VFG038915
Help to interpret the results
Three outputs have been generated:
General: this tab contains the description, occurence in the database and other information related to the selected Virulence factor VFG038915
Protein list: lists the 1 occurences of the Virulence factor within the database. The table reports information on each occurence.
Profile: phylogenetic tree annotated with
- the presence of the Virulence factor of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Virulence factor has been clustered.
Orthogroups are shown in red if they are annotated with that particular Virulence factor in a given genome , in green otherwise, i.e. if there is a discrepency between orthogroup clustering and Virulence factor prediction.
Green homologs (same orthogroup) are not positive hit(s) for the considered Virulence factor.
Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Virulence factor prediction.
Description
| Protein |
conserved hypothetical protein in rtx gene loci |
| VF ID |
VF0482 |
| Category |
Exotoxin |
| Protein ID |
WP_011705264 |
| Characteristics |
A member of a protein family that is produced by a wide range of Gram-negative bacteria, such as Vibrio cholerae, V. vulnificus, V. anguillarum, Actinobacillus actinomycetemcomitans, Actinobacillus pleuropneumoniae,etc.; the rtx operon consists of six genes (rtxACHBDE) in which rtxA encodes an exotoxin, rtxC codes for an RtxA activator, rtxH encodes a conserved hypothetical protein and rtxBDE genes code for an ABC transporter; important characteristics of this toxin include:; I) it requires post-translational modification, i.e., acylation to become biologically active; II) has a COOH-terminal calcium-binding domain with tandem glycine/aspartic acid-rich repeats; III) it has a high molecular mass of usually 100 to >400 kDa; IV) it is delivered to the extracellular milieu through the T1SS |
| Function |
Inducing host cell rounding and apoptosis |
| Mechanism |
Actin cross-linking domain of RtxA catalyzed the covalent cross-linking of the host cellular actin, thus disrupted the actin cytoskeleton of host cells |
| Vf_category_id |
VFC0235 |
Occurence in the database
| VFG038915 is associated with 1 different
proteins
|
|
The 1 proteins are classified into 1 different orthogroup(s)
|
|
Orthogroup |
Locus |
Start |
Stop |
S. |
Gene |
Product |
Organism |
| 0 |
group_4414 |
PMI_RS19455 |
2184503 |
2184649 |
1 |
|
hypothetical protein |
Proteus mirabilis HI4320 |
