Alzheimer disease


Help to interpret the results


The page contains two contents:
General: this table lists the KO entries and their description specific to this pathway, and provides their frequencies in Morganella morganii S5 and in the whole dataset.
Profile + homologs: the distribution of the Kegg entries of Alzheimer disease Kegg pathway is displayed here. Given a Kegg entry and a genome, a red box indicates that one or more loci have been annotated with, while a green box indicates that no locus/loci has(have) been annotated with it, but it/they is/are part of an Orthologous group in which other members have been annotated with that Kegg entry, so it is likely that this copy(ies) also performs this Kegg function.

Check the composition of the Alzheimer disease pathway


KO Description #in this genome All occurrences
K00134 glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] 1 7
K00182 wingless-type MMTV integration site family, member 2 0 0
K00234 succinate dehydrogenase (ubiquinone) flavoprotein subunit [EC:1.3.5.1] 0 0
K00235 succinate dehydrogenase (ubiquinone) iron-sulfur subunit [EC:1.3.5.1] 0 0
K00236 succinate dehydrogenase (ubiquinone) cytochrome b560 subunit 0 0
K00237 succinate dehydrogenase (ubiquinone) membrane anchor subunit 0 0
K00312 wingless-type MMTV integration site family, member 3 0 0
K00408 wingless-type MMTV integration site family, member 4 0 0
K00411 ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:7.1.1.8] 0 0
K00412 ubiquinol-cytochrome c reductase cytochrome b subunit 0 0
K00413 ubiquinol-cytochrome c reductase cytochrome c1 subunit 0 0
K00414 ubiquinol-cytochrome c reductase core subunit 1 0 0
K00415 ubiquinol-cytochrome c reductase core subunit 2 0 0
K00416 ubiquinol-cytochrome c reductase subunit 6 0 0
K00417 ubiquinol-cytochrome c reductase subunit 7 0 0
K00418 ubiquinol-cytochrome c reductase subunit 8 0 0
K00419 ubiquinol-cytochrome c reductase subunit 9 0 0
K00420 ubiquinol-cytochrome c reductase subunit 10 0 0
K00444 wingless-type MMTV integration site family, member 5 0 0
K00445 wingless-type MMTV integration site family, member 6 0 0
K00572 wingless-type MMTV integration site family, member 7 0 0
K00714 wingless-type MMTV integration site family, member 8 0 0
K00914 phosphatidylinositol 3-kinase [EC:2.7.1.137] 0 0
K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153] 0 0
K01059 lipoprotein lipase [EC:3.1.1.34] 0 0
K01064 wingless-type MMTV integration site family, member 9 0 0
K01357 wingless-type MMTV integration site family, member 10 0 0
K01367 calpain-1 [EC:3.4.22.52] 0 0
K01384 wingless-type MMTV integration site family, member 11 0 0
K01389 neprilysin [EC:3.4.24.11] 0 0
K01408 insulysin [EC:3.4.24.56] 0 0
K01558 wingless-type MMTV integration site family, member 16 0 0
K02084 apoptotic protease-activating factor 0 0
K02085 adenomatosis polyposis coli protein 0 0
K02090 cyclin-dependent kinase 5 [EC:2.7.11.22] 0 0
K02105 catenin beta 1 0 0
K02125 F-type H+-transporting ATPase subunit 8 0 0
K02126 F-type H+-transporting ATPase subunit a 0 0
K02127 F-type H+-transporting ATPase subunit b 0 0
K02128 F-type H+-transporting ATPase subunit c 0 0
K02131 F-type H+-transporting ATPase subunit 6 0 0
K02132 F-type H+-transporting ATPase subunit alpha 0 0
K02133 F-type H+-transporting ATPase subunit beta [EC:7.1.2.2] 0 0
K02134 F-type H+-transporting ATPase subunit delta 0 0
K02135 F-type H+-transporting ATPase subunit epsilon 0 0
K02136 F-type H+-transporting ATPase subunit gamma 0 0
K02137 F-type H+-transporting ATPase subunit O 0 0
K02138 F-type H+-transporting ATPase subunit d 0 0
K02157 axin 1 0 0
K02158 Bcl-2-antagonist of cell death 0 0
K02165 dickkopf 1/2/4 0 0
K02183 calmodulin 0 0
K02187 caspase 3 [EC:3.4.22.56] 0 0
K02235 frizzled 2 0 0
K02256 cytochrome c oxidase subunit 1 [EC:7.1.1.9] 0 0
K02261 cytochrome c oxidase subunit 2 0 0
K02262 cytochrome c oxidase subunit 3 0 0
K02263 cytochrome c oxidase subunit 4 0 0
K02264 cytochrome c oxidase subunit 5a 0 0
K02265 cytochrome c oxidase subunit 5b 0 0
K02266 cytochrome c oxidase subunit 6a 0 0
K02267 cytochrome c oxidase subunit 6b 0 0
K02268 cytochrome c oxidase subunit 6c 0 0
K02270 cytochrome c oxidase subunit 7a 0 0
K02271 cytochrome c oxidase subunit 7b 0 0
K02272 cytochrome c oxidase subunit 7c 0 0
K02273 cytochrome c oxidase subunit 8 0 0
K02329 frizzled 3 0 0
K02353 segment polarity protein dishevelled 0 0
K02354 frizzled 4 0 0
K02373 FAS-associated death domain protein 0 0
K02375 frizzled 5/8 0 0
K02376 frizzled 6 0 0
K02432 frizzled 1/7 0 0
K02580 nuclear factor NF-kappa-B p105 subunit 0 0
K02649 phosphoinositide-3-kinase regulatory subunit alpha/beta/delta 0 0
K02725 20S proteasome subunit alpha 6 [EC:3.4.25.1] 0 0
K02726 20S proteasome subunit alpha 2 [EC:3.4.25.1] 0 0
K02727 20S proteasome subunit alpha 7 [EC:3.4.25.1] 0 0
K02728 20S proteasome subunit alpha 3 [EC:3.4.25.1] 0 0
K02729 20S proteasome subunit alpha 5 [EC:3.4.25.1] 0 0
K02730 20S proteasome subunit alpha 1 [EC:3.4.25.1] 0 0
K02731 20S proteasome subunit alpha 4 [EC:3.4.25.1] 0 0
K02732 20S proteasome subunit beta 6 [EC:3.4.25.1] 0 0
K02734 20S proteasome subunit beta 4 [EC:3.4.25.1] 0 0
K02735 20S proteasome subunit beta 3 [EC:3.4.25.1] 0 0
K02736 20S proteasome subunit beta 7 [EC:3.4.25.1] 0 0
K02737 20S proteasome subunit beta 5 [EC:3.4.25.1] 0 0
K02738 20S proteasome subunit beta 1 [EC:3.4.25.1] 0 0
K02739 20S proteasome subunit beta 2 [EC:3.4.25.1] 0 0
K02833 GTPase HRas 0 0
K02842 frizzled 9/10 0 0
K03028 26S proteasome regulatory subunit N1 0 0
K03029 26S proteasome regulatory subunit N10 0 0
K03030 26S proteasome regulatory subunit N11 0 0
K03031 26S proteasome regulatory subunit N12 0 0
K03032 26S proteasome regulatory subunit N2 0 0
K03033 26S proteasome regulatory subunit N3 0 0
K03035 26S proteasome regulatory subunit N5 0 0
K03036 26S proteasome regulatory subunit N6 0 0
K03037 26S proteasome regulatory subunit N7 0 0
K03038 26S proteasome regulatory subunit N8 0 0
K03039 26S proteasome regulatory subunit N9 0 0
K03061 26S proteasome regulatory subunit T1 0 0
K03062 26S proteasome regulatory subunit T2 0 0
K03063 26S proteasome regulatory subunit T3 0 0
K03064 26S proteasome regulatory subunit T4 0 0
K03065 26S proteasome regulatory subunit T5 0 0
K03066 26S proteasome regulatory subunit T6 0 0
K03068 low density lipoprotein receptor-related protein 5/6 0 0
K03069 frequently rearranged in advanced T-cell lymphomas 1 0 0
K03083 glycogen synthase kinase 3 beta [EC:2.7.11.26] 0 0
K03096 frequently rearranged in advanced T-cell lymphomas 2 0 0
K03097 casein kinase II subunit alpha [EC:2.7.11.1] 0 0
K03115 casein kinase II subunit beta 0 0
K03156 tumor necrosis factor superfamily, member 2 0 0
K03158 tumor necrosis factor receptor superfamily member 1A 0 0
K03173 TNF receptor-associated factor 2 [EC:2.3.2.27] 0 0
K03209 wingless-type MMTV integration site family, member 1 0 0
K03237 translation initiation factor 2 subunit 1 0 0
K03853 calpain-2 [EC:3.4.22.53] 0 0
K03878 NADH-ubiquinone oxidoreductase chain 1 [EC:7.1.1.2] 0 0
K03879 NADH-ubiquinone oxidoreductase chain 2 [EC:7.1.1.2] 0 0
K03880 NADH-ubiquinone oxidoreductase chain 3 [EC:7.1.1.2] 0 0
K03881 NADH-ubiquinone oxidoreductase chain 4 [EC:7.1.1.2] 0 0
K03882 NADH-ubiquinone oxidoreductase chain 4L [EC:7.1.1.2] 0 0
K03883 NADH-ubiquinone oxidoreductase chain 5 [EC:7.1.1.2] 0 0
K03884 NADH-ubiquinone oxidoreductase chain 6 [EC:7.1.1.2] 0 0
K03934 NADH dehydrogenase (ubiquinone) Fe-S protein 1 [EC:7.1.1.2] 0 0
K03935 NADH dehydrogenase (ubiquinone) Fe-S protein 2 [EC:7.1.1.2] 0 0
K03936 NADH dehydrogenase (ubiquinone) Fe-S protein 3 [EC:7.1.1.2] 0 0
K03937 NADH dehydrogenase (ubiquinone) Fe-S protein 4 0 0
K03938 NADH dehydrogenase (ubiquinone) Fe-S protein 5 0 0
K03939 NADH dehydrogenase (ubiquinone) Fe-S protein 6 0 0
K03940 NADH dehydrogenase (ubiquinone) Fe-S protein 7 [EC:7.1.1.2] 0 0
K03941 NADH dehydrogenase (ubiquinone) Fe-S protein 8 [EC:7.1.1.2] 0 0
K03942 NADH dehydrogenase (ubiquinone) flavoprotein 1 [EC:7.1.1.2] 0 0
K03943 NADH dehydrogenase (ubiquinone) flavoprotein 2 [EC:7.1.1.2] 0 0
K03944 NADH dehydrogenase (ubiquinone) flavoprotein 3 0 0
K03945 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1 0 0
K03946 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 2 0 0
K03947 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 3 0 0
K03948 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 4 0 0
K03949 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 5 0 0
K03950 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 6 0 0
K03951 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 7 0 0
K03952 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 8 0 0
K03953 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 9 0 0
K03954 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 10 0 0
K03955 NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1, acyl-carrier protein 0 0
K03956 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 11 0 0
K03957 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 1 0 0
K03958 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 2 0 0
K03959 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 3 0 0
K03960 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 4 0 0
K03961 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 5 0 0
K03962 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 6 0 0
K03963 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 7 0 0
K03964 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 8 0 0
K03965 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 9 0 0
K03966 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 10 0 0
K03967 NADH dehydrogenase (ubiquinone) 1 subunit C1 0 0
K03968 NADH dehydrogenase (ubiquinone) 1 subunit C2 0 0
K04129 muscarinic acetylcholine receptor M1 0 0
K04131 muscarinic acetylcholine receptor M3 0 0
K04133 muscarinic acetylcholine receptor M5 0 0
K04348 serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16] 0 0
K04365 B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1] 0 0
K04366 RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1] 0 0
K04368 mitogen-activated protein kinase kinase 1 [EC:2.7.12.2] 0 0
K04369 mitogen-activated protein kinase kinase 2 [EC:2.7.12.2] 0 0
K04371 mitogen-activated protein kinase 1/3 [EC:2.7.11.24] 0 0
K04374 cyclic AMP-dependent transcription factor ATF-4 0 0
K04380 microtubule-associated protein tau 0 0
K04383 interleukin 1 alpha 0 0
K04385 axin 2 0 0
K04390 tumor necrosis factor receptor superfamily member 6 0 0
K04397 caspase 7 [EC:3.4.22.60] 0 0
K04398 caspase 8 [EC:3.4.22.61] 0 0
K04399 caspase 9 [EC:3.4.22.62] 0 0
K04426 mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25] 0 0
K04431 mitogen-activated protein kinase kinase 7 [EC:2.7.12.2] 0 0
K04440 mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24] 0 0
K04452 DNA damage-inducible transcript 3 0 0
K04456 RAC serine/threonine-protein kinase [EC:2.7.11.1] 0 0
K04467 inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10] 0 0
K04505 presenilin 1 [EC:3.4.23.-] 0 0
K04519 interleukin 1 beta 0 0
K04520 amyloid beta A4 protein 0 0
K04521 beta-site APP-cleaving enzyme 1 (memapsin 2) [EC:3.4.23.46] 0 0
K04522 presenilin 2 [EC:3.4.23.-] 0 0
K04524 apolipoprotein E 0 0
K04526 insulin 0 0
K04527 insulin receptor [EC:2.7.10.1] 0 0
K04528 alpha-synuclein 0 0
K04529 amyloid beta A4 precursor protein-binding family B member 1 0 0
K04532 NEDD8-activating enzyme E1 regulatory subunit 0 0
K04550 low-density lipoprotein receptor-related protein 1 (alpha-2-macroglobulin receptor) 0 0
K04604 metabotropic glutamate receptor 5 0 0
K04634 guanine nucleotide-binding protein G(q) subunit alpha 0 0
K04690 frizzled 0 0
K04726 BH3 interacting domain death agonist 0 0
K04735 transcription factor p65 0 0
K04741 caspase 12 [EC:3.4.22.-] 0 0
K04809 nicotinic acetylcholine receptor alpha-7 0 0
K04850 voltage-dependent calcium channel L type alpha-1C 0 0
K04851 voltage-dependent calcium channel L type alpha-1D 0 0
K04853 voltage-dependent calcium channel L type alpha-1F 0 0
K04857 voltage-dependent calcium channel L type alpha-1S 0 0
K04958 inositol 1,4,5-triphosphate receptor type 1 0 0
K04959 inositol 1,4,5-triphosphate receptor type 2 0 0
K04960 inositol 1,4,5-triphosphate receptor type 3 0 0
K04963 ryanodine receptor 3 0 0
K05208 glutamate receptor ionotropic, NMDA 1 0 0
K05209 glutamate receptor ionotropic, NMDA 2A 0 0
K05210 glutamate receptor ionotropic, NMDA 2B 0 0
K05211 glutamate receptor ionotropic, NMDA 2C 0 0
K05212 glutamate receptor ionotropic, NMDA 2D 0 0
K05405 interleukin 6 0 0
K05453 macrophage colony-stimulating factor 1 0 0
K05853 P-type Ca2+ transporter type 2A [EC:7.2.2.10] 0 0
K05858 phosphatidylinositol phospholipase C, beta [EC:3.1.4.11] 0 0
K05862 voltage-dependent anion channel protein 1 0 0
K05863 solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31 0 0
K05864 peptidyl-prolyl isomerase D [EC:5.2.1.8] 0 0
K06059 disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86] 0 0
K06170 presenilin enhancer 2 0 0
K06171 nicastrin 0 0
K06172 gamma-secretase subunit APH-1 0 0
K06268 serine/threonine-protein phosphatase 2B regulatory subunit 0 0
K06691 26S proteasome regulatory subunit N13 0 0
K06693 26S proteasome regulatory subunit N4 0 0
K06704 disintegrin and metalloproteinase domain-containing protein 10 [EC:3.4.24.81] 0 0
K07187 insulin receptor substrate 2 0 0
K07203 serine/threonine-protein kinase mTOR [EC:2.7.11.1] 0 0
K07209 inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10] 0 0
K07210 inhibitor of nuclear factor kappa-B kinase subunit gamma 0 0
K07374 tubulin alpha 0 0
K07375 tubulin beta 0 0
K07747 beta-site APP-cleaving enzyme 2 (memapsin 1) [EC:3.4.23.45] 0 0
K07827 GTPase KRas 0 0
K07828 GTPase NRas 0 0
K08008 NADPH oxidase 1 0 0
K08269 serine/threonine-protein kinase ULK2 [EC:2.7.11.1] 0 0
K08331 autophagy-related protein 13 0 0
K08333 phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1] 0 0
K08334 beclin 0 0
K08683 3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase [EC:1.1.1.35 1.1.1.178] 0 0
K08738 cytochrome c 0 0
K08845 A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1] 0 0
K08852 serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-] 0 0
K08860 eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1] 0 0
K08957 casein kinase 1, alpha [EC:2.7.11.1] 0 0
K08960 casein kinase 1, epsilon [EC:2.7.11.1] 0 0
K09027 X box-binding protein 1 0 0
K09054 cyclic AMP-dependent transcription factor ATF-6 alpha 0 0
K09565 peptidyl-prolyl isomerase F (cyclophilin D) [EC:5.2.1.8] 0 0
K10396 kinesin family member 5 0 0
K10407 kinesin light chain 0 0
K10881 26 proteasome complex subunit DSS1 0 0
K11351 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 11 0 0
K11352 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 12 0 0
K11353 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 13 0 0
K11716 cyclin-dependent kinase 5 activator 1 0 0
K11987 prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1] 0 0
K13240 nitric-oxide synthase, brain [EC:1.14.13.39] 0 0
K13241 nitric-oxide synthase, inducible [EC:1.14.13.39] 0 0
K14709 solute carrier family 39 (zinc transporter), member 1/2/3 0 0
K14710 solute carrier family 39 (zinc transporter), member 4 0 0
K14711 solute carrier family 39 (zinc transporter), member 5 0 0
K14712 solute carrier family 39 (zinc transporter), member 6 0 0
K14713 solute carrier family 39 (zinc transporter), member 7 0 0
K14714 solute carrier family 39 (zinc transporter), member 8 0 0
K14715 solute carrier family 39 (zinc transporter), member 9 0 0
K14716 solute carrier family 39 (zinc transporter), member 10 0 0
K14717 solute carrier family 39 (zinc transporter), member 11 0 0
K14718 solute carrier family 39 (zinc transporter), member 12 0 0
K14719 solute carrier family 39 (zinc transporter), member 13 0 0
K14720 solute carrier family 39 (zinc transporter), member 14 0 0
K15040 voltage-dependent anion channel protein 2 0 0
K15041 voltage-dependent anion channel protein 3 0 0
K16172 insulin receptor substrate 1 0 0
K16195 eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1] 0 0
K17445 insulin receptor substrate 3 0 0
K17446 insulin receptor substrate 4 0 0
K17589 RB1-inducible coiled-coil protein 1 0 0
K17889 beclin 1-associated autophagy-related key regulator 0 0
K17906 autophagy-related protein 2 0 0
K17908 autophagy-related protein 18 0 0
K17985 activating molecule in BECN1-regulated autophagy protein 1 0 0
K19722 receptor for advanced glycosylation end products 0 0
K19730 autophagy-related protein 101 0 0
K20720 reticulon-4 0 0
K20723 reticulon-3 0 0
K20858 calcium uniporter protein, mitochondrial 0 0
K21246 nuclear receptor-binding factor 2 0 0
K21357 serine/threonine-protein kinase ULK1 [EC:2.7.11.1] 0 0
K21398 natural resistance-associated macrophage protein 2 0 0
K21421 NADPH oxidase 2 [EC:1.-.-.-] 0 0
K21423 NADPH oxidase 4 [EC:1.6.3.-] 0 0