VFG038915


Help to interpret the results

Three outputs have been generated:
General: this result contains the description and frequency of the selected Virulence factors VFG038915, of which KO pathways and KO modules it is part. Additionally, its occurence in the database is reported.
Proteins list: list of occurences of the Virulence factors within the database. 1 occurences are identified. The table reports the orthogroup, the organism in which each occurrence has been found, and the locus tag enriched by start and stop position, strand, gene name and product.
Clicking on the Ortohgroup name or locus you will be redirected to further info.
Profiles: Phylogenetic tree annotated with
- the presence of the Virulence factor(s) of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Virulence factors has been clustered.
In red the Virulence factors with positive hit(s) in the corresponding genome.
In green the discrepencies between orthogroup clustering and Virulence factors prediction. Green homologs (same orthogroup) are not positive hit(s) for the considered Virulence factors.

Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Virulence factors prediction.

Description

Protein conserved hypothetical protein in rtx gene loci
VF ID VF0482
Category Exotoxin
Protein ID WP_011705264
Characteristics A member of a protein family that is produced by a wide range of Gram-negative bacteria, such as Vibrio cholerae, V. vulnificus, V. anguillarum, Actinobacillus actinomycetemcomitans, Actinobacillus pleuropneumoniae,etc.; the rtx operon consists of six genes (rtxACHBDE) in which rtxA encodes an exotoxin, rtxC codes for an RtxA activator, rtxH encodes a conserved hypothetical protein and rtxBDE genes code for an ABC transporter; important characteristics of this toxin include:; I) it requires post-translational modification, i.e., acylation to become biologically active; II) has a COOH-terminal calcium-binding domain with tandem glycine/aspartic acid-rich repeats; III) it has a high molecular mass of usually 100 to >400 kDa; IV) it is delivered to the extracellular milieu through the T1SS
Function Inducing host cell rounding and apoptosis
Mechanism Actin cross-linking domain of RtxA catalyzed the covalent cross-linking of the host cellular actin, thus disrupted the actin cytoskeleton of host cells
Vf_category_id VFC0235

Occurence in the database

VFG038915 is associated with 1 different proteins (see tab "Protein list" and "Profile")
The 1 proteins are classified into 1 different orthogroup(s)
# Orthogroup Locus Start Stop S. Gene Product Organism
0 group_4521 PMI_RS19455 2184503 2184649 1 hypothetical protein Proteus mirabilis HI4320