gabD Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase Morganella morganii S5
6 group_1848 F4V73_RS12685 135749 137221 1 NAD-dependent succinate-semialdehyde dehydrogenase Morganella psychrotolerans