K00052


Help to interpret the results

Three outputs have been generated:
General: this tab contains the description, occurence in the database and other information related to the selected Kegg Ortholog K00052
Protein list: lists the 7 occurences of the Kegg Ortholog within the database. The table reports information on each occurence.
Profile: phylogenetic tree annotated with
- the presence of the Kegg Ortholog of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Kegg Ortholog has been clustered.
Orthogroups are shown in red if they are annotated with that particular Kegg Ortholog in a given genome , in green otherwise, i.e. if there is a discrepency between orthogroup clustering and Kegg Ortholog prediction.
Green homologs (same orthogroup) are not positive hit(s) for the considered Kegg Ortholog.
Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Kegg Ortholog prediction.

Description

External link K00052
KO K00052
Description 3-isopropylmalate dehydrogenase [EC:1.1.1.85]

KO part of 6 pathways

Valine, leucine and isoleucine biosynthesis
C5-Branched dibasic acid metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
2-Oxocarboxylic acid metabolism
Biosynthesis of amino acids

KO part of 2 modules

M00432 Branched-chain amino acid metabolism Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
M00535 Branched-chain amino acid metabolism Isoleucine biosynthesis, pyruvate => 2-oxobutanoate

Occurence in the database

K00052 is associated with 7 different proteins
The 7 proteins are classified into 1 different orthogroup(s)
Orthogroup Locus Start Stop S. Gene Product Organism
0 group_939 FBDBKF_04415 76270 77361 1 leuB 3-isopropylmalate dehydrogenase Morganella morganii S1
1 group_939 EHELCC_05705 135727 136818 1 leuB 3-isopropylmalate dehydrogenase Morganella morganii S2
2 group_939 NLDBIP_06025 176792 177883 1 leuB 3-isopropylmalate dehydrogenase Morganella morganii S4
3 group_939 LHKJJB_02905 154316 155407 1 leuB 3-isopropylmalate dehydrogenase Morganella morganii S3
4 group_939 HKOGLL_06380 76180 77271 1 leuB 3-isopropylmalate dehydrogenase Morganella morganii S5
5 group_939 F4V73_RS08860 1837377 1838492 1 leuB 3-isopropylmalate dehydrogenase Morganella psychrotolerans
6 group_939 PMI_RS10270 2251961 2253052 1 leuB 3-isopropylmalate dehydrogenase Proteus mirabilis HI4320