VFG038369
Help to interpret the results
Three outputs have been generated:
General: this result contains the description and frequency of the selected Virulence factors VFG038369, of which KO pathways and KO modules it is part. Additionally, its occurence in the database is reported.
Proteins list: list of occurences of the Virulence factors
within the database. 6 occurences are identified.
The table reports the orthogroup, the organism in which each occurrence has been found, and the locus tag enriched by start and stop position, strand, gene name and product.
Clicking on the Ortohgroup name or locus you will be redirected to further info.
Profiles: Phylogenetic tree annotated with
- the presence of the Virulence factor(s) of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Virulence factors has been clustered.
In red the Virulence factors with positive hit(s) in the corresponding genome.
In green the discrepencies between orthogroup clustering and Virulence factors prediction.
Green homologs (same orthogroup) are not positive hit(s) for the considered Virulence factors.
Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Virulence factors prediction.
Description
Protein |
hemolysin co-regulated protein |
VF ID |
VF0480 |
Category |
Effector delivery system |
Protein ID |
WP_011705706 |
Function |
A phagetail-spike-like injectisome to translocate virulence determinants directly into the host cell cytoplasm; Four effectors of the T6SS have so far been characterized, Hcp1, Vgr1, Vgr2 and Vgr3; Hcp is a powerful effector substrate and once translocated into the targeted host cell cytoplasm, apoptosis ensues following caspase 3 activation; Hcp paralyzes macrophages to prevent phagocytosis;Vgr1 is an ADP-ribosylating toxin capable of interrupting the host cell cytoskeleton and inducing apoptosis |
Vf_category_id |
VFC0086 |
Occurence in the database
VFG038369 is associated with 6 different proteins (see tab "Protein list" and "Profile") |
The 6 proteins are classified into 1 different orthogroup(s)
|
# |
Orthogroup |
Locus |
Start |
Stop |
S. |
Gene |
Product |
Organism |
0 |
group_168 |
FBDBKF_16725 |
26941 |
27459 |
-1 |
hcp |
Type VI protein secretion system component Hcp (secreted cytotoxin) |
Morganella morganii S1 |
1 |
group_168 |
EHELCC_10735 |
186312 |
186830 |
1 |
hcp |
Type VI protein secretion system component Hcp (secreted cytotoxin) |
Morganella morganii S2 |
2 |
group_168 |
NLDBIP_11080 |
164583 |
165101 |
1 |
hcp |
Type VI protein secretion system component Hcp (secreted cytotoxin) |
Morganella morganii S4 |
3 |
group_168 |
LHKJJB_10275 |
26427 |
26945 |
-1 |
hcp |
Type VI protein secretion system component Hcp (secreted cytotoxin) |
Morganella morganii S3 |
4 |
group_168 |
HKOGLL_16440 |
26436 |
26954 |
-1 |
hcp |
Type VI protein secretion system component Hcp (secreted cytotoxin) |
Morganella morganii S5 |
5 |
group_168 |
F4V73_RS05140 |
1097166 |
1097684 |
-1 |
|
Hcp family type VI secretion system effector |
Morganella psychrotolerans |