K00052


Help to interpret the results

Three outputs have been generated:
General: this result contains the description and frequency of the selected Kegg Orthologs K00052, of which KO pathways and KO modules it is part. Additionally, its occurence in the database is reported.
Proteins list: list of occurences of the Kegg Orthologs within the database. 7 occurences are identified. The table reports the orthogroup, the organism in which each occurrence has been found, and the locus tag enriched by start and stop position, strand, gene name and product.
Clicking on the Ortohgroup name or locus you will be redirected to further info.
Profiles: Phylogenetic tree annotated with
- the presence of the Kegg Ortholog(s) of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Kegg Orthologs has been clustered.
In red the Kegg Orthologs with positive hit(s) in the corresponding genome.
In green the discrepencies between orthogroup clustering and Kegg Orthologs prediction. Green homologs (same orthogroup) are not positive hit(s) for the considered Kegg Orthologs.

Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Kegg Orthologs prediction.

Description

External link K00052
KO K00052
Description 3-isopropylmalate dehydrogenase [EC:1.1.1.85]

KO part of 6 pathways

Valine, leucine and isoleucine biosynthesis
C5-Branched dibasic acid metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
2-Oxocarboxylic acid metabolism
Biosynthesis of amino acids

KO part of 2 modules

M00432 Branched-chain amino acid metabolism Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
M00535 Branched-chain amino acid metabolism Isoleucine biosynthesis, pyruvate => 2-oxobutanoate

Occurence in the database

K00052 is associated with 7 different proteins (see tab "Protein list" and "Profile")
The 7 proteins are classified into 1 different orthogroup(s)
# Orthogroup Locus Start Stop S. Gene Product Organism
0 group_870 PMI_RS10270 2251961 2253052 1 leuB 3-isopropylmalate dehydrogenase Proteus mirabilis HI4320
1 group_870 FBDBKF_04415 76270 77361 1 leuB 3-isopropylmalate dehydrogenase Morganella morganii S1
2 group_870 EHELCC_05705 135727 136818 1 leuB 3-isopropylmalate dehydrogenase Morganella morganii S2
3 group_870 NLDBIP_06025 176792 177883 1 leuB 3-isopropylmalate dehydrogenase Morganella morganii S4
4 group_870 LHKJJB_02905 154316 155407 1 leuB 3-isopropylmalate dehydrogenase Morganella morganii S3
5 group_870 HKOGLL_06380 76180 77271 1 leuB 3-isopropylmalate dehydrogenase Morganella morganii S5
6 group_870 F4V73_RS08860 1837377 1838492 1 leuB 3-isopropylmalate dehydrogenase Morganella psychrotolerans