VFG049124


Help to interpret the results

Three outputs have been generated:
General: this result contains the description and frequency of the selected Virulence factors VFG049124, of which KO pathways and KO modules it is part. Additionally, its occurence in the database is reported.
Proteins list: list of occurences of the Virulence factors within the database. 1 occurences are identified. The table reports the orthogroup, the organism in which each occurrence has been found, and the locus tag enriched by start and stop position, strand, gene name and product.
Clicking on the Ortohgroup name or locus you will be redirected to further info.
Profiles: Phylogenetic tree annotated with
- the presence of the Virulence factor(s) of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Virulence factors has been clustered.
In red the Virulence factors with positive hit(s) in the corresponding genome.
In green the discrepencies between orthogroup clustering and Virulence factors prediction. Green homologs (same orthogroup) are not positive hit(s) for the considered Virulence factors.

Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Virulence factors prediction.

Description

Protein ureidoglycolate dehydrogenase
VF ID VF0572
Category Nutritional/Metabolic factor
Protein ID WP_012737540
Characteristics An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses.
Function Providing a nitrogen source to increase virulence in K. pneumoniae at certain sites of infection
Mechanism Allantoin is a metabolic intermediate of purine degradation by various organisms including microbes and has been identified as a source of nitrogen in various bacterial species and as both a nitrogen source and a carbon source in K. pneumoniae.
Vf_category_id VFC0272

Occurence in the database

VFG049124 is associated with 1 different proteins (see tab "Protein list" and "Profile")
The 1 proteins are classified into 1 different orthogroup(s)
# Orthogroup Locus Start Stop S. Gene Product Organism
0 group_4366 PMI_RS03455 766835 767884 1 allD ureidoglycolate dehydrogenase Proteus mirabilis HI4320