VFG006476
Help to interpret the results
Three outputs have been generated:
General: this result contains the description and frequency of the selected Virulence factors VFG006476, of which KO pathways and KO modules it is part. Additionally, its occurence in the database is reported.
Proteins list: list of occurences of the Virulence factors
within the database. 1 occurences are identified.
The table reports the orthogroup, the organism in which each occurrence has been found, and the locus tag enriched by start and stop position, strand, gene name and product.
Clicking on the Ortohgroup name or locus you will be redirected to further info.
Profiles: Phylogenetic tree annotated with
- the presence of the Virulence factor(s) of interest within all the genomes of the database (first column)
- the size of the orthogroup(s) in which the reported Virulence factors has been clustered.
In red the Virulence factors with positive hit(s) in the corresponding genome.
In green the discrepencies between orthogroup clustering and Virulence factors prediction.
Green homologs (same orthogroup) are not positive hit(s) for the considered Virulence factors.
Variations within orthogroups may be due to the clustering of multi domain proteins or because of erroneous homolog clustering or Virulence factors prediction.
Description
Protein |
urease beta subunit UreB, urea amidohydrolase |
VF ID |
VF0050 |
Category |
Stress survival |
Protein ID |
WP_011115250 |
Structure |
~550kDa nickel metalloenzyme comprised of two distinct subunits-UreA and UreB, the UreEFGH proteins are required for activation of urease by incorporating nickel ions into the urease apoenzyme, UreI functions as an acid-dependent urea channel; PDB code: 1E9Z |
Function |
An important colonization factor, contributes to acid resistance, epithelial cell damage, chemotactic behavior, and nitrogen metabolism |
Mechanism |
A Ni2+-containing enzyme, catalyzes the hydrolysis of urea to ammonium and carbon dioxide. Urea channels (UreI) present in the inner membrane are opened at pH<6.5, allowing delivery of urea to urease. The ammonia produced diffuses into, and thus buffers the periplasm. |
Vf_category_id |
VFC0282 |
Occurence in the database
VFG006476 is associated with 1 different proteins (see tab "Protein list" and "Profile") |
The 1 proteins are classified into 1 different orthogroup(s)
|
# |
Orthogroup |
Locus |
Start |
Stop |
S. |
Gene |
Product |
Organism |
0 |
group_1160 |
PMI_RS18335 |
4025375 |
4027078 |
1 |
ureC |
urease subunit alpha |
Proteus mirabilis HI4320 |