Help to interpret the results
The page contains two contents:
General: this table lists the KO entries and their description specific to this pathway, and provides their frequencies in Morganella morganii S4 and in the whole dataset.
Profile + homologs: the distribution of the Kegg entries of PI3K-Akt signaling pathway Kegg pathway is displayed here. Given a Kegg entry and a genome, a red box indicates that one or more loci have been annotated with, while a green box indicates that no locus/loci has(have) been annotated with it, but it/they is/are part of an Orthologous group in which other members have been annotated with that Kegg entry, so it is likely that this copy(ies) also performs this Kegg function.
Check the composition of the PI3K-Akt signaling pathway pathway
| KO | Description | #in this genome | All occurrences |
|---|---|---|---|
| K00693 | glycogen synthase [EC:2.4.1.11] | 0 | 0 |
| K00922 | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153] | 0 | 0 |
| K01084 | glucose-6-phosphatase [EC:3.1.3.9] | 0 | 0 |
| K01110 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67] | 0 | 0 |
| K01596 | phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32] | 0 | 0 |
| K02089 | cyclin-dependent kinase 4 [EC:2.7.11.22] | 0 | 0 |
| K02091 | cyclin-dependent kinase 6 [EC:2.7.11.22] | 0 | 0 |
| K02158 | Bcl-2-antagonist of cell death | 0 | 0 |
| K02161 | apoptosis regulator Bcl-2 | 0 | 0 |
| K02206 | cyclin-dependent kinase 2 [EC:2.7.11.22] | 0 | 0 |
| K02539 | myeloid leukemia cell differntiation protein MCL-1 | 0 | 0 |
| K02580 | nuclear factor NF-kappa-B p105 subunit | 0 | 0 |
| K02582 | nerve growth factor, beta | 0 | 0 |
| K02583 | tumor necrosis factor receptor superfamily member 16 | 0 | 0 |
| K02649 | phosphoinositide-3-kinase regulatory subunit alpha/beta/delta | 0 | 0 |
| K02677 | classical protein kinase C alpha type [EC:2.7.11.13] | 0 | 0 |
| K02833 | GTPase HRas | 0 | 0 |
| K02991 | small subunit ribosomal protein S6e | 0 | 0 |
| K03083 | glycogen synthase kinase 3 beta [EC:2.7.11.26] | 0 | 0 |
| K03099 | son of sevenless | 0 | 0 |
| K03176 | neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1] | 0 | 0 |
| K03258 | translation initiation factor 4B | 0 | 0 |
| K03259 | translation initiation factor 4E | 0 | 0 |
| K03456 | serine/threonine-protein phosphatase 2A regulatory subunit A | 0 | 0 |
| K03900 | von Willebrand factor | 0 | 0 |
| K03914 | coagulation factor II (thrombin) receptor | 0 | 0 |
| K04079 | molecular chaperone HtpG | 1 | 7 |
| K04129 | muscarinic acetylcholine receptor M1 | 0 | 0 |
| K04130 | muscarinic acetylcholine receptor M2 | 0 | 0 |
| K04273 | lysophosphatidic acid receptor 6 | 0 | 0 |
| K04275 | lysophosphatidic acid receptor 4 | 0 | 0 |
| K04289 | lysophosphatidic acid receptor 1 | 0 | 0 |
| K04291 | lysophosphatidic acid receptor 2 | 0 | 0 |
| K04294 | lysophosphatidic acid receptor 3 | 0 | 0 |
| K04347 | guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 | 0 | 0 |
| K04354 | serine/threonine-protein phosphatase 2A regulatory subunit B | 0 | 0 |
| K04355 | brain-derived neurotrophic factor | 0 | 0 |
| K04356 | neurotrophin 3 | 0 | 0 |
| K04357 | epidermal growth factor | 0 | 0 |
| K04358 | fibroblast growth factor | 0 | 0 |
| K04359 | platelet-derived growth factor subunit A | 0 | 0 |
| K04360 | neurotrophic tyrosine kinase receptor type 2 [EC:2.7.10.1] | 0 | 0 |
| K04361 | epidermal growth factor receptor [EC:2.7.10.1] | 0 | 0 |
| K04362 | fibroblast growth factor receptor 1 [EC:2.7.10.1] | 0 | 0 |
| K04363 | platelet-derived growth factor receptor alpha [EC:2.7.10.1] | 0 | 0 |
| K04364 | growth factor receptor-bound protein 2 | 0 | 0 |
| K04366 | RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1] | 0 | 0 |
| K04368 | mitogen-activated protein kinase kinase 1 [EC:2.7.12.2] | 0 | 0 |
| K04369 | mitogen-activated protein kinase kinase 2 [EC:2.7.12.2] | 0 | 0 |
| K04371 | mitogen-activated protein kinase 1/3 [EC:2.7.11.24] | 0 | 0 |
| K04374 | cyclic AMP-dependent transcription factor ATF-4 | 0 | 0 |
| K04377 | Myc proto-oncogene protein | 0 | 0 |
| K04382 | serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16] | 0 | 0 |
| K04389 | tumor necrosis factor ligand superfamily member 6 | 0 | 0 |
| K04392 | Ras-related C3 botulinum toxin substrate 1 | 0 | 0 |
| K04399 | caspase 9 [EC:3.4.22.62] | 0 | 0 |
| K04447 | Janus kinase 2 [EC:2.7.10.2] | 0 | 0 |
| K04450 | cyclic AMP-dependent transcription factor ATF-2 | 0 | 0 |
| K04451 | tumor protein p53 | 0 | 0 |
| K04456 | RAC serine/threonine-protein kinase [EC:2.7.11.1] | 0 | 0 |
| K04465 | nuclear receptor subfamily 4 group A member 1 | 0 | 0 |
| K04467 | inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10] | 0 | 0 |
| K04503 | G1/S-specific cyclin-D1 | 0 | 0 |
| K04526 | insulin | 0 | 0 |
| K04527 | insulin receptor [EC:2.7.10.1] | 0 | 0 |
| K04536 | guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0 | 0 |
| K04537 | guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 | 0 | 0 |
| K04538 | guanine nucleotide-binding protein subunit beta-4 | 0 | 0 |
| K04539 | guanine nucleotide-binding protein subunit beta-5 | 0 | 0 |
| K04540 | guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 | 0 | 0 |
| K04541 | guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 | 0 | 0 |
| K04542 | guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0 | 0 |
| K04543 | guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 | 0 | 0 |
| K04544 | guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 | 0 | 0 |
| K04545 | guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0 | 0 |
| K04546 | guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 | 0 | 0 |
| K04547 | guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 | 0 | 0 |
| K04548 | guanine nucleotide-binding protein G(T) subunit gamma-T1 | 0 | 0 |
| K04549 | guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 | 0 | 0 |
| K04570 | Bcl-2-like 1 (apoptosis regulator Bcl-X) | 0 | 0 |
| K04659 | thrombospondin 2/3/4/5 | 0 | 0 |
| K04688 | ribosomal protein S6 kinase beta [EC:2.7.11.1] | 0 | 0 |
| K04735 | transcription factor p65 | 0 | 0 |
| K04736 | interleukin 3 | 0 | 0 |
| K04737 | interleukin 3 receptor alpha | 0 | 0 |
| K05055 | interleukin 6 receptor | 0 | 0 |
| K05057 | oncostatin M receptor | 0 | 0 |
| K05061 | granulocyte colony-stimulating factor receptor | 0 | 0 |
| K05068 | interleukin 2 receptor alpha | 0 | 0 |
| K05069 | interleukin 2 receptor beta | 0 | 0 |
| K05070 | interleukin 2 receptor gamma | 0 | 0 |
| K05071 | interleukin 4 receptor | 0 | 0 |
| K05072 | interleukin 7 receptor | 0 | 0 |
| K05079 | erythropoietin receptor | 0 | 0 |
| K05080 | growth hormone receptor | 0 | 0 |
| K05081 | prolactin receptor | 0 | 0 |
| K05083 | receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1] | 0 | 0 |
| K05084 | receptor tyrosine-protein kinase erbB-3 [EC:2.7.10.1] | 0 | 0 |
| K05085 | receptor tyrosine-protein kinase erbB-4 [EC:2.7.10.1] | 0 | 0 |
| K05087 | insulin-like growth factor 1 receptor [EC:2.7.10.1] | 0 | 0 |
| K05089 | platelet-derived growth factor receptor beta [EC:2.7.10.1] | 0 | 0 |
| K05090 | macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1] | 0 | 0 |
| K05091 | proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1] | 0 | 0 |
| K05092 | fms-related tyrosine kinase 3 [EC:2.7.10.1] | 0 | 0 |
| K05093 | fibroblast growth factor receptor 2 [EC:2.7.10.1] | 0 | 0 |
| K05094 | fibroblast growth factor receptor 3 [EC:2.7.10.1] | 0 | 0 |
| K05095 | fibroblast growth factor receptor 4 [EC:2.7.10.1] | 0 | 0 |
| K05096 | FMS-like tyrosine kinase 1 [EC:2.7.10.1] | 0 | 0 |
| K05097 | FMS-like tyrosine kinase 4 [EC:2.7.10.1] | 0 | 0 |
| K05098 | kinase insert domain protein receptor [EC:2.7.10.1] | 0 | 0 |
| K05099 | proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1] | 0 | 0 |
| K05103 | Eph receptor A2 [EC:2.7.10.1] | 0 | 0 |
| K05121 | endothelial-specific receptor tyrosine kinase [EC:2.7.10.1] | 0 | 0 |
| K05126 | proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1] | 0 | 0 |
| K05130 | interferon receptor 1 | 0 | 0 |
| K05131 | interferon receptor 2 | 0 | 0 |
| K05405 | interleukin 6 | 0 | 0 |
| K05414 | interferon alpha | 0 | 0 |
| K05415 | interferon beta | 0 | 0 |
| K05418 | oncostatin M | 0 | 0 |
| K05423 | granulocyte colony-stimulating factor | 0 | 0 |
| K05429 | interleukin 2 | 0 | 0 |
| K05430 | interleukin 4 | 0 | 0 |
| K05431 | interleukin 7 | 0 | 0 |
| K05437 | erythropoietin | 0 | 0 |
| K05438 | growth hormone | 0 | 0 |
| K05439 | prolactin | 0 | 0 |
| K05448 | vascular endothelial growth factor A | 0 | 0 |
| K05449 | vascular endothelial growth factor C/D | 0 | 0 |
| K05450 | platelet derived growth factor C/D | 0 | 0 |
| K05451 | nerve growth factor, alpha | 0 | 0 |
| K05452 | glial cell derived neurotrophic factor | 0 | 0 |
| K05453 | macrophage colony-stimulating factor 1 | 0 | 0 |
| K05454 | fms-related tyrosine kinase 3 ligand | 0 | 0 |
| K05459 | insulin-like growth factor 1 | 0 | 0 |
| K05460 | hepatocyte growth factor | 0 | 0 |
| K05461 | KIT ligand | 0 | 0 |
| K05462 | ephrin-A | 0 | 0 |
| K05465 | angiopoietin 1 | 0 | 0 |
| K05466 | angiopoietin 2 | 0 | 0 |
| K05467 | angiopoietin 4 | 0 | 0 |
| K05629 | atrophin-1 interacting protein 1 | 0 | 0 |
| K05631 | atrophin-1 interacting protein 3 (BAI1-associated protein 1) | 0 | 0 |
| K05635 | laminin, gamma 1 | 0 | 0 |
| K05636 | laminin, beta 1 | 0 | 0 |
| K05637 | laminin, alpha 1/2 | 0 | 0 |
| K05717 | fibronectin 1 | 0 | 0 |
| K05719 | integrin beta 1 | 0 | 0 |
| K05725 | focal adhesion kinase 1 [EC:2.7.10.2] | 0 | 0 |
| K05855 | spleen tyrosine kinase [EC:2.7.10.2] | 0 | 0 |
| K05870 | cyclic AMP-responsive element-binding protein 1 | 0 | 0 |
| K06071 | serine/threonine-protein kinase N1 [EC:2.7.11.13] | 0 | 0 |
| K06236 | collagen type I alpha | 0 | 0 |
| K06237 | collagen type IV alpha | 0 | 0 |
| K06238 | collagen type VI alpha | 0 | 0 |
| K06240 | laminin, alpha 3/5 | 0 | 0 |
| K06241 | laminin, alpha 4 | 0 | 0 |
| K06243 | laminin, beta 2 | 0 | 0 |
| K06244 | laminin, beta 3 | 0 | 0 |
| K06245 | laminin, beta 4 | 0 | 0 |
| K06246 | laminin, gamma 2 | 0 | 0 |
| K06247 | laminin, gamma 3 | 0 | 0 |
| K06248 | chondroadherin | 0 | 0 |
| K06249 | reelin [EC:3.4.21.-] | 0 | 0 |
| K06250 | secreted phosphoprotein 1 | 0 | 0 |
| K06251 | vitronectin | 0 | 0 |
| K06252 | tenascin | 0 | 0 |
| K06253 | integrin binding sialoprotein | 0 | 0 |
| K06276 | 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1] | 0 | 0 |
| K06465 | B-lymphocyte antigen CD19 | 0 | 0 |
| K06476 | integrin alpha 2B | 0 | 0 |
| K06480 | integrin alpha 1 | 0 | 0 |
| K06481 | integrin alpha 2 | 0 | 0 |
| K06482 | integrin alpha 3 | 0 | 0 |
| K06483 | integrin alpha 4 | 0 | 0 |
| K06484 | integrin alpha 5 | 0 | 0 |
| K06485 | integrin alpha 6 | 0 | 0 |
| K06487 | integrin alpha V | 0 | 0 |
| K06493 | integrin beta 3 | 0 | 0 |
| K06525 | integrin beta 4 | 0 | 0 |
| K06583 | integrin alpha 7 | 0 | 0 |
| K06584 | integrin alpha 8 | 0 | 0 |
| K06585 | integrin alpha 9 | 0 | 0 |
| K06586 | integrin alpha 10 | 0 | 0 |
| K06587 | integrin alpha 11 | 0 | 0 |
| K06588 | integrin beta 5 | 0 | 0 |
| K06589 | integrin beta 6 | 0 | 0 |
| K06590 | integrin beta 7 | 0 | 0 |
| K06591 | integrin beta 8 | 0 | 0 |
| K06624 | cyclin-dependent kinase inhibitor 1B | 0 | 0 |
| K06625 | cyclin-dependent kinase inhibitor 1A | 0 | 0 |
| K06626 | G1/S-specific cyclin-E1 | 0 | 0 |
| K06630 | 14-3-3 protein epsilon | 0 | 0 |
| K06643 | E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27] | 0 | 0 |
| K06856 | immunoglobulin heavy chain | 0 | 0 |
| K07198 | 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31] | 0 | 0 |
| K07203 | serine/threonine-protein kinase mTOR [EC:2.7.11.1] | 0 | 0 |
| K07204 | regulatory associated protein of mTOR | 0 | 0 |
| K07205 | eukaryotic translation initiation factor 4E binding protein 1 | 0 | 0 |
| K07206 | tuberous sclerosis 1 | 0 | 0 |
| K07207 | tuberous sclerosis 2 | 0 | 0 |
| K07208 | Ras homolog enriched in brain | 0 | 0 |
| K07209 | inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10] | 0 | 0 |
| K07210 | inhibitor of nuclear factor kappa-B kinase subunit gamma | 0 | 0 |
| K07298 | serine/threonine-protein kinase 11 [EC:2.7.11.1] | 0 | 0 |
| K07825 | guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 | 0 | 0 |
| K07826 | guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | 0 | 0 |
| K07827 | GTPase KRas | 0 | 0 |
| K07828 | GTPase NRas | 0 | 0 |
| K08131 | collagen type IX alpha | 0 | 0 |
| K08266 | target of rapamycin complex subunit LST8 | 0 | 0 |
| K08270 | DNA-damage-inducible transcript 4 | 0 | 0 |
| K08390 | lysophosphatidic acid receptor 5 | 0 | 0 |
| K08524 | retinoid X receptor alpha | 0 | 0 |
| K08774 | transforming growth factor, alpha | 0 | 0 |
| K09047 | cyclic AMP-responsive element-binding protein 5 | 0 | 0 |
| K09048 | cyclic AMP-responsive element-binding protein 3 | 0 | 0 |
| K09049 | cyclic AMP-dependent transcription factor ATF-6 beta | 0 | 0 |
| K09408 | forkhead box protein O3 | 0 | 0 |
| K09420 | transcriptional activator Myb | 0 | 0 |
| K09487 | heat shock protein 90kDa beta | 0 | 0 |
| K09554 | cell division cycle protein 37 | 0 | 0 |
| K09782 | amphiregulin | 0 | 0 |
| K09784 | epiregulin | 0 | 0 |
| K10151 | G1/S-specific cyclin-D2 | 0 | 0 |
| K10152 | G1/S-specific cyclin-D3 | 0 | 0 |
| K10159 | toll-like receptor 2 | 0 | 0 |
| K10160 | toll-like receptor 4 | 0 | 0 |
| K10167 | T-cell leukemia/lymphoma 1A | 0 | 0 |
| K10605 | breast cancer type 1 susceptibility protein [EC:2.3.2.27] | 0 | 0 |
| K11217 | Janus kinase 1 [EC:2.7.10.2] | 0 | 0 |
| K11218 | Janus kinase 3 [EC:2.7.10.2] | 0 | 0 |
| K11583 | serine/threonine-protein phosphatase 2A regulatory subunit B'' | 0 | 0 |
| K11584 | serine/threonine-protein phosphatase 2A regulatory subunit B' | 0 | 0 |
| K12230 | phosphoinositide 3-kinase adapter protein 1 | 0 | 0 |
| K12457 | neurotrophin 4 | 0 | 0 |
| K13242 | nitric-oxide synthase, endothelial [EC:1.14.13.39] | 0 | 0 |
| K13302 | serum/glucocorticoid-regulated kinase 1 [EC:2.7.11.1] | 0 | 0 |
| K13303 | serum/glucocorticoid-regulated kinase 2 [EC:2.7.11.1] | 0 | 0 |
| K13304 | serum/glucocorticoid-regulated kinase 3 [EC:2.7.11.1] | 0 | 0 |
| K13769 | insulin-like growth factor 2 | 0 | 0 |
| K16172 | insulin receptor substrate 1 | 0 | 0 |
| K16197 | 14-3-3 protein beta/theta/zeta | 0 | 0 |
| K16198 | 14-3-3 protein gamma/eta | 0 | 0 |
| K16332 | retinoblastoma-like protein 2 | 0 | 0 |
| K16333 | CREB-regulated transcription coactivator 2 | 0 | 0 |
| K16339 | acyl-coenzyme A thioesterase THEM4 [EC:3.1.2.2] | 0 | 0 |
| K16340 | PH domain and leucine-rich repeat-containing protein phosphatase [EC:3.1.3.16] | 0 | 0 |
| K16341 | Bcl-2-like protein 11 | 0 | 0 |
| K16836 | T-cell leukemia/lymphoma 1B | 0 | 0 |
| K16837 | mature T-cell proliferation-1 type B1 | 0 | 0 |
| K16857 | thrombospondin 1 | 0 | 0 |
| K16858 | vascular endothelial growth factor B | 0 | 0 |
| K16859 | placenta growth factor | 0 | 0 |
| K17386 | platelet-derived growth factor subunit B | 0 | 0 |
| K18496 | fibroblast growth factor 1 | 0 | 0 |
| K18497 | fibroblast growth factor 2 | 0 | 0 |
| K19719 | collagen type II alpha | 0 | 0 |
| K21289 | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [EC:2.7.1.153] | 0 | 0 |
| K21290 | phosphoinositide-3-kinase regulatory subunit 5/6 | 0 | 0 |
| K22428 | fibroblast growth factor 23 | 0 | 0 |
| K22429 | fibroblast growth factor 21 | 0 | 0 |
| K22603 | fibroblast growth factor 19 | 0 | 0 |
| K23691 | serine/threonine-protein kinase N2 [EC:2.7.11.13] | 0 | 0 |
| K23692 | serine/threonine-protein kinase N3 [EC:2.7.11.13] | 0 | 0 |
| K25414 | neurturin | 0 | 0 |
| K25415 | artemin | 0 | 0 |
| K25416 | persephin | 0 | 0 |