Orthogroup:group_296


Homologs in group_296

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8 homologs were identified in 7 genomes with OrthoFinder.
The following table displays the locus tag of each homolog, the organism to which it belongs, the gene name and product.

Locus tag Source Gene Product
FBDBKF_07445 FBDBKF_07445 Morganella morganii S1 cobA Uroporphyrinogen-III methylase (siroheme synthase)
EHELCC_17115 EHELCC_17115 Morganella morganii S2 cobA Uroporphyrinogen-III methylase (siroheme synthase)
NLDBIP_18495 NLDBIP_18495 Morganella morganii S4 cobA Uroporphyrinogen-III methylase (siroheme synthase)
LHKJJB_09130 LHKJJB_09130 Morganella morganii S3 cobA Uroporphyrinogen-III methylase (siroheme synthase)
HKOGLL_08680 HKOGLL_08680 Morganella morganii S5 cobA Uroporphyrinogen-III methylase (siroheme synthase)
F4V73_RS13675 F4V73_RS13675 Morganella psychrotolerans cobA uroporphyrinogen-III C-methyltransferase
PMI_RS07150 PMI_RS07150 Proteus mirabilis HI4320 cysG siroheme synthase CysG
PMI_RS11070 PMI_RS11070 Proteus mirabilis HI4320 cysG siroheme synthase CysG

Distribution of group_296 homologs

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Number of homologs in each genome (first column and blue bar chart)

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Phylogeny of group_296 (midpoint rooted)


Phylogeny of the RefSeq best hits of group_296

Orthogroup content: 8 members

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This page summarizes the annotation of all members of the orthologous group group_296.
Gene name(s), gene product(s), a summary of protein lenght, and annotations (when available) are provided. Additionally, the number of times (occurence) an annotation is observed in the orthogroup is reported for each annotation.

Orthologs were identified with OrthoFinder. The annotation of orthologous proteins can differ depending the approach used to annotate the source genomes. Automated annotations are also subject to errors. Spurious clustering of non-orthologous proteins can also happen. This page allows to check for eventual inconsistencies.

Gene

# Gene name Occurence
1 cobA 6
2 cysG 2

Product

# Product Occurence
1 Uroporphyrinogen-III methylase (siroheme synthase) 5
2 uroporphyrinogen-III C-methyltransferase 1
3 siroheme synthase CysG 2

COG entry Annotation(s)

ID Occurences Function(s) cat. Function(s) descr. Description
COG0007 8 H Coenzyme transport and metabolism (H) Uroporphyrinogen-III methylase (siroheme synthase)

Kegg Ortholog Annotation(s)

KO Occurences Description Pathways Modules
K02302 2 uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:2.1.1.107 1.3.1.76 4.99.1.4] Porphyrin metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Biosynthesis of cofactors		 Siroheme biosynthesis, glutamyl-tRNA => siroheme
Cobalamin biosynthesis, anaerobic, uroporphyrinogen III => sirohydrochlorin => cobyrinate a,c-diamide
K02303 6 uroporphyrin-III C-methyltransferase [EC:2.1.1.107] Porphyrin metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Biosynthesis of cofactors		 Siroheme biosynthesis, glutamyl-tRNA => siroheme
Cobalamin biosynthesis, anaerobic, uroporphyrinogen III => sirohydrochlorin => cobyrinate a,c-diamide
Cobalamin biosynthesis, aerobic, uroporphyrinogen III => precorrin 2 => cobyrinate a,c-diamide

Pfam domain Annotation(s)

Domain ID Occurences Description
PF00590 8 Tetrapyrrole (Corrin/Porphyrin) Methylases
PF10414 2 Sirohaem synthase dimerisation region
PF13241 2 Putative NAD(P)-binding
PF14824 2 Sirohaem biosynthesis protein central

Annotations of the 186 SwissProt hits

Annotation Number of occurrences
Cobalamin biosynthesis protein CbiHC 1
Cobalt-factor III methyltransferase 1
Cobalt-precorrin-4 C(11)-methyltransferase 4
Diphthine synthase 5
Porphyrin biosynthesis protein HemD 1
Precorrin-2 C(20)-methyltransferase 2
Precorrin-2 dehydrogenase 3
Precorrin-3B C(17)-methyltransferase 1
Precorrin-4 C(11)-methyltransferase 6
Probable cobalt-factor III C(17)-methyltransferase 1
Probable cobalt-precorrin-7 C(5)-methyltransferase 1
Probable multifunctional siroheme biosynthesis protein HemA 1
Probable uroporphyrinogen-III C-methyltransferase 1
Putative precorrin-2 dehydrogenase 1
S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferase 1
S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferase, chloroplastic 1
Siroheme biosynthesis protein met8 1
Siroheme synthase 116
Siroheme synthase 1 12
Siroheme synthase 2 12
Siroheme synthase 3 1
Uroporphyrinogen-III C-methyltransferase 13

Protein length

Min length 261
Max length 473
Mean length (sd) 312.4 (95.2)
Median length 261.0

Protein length distribution