VFG048941


Help to interpret the results

Three outputs have been generated:
General: this tab contains the description, occurence in the database and other information related to the selected Virulence factor VFG048941
Protein list: lists the 5 occurences of the Virulence factor within the database. The table reports information on each occurence.
Profile: phylogenetic tree annotated with
- the presence of the Virulence factor of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Virulence factor has been clustered.
Orthogroups are shown in red if they are annotated with that particular Virulence factor in a given genome , in green otherwise, i.e. if there is a discrepency between orthogroup clustering and Virulence factor prediction.
Green homologs (same orthogroup) are not positive hit(s) for the considered Virulence factor.
Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Virulence factor prediction.

Description

Protein NADP-dependent phosphogluconate dehydrogenase
VF ID VF0560
Category Immune modulation
Protein ID WP_020953355
Characteristics The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease.
Function Assisting in evading the host immune system by protecting bacteria from opsonophagocytosis and serum killing
Vf_category_id VFC0258

Occurence in the database

VFG048941 is associated with 5 different proteins
The 5 proteins are classified into 1 different orthogroup(s)
Orthogroup Locus Start Stop S. Gene Product Organism
0 group_1249 FBDBKF_06870 37974 39386 -1 gndA NADP-dependent phosphogluconate dehydrogenase Morganella morganii S1
1 group_1249 EHELCC_04100 146800 148212 1 gndA NADP-dependent phosphogluconate dehydrogenase Morganella morganii S2
2 group_1249 NLDBIP_04100 146596 148008 1 gndA NADP-dependent phosphogluconate dehydrogenase Morganella morganii S4
3 group_1249 LHKJJB_09930 146710 148122 1 gndA NADP-dependent phosphogluconate dehydrogenase Morganella morganii S3
4 group_1249 HKOGLL_09045 42930 44342 -1 gndA NADP-dependent phosphogluconate dehydrogenase Morganella morganii S5