Help to interpret the results
The page contains two contents:
General: this table lists the KO entries and their description specific to this pathway, and provides their frequencies in and in the whole dataset.
Profile + homologs: the distribution of the Kegg entries of Cushing syndrome Kegg pathway is displayed here. Given a Kegg entry and a genome, a red box indicates that one or more loci have been annotated with, while a green box indicates that no locus/loci has(have) been annotated with it, but it/they is/are part of an Orthologous group in which other members have been annotated with that Kegg entry, so it is likely that this copy(ies) also performs this Kegg function.
Check the composition of the Cushing syndrome pathway
| KO | Description | All occurrences |
|---|---|---|
| K00070 | 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1] | 0 |
| K00182 | wingless-type MMTV integration site family, member 2 | 0 |
| K00312 | wingless-type MMTV integration site family, member 3 | 0 |
| K00408 | wingless-type MMTV integration site family, member 4 | 0 |
| K00444 | wingless-type MMTV integration site family, member 5 | 0 |
| K00445 | wingless-type MMTV integration site family, member 6 | 0 |
| K00497 | steroid 11beta-monooxygenase [EC:1.14.15.4] | 0 |
| K00498 | cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6] | 0 |
| K00512 | steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32] | 0 |
| K00513 | steroid 21-monooxygenase [EC:1.14.14.16] | 0 |
| K00572 | wingless-type MMTV integration site family, member 7 | 0 |
| K00714 | wingless-type MMTV integration site family, member 8 | 0 |
| K01064 | wingless-type MMTV integration site family, member 9 | 0 |
| K01357 | wingless-type MMTV integration site family, member 10 | 0 |
| K01384 | wingless-type MMTV integration site family, member 11 | 0 |
| K01558 | wingless-type MMTV integration site family, member 16 | 0 |
| K01679 | fumarate hydratase, class II [EC:4.2.1.2] | 7 |
| K02085 | adenomatosis polyposis coli protein | 0 |
| K02089 | cyclin-dependent kinase 4 [EC:2.7.11.22] | 0 |
| K02091 | cyclin-dependent kinase 6 [EC:2.7.11.22] | 0 |
| K02105 | catenin beta 1 | 0 |
| K02157 | axin 1 | 0 |
| K02206 | cyclin-dependent kinase 2 [EC:2.7.11.22] | 0 |
| K02235 | frizzled 2 | 0 |
| K02329 | frizzled 3 | 0 |
| K02353 | segment polarity protein dishevelled | 0 |
| K02354 | frizzled 4 | 0 |
| K02375 | frizzled 5/8 | 0 |
| K02376 | frizzled 6 | 0 |
| K02432 | frizzled 1/7 | 0 |
| K02620 | transcription factor 7 | 0 |
| K02842 | frizzled 9/10 | 0 |
| K03083 | glycogen synthase kinase 3 beta [EC:2.7.11.26] | 0 |
| K03209 | wingless-type MMTV integration site family, member 1 | 0 |
| K04166 | angiotensin II receptor type 1 | 0 |
| K04200 | melanocortin 2 receptor | 0 |
| K04345 | protein kinase A [EC:2.7.11.11] | 0 |
| K04353 | Ras-related protein Rap-1A | 0 |
| K04361 | epidermal growth factor receptor [EC:2.7.10.1] | 0 |
| K04365 | B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1] | 0 |
| K04368 | mitogen-activated protein kinase kinase 1 [EC:2.7.12.2] | 0 |
| K04369 | mitogen-activated protein kinase kinase 2 [EC:2.7.12.2] | 0 |
| K04371 | mitogen-activated protein kinase 1/3 [EC:2.7.11.24] | 0 |
| K04374 | cyclic AMP-dependent transcription factor ATF-4 | 0 |
| K04385 | axin 2 | 0 |
| K04450 | cyclic AMP-dependent transcription factor ATF-2 | 0 |
| K04465 | nuclear receptor subfamily 4 group A member 1 | 0 |
| K04490 | transcription factor 7-like 1 | 0 |
| K04491 | transcription factor 7-like 2 | 0 |
| K04492 | lymphoid enhancer-binding factor 1 | 0 |
| K04503 | G1/S-specific cyclin-D1 | 0 |
| K04515 | calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17] | 0 |
| K04578 | corticotropin releasing hormone receptor 1 | 0 |
| K04579 | corticotropin releasing hormone receptor 2 | 0 |
| K04630 | guanine nucleotide-binding protein G(i) subunit alpha | 0 |
| K04632 | guanine nucleotide-binding protein G(s) subunit alpha | 0 |
| K04634 | guanine nucleotide-binding protein G(q) subunit alpha | 0 |
| K04635 | guanine nucleotide-binding protein subunit alpha-11 | 0 |
| K04684 | transcription factor Sp1 | 0 |
| K04685 | cyclin-dependent kinase inhibitor 2B | 0 |
| K04850 | voltage-dependent calcium channel L type alpha-1C | 0 |
| K04851 | voltage-dependent calcium channel L type alpha-1D | 0 |
| K04853 | voltage-dependent calcium channel L type alpha-1F | 0 |
| K04854 | voltage-dependent calcium channel T type alpha-1G | 0 |
| K04855 | voltage-dependent calcium channel T type alpha-1H | 0 |
| K04856 | voltage-dependent calcium channel T type alpha-1I | 0 |
| K04857 | voltage-dependent calcium channel L type alpha-1S | 0 |
| K04877 | potassium voltage-gated channel Shaker-related subfamily A member 4 | 0 |
| K04913 | potassium channel subfamily K member 2 | 0 |
| K04914 | potassium channel subfamily K member 3 | 0 |
| K04958 | inositol 1,4,5-triphosphate receptor type 1 | 0 |
| K04959 | inositol 1,4,5-triphosphate receptor type 2 | 0 |
| K04960 | inositol 1,4,5-triphosphate receptor type 3 | 0 |
| K05228 | proopiomelanocortin | 0 |
| K05256 | corticotropin-releasing hormone | 0 |
| K05858 | phosphatidylinositol phospholipase C, beta [EC:3.1.4.11] | 0 |
| K05870 | cyclic AMP-responsive element-binding protein 1 | 0 |
| K06618 | retinoblastoma-associated protein | 0 |
| K06620 | transcription factor E2F3 | 0 |
| K06621 | cyclin-dependent kinase inhibitor 2A | 0 |
| K06622 | cyclin-dependent kinase inhibitor 2C | 0 |
| K06624 | cyclin-dependent kinase inhibitor 1B | 0 |
| K06625 | cyclin-dependent kinase inhibitor 1A | 0 |
| K06626 | G1/S-specific cyclin-E1 | 0 |
| K07836 | Ras-related protein Rap-1B | 0 |
| K07843 | RAS, dexamethasone-induced Ras-related protein 1 | 0 |
| K08041 | adenylate cyclase 1 [EC:4.6.1.1] | 0 |
| K08042 | adenylate cyclase 2 [EC:4.6.1.1] | 0 |
| K08043 | adenylate cyclase 3 [EC:4.6.1.1] | 0 |
| K08044 | adenylate cyclase 4 [EC:4.6.1.1] | 0 |
| K08045 | adenylate cyclase 5 [EC:4.6.1.1] | 0 |
| K08046 | adenylate cyclase 6 [EC:4.6.1.1] | 0 |
| K08047 | adenylate cyclase 7 [EC:4.6.1.1] | 0 |
| K08048 | adenylate cyclase 8 [EC:4.6.1.1] | 0 |
| K08049 | adenylate cyclase 9 [EC:4.6.1.1] | 0 |
| K08560 | steroidogenic factor 1 | 0 |
| K09047 | cyclic AMP-responsive element-binding protein 5 | 0 |
| K09048 | cyclic AMP-responsive element-binding protein 3 | 0 |
| K09049 | cyclic AMP-dependent transcription factor ATF-6 beta | 0 |
| K09093 | aryl hydrocarbon receptor | 0 |
| K09097 | aryl hydrocarbon receptor nuclear translocator | 0 |
| K09186 | [histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354] | 0 |
| K09187 | [histone H3]-lysine4 N-trimethyltransferase MLL2 [EC:2.1.1.354] | 0 |
| K09355 | pre-B-cell leukemia transcription factor 1 | 0 |
| K09389 | transcription factor E2F2 | 0 |
| K09821 | angiotensinogen | 0 |
| K11839 | ubiquitin carboxyl-terminal hydrolase 8 [EC:3.4.19.12] | 0 |
| K12473 | low-density lipoprotein receptor | 0 |
| K13298 | dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 [EC:3.1.4.17 3.1.4.35] | 0 |
| K13885 | scavenger receptor class B, member 1 | 0 |
| K14349 | neutral cholesterol ester hydrolase 1 [EC:3.1.1.-] | 0 |
| K14961 | COMPASS component SWD1 | 0 |
| K14963 | COMPASS component SWD3 | 0 |
| K14964 | Set1/Ash2 histone methyltransferase complex subunit ASH2 | 0 |
| K14970 | menin | 0 |
| K16056 | calcium release-activated calcium channel protein 1 | 0 |
| K16931 | steroidogenic acute regulatory protein, mitochondrial | 0 |
| K17454 | transcription factor E2F1 | 0 |
| K17767 | AH receptor-interacting protein | 0 |
| K18437 | high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:3.1.4.53] | 0 |
| K22398 | melanocortin-2 receptor accessory protein | 0 |
| K22499 | armadillo repeat-containing protein 5 | 0 |