VFG048941


Help to interpret the results

Three outputs have been generated:
General: this result contains the description and frequency of the selected Virulence factors VFG048941, of which KO pathways and KO modules it is part. Additionally, its occurence in the database is reported.
Proteins list: list of occurences of the Virulence factors within the database. 5 occurences are identified. The table reports the orthogroup, the organism in which each occurrence has been found, and the locus tag enriched by start and stop position, strand, gene name and product.
Clicking on the Ortohgroup name or locus you will be redirected to further info.
Profiles: Phylogenetic tree annotated with
- the presence of the Virulence factor(s) of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Virulence factors has been clustered.
In red the Virulence factors with positive hit(s) in the corresponding genome.
In green the discrepencies between orthogroup clustering and Virulence factors prediction. Green homologs (same orthogroup) are not positive hit(s) for the considered Virulence factors.

Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Virulence factors prediction.

Description

Protein NADP-dependent phosphogluconate dehydrogenase
VF ID VF0560
Category Immune modulation
Protein ID WP_020953355
Characteristics The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease.
Function Assisting in evading the host immune system by protecting bacteria from opsonophagocytosis and serum killing
Vf_category_id VFC0258

Occurence in the database

VFG048941 is associated with 5 different proteins (see tab "Protein list" and "Profile")
The 5 proteins are classified into 1 different orthogroup(s)
# Orthogroup Locus Start Stop S. Gene Product Organism
0 group_1190 FBDBKF_06870 37974 39386 -1 gndA NADP-dependent phosphogluconate dehydrogenase Morganella morganii S1
1 group_1190 EHELCC_04100 146800 148212 1 gndA NADP-dependent phosphogluconate dehydrogenase Morganella morganii S2
2 group_1190 NLDBIP_04100 146596 148008 1 gndA NADP-dependent phosphogluconate dehydrogenase Morganella morganii S4
3 group_1190 LHKJJB_09930 146710 148122 1 gndA NADP-dependent phosphogluconate dehydrogenase Morganella morganii S3
4 group_1190 HKOGLL_09045 42930 44342 -1 gndA NADP-dependent phosphogluconate dehydrogenase Morganella morganii S5