VFG049124


Help to interpret the results

Three outputs have been generated:
General: this tab contains the description, occurence in the database and other information related to the selected Virulence factor VFG049124
Protein list: lists the 1 occurences of the Virulence factor within the database. The table reports information on each occurence.
Profile: phylogenetic tree annotated with
- the presence of the Virulence factor of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Virulence factor has been clustered.
Orthogroups are shown in red if they are annotated with that particular Virulence factor in a given genome , in green otherwise, i.e. if there is a discrepency between orthogroup clustering and Virulence factor prediction.
Green homologs (same orthogroup) are not positive hit(s) for the considered Virulence factor.
Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Virulence factor prediction.

Description

Protein ureidoglycolate dehydrogenase
VF ID VF0572
Category Nutritional/Metabolic factor
Protein ID WP_012737540
Characteristics An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses.
Function Providing a nitrogen source to increase virulence in K. pneumoniae at certain sites of infection
Mechanism Allantoin is a metabolic intermediate of purine degradation by various organisms including microbes and has been identified as a source of nitrogen in various bacterial species and as both a nitrogen source and a carbon source in K. pneumoniae.
Vf_category_id VFC0272

Occurence in the database

VFG049124 is associated with 1 different proteins
The 1 proteins are classified into 1 different orthogroup(s)
Orthogroup Locus Start Stop S. Gene Product Organism
0 group_4439 PMI_RS03455 766835 767884 1 allD ureidoglycolate dehydrogenase Proteus mirabilis HI4320