Help to interpret the results
The page contains two contents:
General: this table lists the KO entries and their description specific to this pathway, and provides their frequencies in and in the whole dataset.
Profile + homologs: the distribution of the Kegg entries of Insulin signaling pathway Kegg pathway is displayed here. Given a Kegg entry and a genome, a red box indicates that one or more loci have been annotated with, while a green box indicates that no locus/loci has(have) been annotated with it, but it/they is/are part of an Orthologous group in which other members have been annotated with that Kegg entry, so it is likely that this copy(ies) also performs this Kegg function.
Check the composition of the Insulin signaling pathway pathway
| KO | Description | All occurrences |
|---|---|---|
| K00665 | fatty acid synthase, animal type [EC:2.3.1.85] | 0 |
| K00688 | glycogen phosphorylase [EC:2.4.1.1] | 0 |
| K00693 | glycogen synthase [EC:2.4.1.11] | 0 |
| K00844 | hexokinase [EC:2.7.1.1] | 0 |
| K00871 | phosphorylase kinase gamma subunit [EC:2.7.11.19] | 0 |
| K00922 | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153] | 0 |
| K01084 | glucose-6-phosphatase [EC:3.1.3.9] | 0 |
| K01106 | inositol polyphosphate 5-phosphatase INPP5A [EC:3.1.3.56] | 0 |
| K01596 | phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32] | 0 |
| K01946 | acetyl-CoA carboxylase / biotin carboxylase 2 [EC:6.4.1.2 6.3.4.14 2.1.3.15] | 0 |
| K02158 | Bcl-2-antagonist of cell death | 0 |
| K02183 | calmodulin | 0 |
| K02649 | phosphoinositide-3-kinase regulatory subunit alpha/beta/delta | 0 |
| K02833 | GTPase HRas | 0 |
| K02991 | small subunit ribosomal protein S6e | 0 |
| K03083 | glycogen synthase kinase 3 beta [EC:2.7.11.26] | 0 |
| K03099 | son of sevenless | 0 |
| K03259 | translation initiation factor 4E | 0 |
| K03841 | fructose-1,6-bisphosphatase I [EC:3.1.3.11] | 7 |
| K04345 | protein kinase A [EC:2.7.11.11] | 0 |
| K04364 | growth factor receptor-bound protein 2 | 0 |
| K04365 | B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1] | 0 |
| K04366 | RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1] | 0 |
| K04368 | mitogen-activated protein kinase kinase 1 [EC:2.7.12.2] | 0 |
| K04369 | mitogen-activated protein kinase kinase 2 [EC:2.7.12.2] | 0 |
| K04371 | mitogen-activated protein kinase 1/3 [EC:2.7.11.24] | 0 |
| K04372 | MAP kinase interacting serine/threonine kinase [EC:2.7.11.1] | 0 |
| K04375 | ETS domain-containing protein Elk-1 | 0 |
| K04438 | C-crk adapter molecule crk | 0 |
| K04440 | mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24] | 0 |
| K04456 | RAC serine/threonine-protein kinase [EC:2.7.11.1] | 0 |
| K04526 | insulin | 0 |
| K04527 | insulin receptor [EC:2.7.10.1] | 0 |
| K04688 | ribosomal protein S6 kinase beta [EC:2.7.11.1] | 0 |
| K04694 | suppressor of cytokine signaling 1 | 0 |
| K04695 | suppressor of cytokine signaling 2 | 0 |
| K04696 | suppressor of cytokine signaling 3 | 0 |
| K04697 | suppressor of cytokine signaling 4 | 0 |
| K04707 | E3 ubiquitin-protein ligase CBL [EC:2.3.2.27] | 0 |
| K04739 | cAMP-dependent protein kinase regulator | 0 |
| K05695 | receptor-type tyrosine-protein phosphatase F [EC:3.1.3.48] | 0 |
| K05696 | tyrosine-protein phosphatase non-receptor type 1 [EC:3.1.3.48] | 0 |
| K06069 | atypical protein kinase C iota type [EC:2.7.11.13] | 0 |
| K06086 | sorbin and SH3 domain containing protein 1 | 0 |
| K06269 | serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] | 0 |
| K06276 | 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1] | 0 |
| K06277 | Rap guanine nucleotide exchange factor 1 | 0 |
| K06279 | SHC-transforming protein 1 | 0 |
| K07187 | insulin receptor substrate 2 | 0 |
| K07188 | hormone-sensitive lipase [EC:3.1.1.79] | 0 |
| K07189 | protein phosphatase 1 regulatory subunit 3A/B/C/D/E | 0 |
| K07190 | phosphorylase kinase alpha/beta subunit | 0 |
| K07191 | MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 4 | 0 |
| K07192 | flotillin | 0 |
| K07193 | SH2B adapter protein 2 | 0 |
| K07194 | Ras homolog gene family, member Q | 0 |
| K07195 | exocyst complex component 7 | 0 |
| K07196 | thyroid hormone receptor interactor 10 | 0 |
| K07197 | sterol regulatory element-binding transcription factor 1 | 0 |
| K07198 | 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31] | 0 |
| K07199 | 5'-AMP-activated protein kinase, regulatory beta subunit | 0 |
| K07200 | 5'-AMP-activated protein kinase, regulatory gamma subunit | 0 |
| K07201 | forkhead box protein O1 | 0 |
| K07202 | alpha peroxisome proliferator-activated receptor gamma coactivator 1-alpha | 0 |
| K07203 | serine/threonine-protein kinase mTOR [EC:2.7.11.1] | 0 |
| K07204 | regulatory associated protein of mTOR | 0 |
| K07205 | eukaryotic translation initiation factor 4E binding protein 1 | 0 |
| K07206 | tuberous sclerosis 1 | 0 |
| K07207 | tuberous sclerosis 2 | 0 |
| K07208 | Ras homolog enriched in brain | 0 |
| K07209 | inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10] | 0 |
| K07827 | GTPase KRas | 0 |
| K07828 | GTPase NRas | 0 |
| K08845 | A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1] | 0 |
| K11262 | acetyl-CoA carboxylase / biotin carboxylase 1 [EC:6.4.1.2 6.3.4.14 2.1.3.15] | 0 |
| K12406 | pyruvate kinase isozymes R/L [EC:2.7.1.40] | 0 |
| K12407 | glucokinase [EC:2.7.1.2] | 0 |
| K13296 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B [EC:3.1.4.17] | 0 |
| K15909 | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 [EC:3.1.3.86] | 0 |
| K16172 | insulin receptor substrate 1 | 0 |
| K17445 | insulin receptor substrate 3 | 0 |
| K17446 | insulin receptor substrate 4 | 0 |
| K17447 | SHC-transforming protein 2 | 0 |
| K17448 | SHC-transforming protein 3 | 0 |
| K17449 | SHC-transforming protein 4 | 0 |
| K17453 | protein phosphatase 1 regulatory subunit 3F | 0 |
| K18952 | atypical protein kinase C zeta type [EC:2.7.11.13] | 0 |
| K22517 | E3 ubiquitin-protein ligase CBL-B [EC:2.3.2.27] | 0 |